Protein Alignment GluClalpha and lgc-44

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_505954.2
• Gene: lgc-44 / 179600
• WormBaseID: WBGene00009790
• Length: 618
• Species: Caenorhabditis elegans
• Alignment Length: 442
• Identity: 121/442 - (27%)
• Similarity: 186/442 - (42%)
• Gaps: 90/442 - (20%)

  Fly    35 KVLDQILGAG---------------------KYDARIRPSGINGTDGPAVVRVNIFVRSISKIDD 78
            |.||||:...                     :||||..||  ...|....|:|.|.|:|:|..:.
 Worm   227 KPLDQIMNQNLGLDYQRPLPSSTILPFLRKMEYDARQPPS--LHVDDTVTVKVGIAVQSMSNFEL 289

  Fly    79 VTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYI 143
            .||:|.:....|..|.|.||: .|:...:.....|....:|.||..|:|.|...||.:...|.|:
 Worm   290 STMDYDLDAWVRMSWIDPRLR-HDLSRPILVNDYTFLKMIWRPDPIFTNSKYSTFHKVTYLNFYL 353

  Fly   144 RIFPNGSVLYSIRISL-TLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLW--KEGDPVQVVK 205
            .|||:|.:...:|:.| ..|..:.|..||.|....||:::|.|:|.:.:...|  ...|.:.:.|
 Worm   354 FIFPDGKIFMDMRVYLKPTAAQIVLCKYPHDNPAVSLKISSMGFTQDVVKLEWFSDTNDAIWIEK 418

  Fly   206 NLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQ 270
            |:.:|..::.....|.||....:|.||||:......||..|::...|||..:.|:.||:|.||.:
 Worm   419 NVKIPELSIRHLHPDTCNGVRKSGVYSCLEAKFYMHREVGYHIANTYIPTAICVVFSWISVWLPE 483

  Fly   271 GAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSG 335
            ..|..|:.:.:|..||::.:.:.....||.|||.||||:|.|...||||..:|: |||..:....
 Worm   484 EFVEGRIFVSLTVFLTLSAENNSAKEELPKVSYVKAIDIWFGFTSTFVFLTMLQ-ALVVISLEHN 547

  Fly   336 SNKANMHKENMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALE 400
            |.:..:..||           :||..|....|.|
 Worm   548 SKRLRLKFEN-----------NLDGYSKYQMTKS------------------------------- 570

  Fly   401 KRLQCEVHMQAPKRPNCCKTWLSKFPTR-SKRIDVISRITFPLVFALFNLVY 451
                               ..||::..| :::||...::.:|::|.||.:.|
 Worm   571 -------------------MLLSRYYHRMARQIDTFCKVMYPVIFLLFLMFY 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	121/442 (27%)
lgc-44	NP_505954.2	LGIC_ECD_anion	273..456	CDD:349788	55/183 (30%)
		Cys-loop	374..388	CDD:349788	4/13 (31%)
		LGIC_TM_anion	459..603	CDD:349851	51/205 (25%)
		TM1 helix	459..482	CDD:349851	9/22 (41%)
		TM2 helix	486..510	CDD:349851	5/23 (22%)
		TM3 helix	518..579	CDD:349851	24/122 (20%)
		TM4 helix	580..603	CDD:349851	6/22 (27%)