DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Glra1

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001277750.1	Gene:	Glra1 / 14654	MGIID:	95747	Length:	457	Species:	Mus musculus

Alignment Length:	469	Identity:	200/469 - (42%)
Similarity:	269/469 - (57%)	Gaps:	37/469 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YFWAILYFASLCSASLANNAKINFREKEKKV-----LDQILG-AGKYDARIRPSGINGTDGPAV- 63
            |.|..:.|.||.::..|..|    |...|.:     ||:::| ...|||||||:    ..||.|
Mouse    10 YLWETIVFFSLAASKEAEAA----RSAPKPMSPSDFLDKLMGRTSGYDARIRPN----FKGPPVN 66

  Fly    64 VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNE 128
            |..|||:.|...|.:.||:|.|.:..|:||.|.||.:::.......|..:..:.:|.|||||:||
Mouse    67 VSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANE 131

  Fly   129 KEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVF 193
            |..|||.|...|..:||..||:|||||||:|||||||:||.:|:|.|.|.:::.|:|:|.|||:|
Mouse   132 KGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIF 196

  Fly   194 LWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCC 256
            .|:|...|||...|.||:|.|  ||.|. ||....|||:::|::.....:|:..|||||:|||..
Mouse   197 EWQEQGAVQVADGLTLPQFILKEEKDLR-YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSL 260

  Fly   257 MLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGA 321
            ::||:||:|||::..|.||||.||:||:|||.||:||..||||.|||.||||:|..|||.|||.|
Mouse   261 LIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSA 325

  Fly   322 LLEFALVNYASRSGSNKANMHKE--NMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGG 384
            |||:|.||:.||       .|||  ..::|||..:...|:...|  |......|..:   |.|.|
Mouse   326 LLEYAAVNFVSR-------QHKELLRFRRKRRHHKSPMLNLFQD--DEGGEGRFNFS---AYGMG 378

  Fly   385 QQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSK-FPTRSKRIDVISRITFPLVFALFN 448
               |......|.::: |..........|..|:.....:.| |..|:|:||.||||.||:.|.:||
Mouse   379 ---PACLQAKDGISV-KGANNNNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFN 439

  Fly   449 LVYWSTYLFREEED 462
            :.||..|.....||
Mouse   440 MFYWIIYKIVRRED 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	197/460 (43%)
Glra1	NP_001277750.1	LIC	7..446	CDD:273305	197/460 (43%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	230..235		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20083
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2310
Isobase	1	0.950	-	0	Normalized mean entropy	S3705
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm44180
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4995
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.960