Protein Alignment GluClalpha and Gabrd

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_001408102.1
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Alignment Length: 506
• Identity: 155/506 - (30%)
• Similarity: 237/506 - (46%)
• Gaps: 88/506 - (17%)

  Fly     8 WAILYFASLCS-----------ASLANNAKINFREKEKKVLDQILGAGK---------------- 45
            |.:|....||:           |.|:..|         :||..:|||.:
Mouse     6 WLLLPLLLLCTQPHHGARSKDPADLSPAA---------RVLSAVLGAERCAVGRDWSRQARAMND 61

  Fly    46 -----------------------YDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQL 87
                                   |....|| ||.|  .|..|.:.:.|.||..|.:..|||::.:
Mouse    62 IGDYVGSNLEISWLPNLDGLMEGYARNFRP-GIGG--APVNVALALEVASIDHISEANMEYTMTV 123

  Fly    88 TFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVL 152
            ...:.|.|.||.::.....|. |.....:::|:||.|..|.|...||::.:.|..||:.|:|.:|
Mouse   124 FLHQSWRDSRLSYNHTNETLG-LDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVIL 187

  Fly   153 YSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEG-DPVQVVKNLHLPRFTLE- 215
            |||||:.|:||.|:|..||||.|.|.|.:.|||:::.|:|:.|.|. :.:..:..|.|.:||:.
Mouse   188 YSIRITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITS 252

  Fly   216 -KFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSL 279
             :|.|:..|.| :.|::..|.:....:|....|:||.|:|..:||.:||||||:.|.||||||||
Mouse   253 YRFTTELMNFK-SAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSL 316

  Fly   280 GVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKE 344
            |:||:|||.|......:|||..|..||:||:..:|..|||.||:|:|..::            ..
Mouse   317 GITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF------------NA 369

  Fly   345 NMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGGQQKPLVRH----PGDPLALEKRLQC 405
            :.:|||:    |.:.......:.|......:.|..|.|..|:..:.|.    ||:.:...:.::.
Mouse   370 DYRKKRK----AKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEV 430

  Fly   406 EVHMQAPKRPNCCKTWLSKF-PTRSKRIDVISRITFPLVFALFNLVYWSTY 455
            |...:...||.......|:. |..:..||:.:|..||..||..|::||:.|
Mouse   431 EAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	154/504 (31%)
Gabrd	NP_001408102.1	LGIC_ECD	97..280	CDD:475126	63/184 (34%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	45/99 (45%)
		TM1 helix	283..306	CDD:349857	13/22 (59%)
		TM2 helix	310..334	CDD:349857	14/23 (61%)
		TM3 helix	342..368	CDD:349857	12/37 (32%)