Protein Alignment GluClalpha and Gabrg3

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: XP_017177467.1
• Gene: Gabrg3 / 14407
• MGIID: 95624
• Length: 468
• Species: Mus musculus
• Alignment Length: 482
• Identity: 143/482 - (29%)
• Similarity: 220/482 - (45%)
• Gaps: 124/482 - (25%)

  Fly    36 VLDQILGAGKYDARIRPS-GINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            :|:::|  .:||.::||. ||.    |.|:.|:|:|.||..:..:.|||.:.:.|.:.|||.||:
Mouse    50 ILNKLL--REYDKKLRPDIGIK----PTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLR 108

  Fly   100 FDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLA 162
            |:   ..:|.|||..  ...:|:||..|.|.|....|.|..||..:||:.:|.:||::|:::...
Mouse   109 FN---STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

  Fly   163 CPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVV--KNLHLPRFTLEKFLTDYCNSK 225
            |.:.|..:|:|...|.|..:|||:...::::.|:: :.|:..  |:..|.:|       |:...:
Mouse   171 CQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRK-NSVEAADQKSWRLYQF-------DFMGLR 227

  Fly   226 -------TNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTT 283
                   |:.|:|..:.:.....|...|:.||.||||.:.|::||||||:.:.|.|||.:||:||
Mouse   228 NTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITT 292

  Fly   284 LLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKK 348
            :|||.|.::....|||.|||..|:|::..||..|||.||:|:|.:||.|       :..|..::|
Mouse   293 VLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS-------SCRKPTIRK 350

  Fly   349 KRRDLEQASLDAASDLLDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPK 413
            |:          .|.||..||.                              :.:...:.:|||.
Mouse   351 KK----------TSQLLHPDST------------------------------RWIPDRISLQAPS 375

  Fly   414 -------RPN----------------------------------CCKTWLSKFPTRSKRI----- 432
                   ||.                                  ||.........|..||
Mouse   376 NYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVS 440

  Fly   433 --DVISRITFPLVFALFNLVYWSTYLF 457
              |..||:.||..|.|||||||..||:
Mouse   441 ELDSYSRVFFPTSFLLFNLVYWVGYLY 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	141/478 (29%)
Gabrg3	XP_017177467.1	LIC	50..465	CDD:455710	141/478 (29%)
		LGIC_ECD_GABAAR_G	71..252	CDD:349801	54/191 (28%)
		Cys-loop	171..185	CDD:349801	4/13 (31%)