DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and lgc-39

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_504821.3	Gene:	lgc-39 / 184265	WormBaseID:	WBGene00017314	Length:	563	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	137/480 - (28%)
Similarity:	231/480 - (48%)	Gaps:	48/480 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LCS--ASLANNAKINFREKEKKVLDQILGAG----KYDARIRPSGING--TDGPAVVRVNIFVRS 72
            ||.  .|.....::.:.|...::| :::|.|    .|:..:.|....|  ||    |.|.:::.|
Worm    99 LCEPHKSGGQTGELKWSESGDRLL-KVIGNGVVEDGYNMFMAPGQSQGKRTD----VHVAVYIES 158

  Fly    73 ISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNII 137
            :|.....:|::.|.:.....|.|.||..:.....|....|. |:|:|.|||:|.|.|..:...:.
Worm   159 MSSFKAQSMDFEVDMYLAMGWFDRRLAHNCTHPILVTSKLI-ADRIWYPDLYFVNSKYAYLQEVT 222

  Fly   138 MPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQ 202
            .||:.:.::|:|.:..::|:.:||:|.|:|||:|||.|.|.|.:.|:.:....:...|::..|..
Worm   223 TPNLMVIVYPDGLIFKTMRLDVTLSCMMDLKLFPLDYQECPLTIQSFAYIEQIVNLTWRDDPPNF 287

  Fly   203 VVK-----NLHLPRFTLEKFLTDYCNSKTNTGE--YSCLKVDLLFKREFSYYLIQIYIPCCMLVI 260
            .:.     .|:..:.|.::|:..........||  :||::..::.||...:::||.|||..|||.
Worm   288 PIGFNPDIKLNDMQITNKRFVKCAGPYPMFRGEAAWSCIQGYIVMKRLVLFHIIQTYIPTGMLVS 352

  Fly   261 VSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEF 325
            :||:|||||..|.|||:||.:|:|||:.|.::|....||.|||.||:|:|.......:|..|||:
Worm   353 ISWMSFWLDPRASPARISLTITSLLTLTTMSNGARQDLPQVSYIKALDIWLTFSQALIFLVLLEY 417

  Fly   326 ALVNY----ASRSGSNKANMHKENMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGGQQ 386
            :.|:|    .:...|::...::|.:::.:|: |:|.....::.....:|.|  ..|...|....|
Worm   418 SFVSYYMTKRTTDCSHRNMFYEERVQECKRE-EKARKSIVNNNKPVIANNT--EGSDLNRNKKSQ 479

  Fly   387 KPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSK-------------RIDVISRI 438
            :..:.| |....|.:..........|.|      ..:||.|...             :||..||.
Worm   480 QFSLTH-GISACLNESSALMSVTPVPSR------LFTKFDTNKPCARCSEKNERIAFKIDEYSRW 537

  Fly   439 TFPLVFALFNLVYWSTYLFREEEDE 463
            .||.||:||.:.||..:.:|....|
Worm   538 LFPTVFSLFCVSYWLYFTWRSSASE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	135/470 (29%)
lgc-39	NP_504821.3	LIC	119..554	CDD:273305	131/450 (29%)
		Neur_chan_LBD	132..336	CDD:280998	56/208 (27%)
		Neur_chan_memb	343..551	CDD:280999	68/217 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020