Protein Alignment GluClalpha and Gabra4

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_001345970.1
• Gene: Gabra4 / 14397
• MGIID: 95616
• Length: 578
• Species: Mus musculus
• Alignment Length: 576
• Identity: 175/576 - (30%)
• Similarity: 256/576 - (44%)
• Gaps: 140/576 - (24%)

  Fly     9 AILYFASLCSASLANNAKINFREKEK-------KVLDQILGAGKYDARIRPSGINGTD------- 59
            |:|:|  ||.|:..|.:.....:.||       ::||.:|..  ||.|:|| |..|||
Mouse    19 ALLHF--LCLAACLNESPGQNSKDEKLCPENFTRILDSLLDG--YDNRLRP-GFGGTDCFKTCKC 78

  Fly    60 ----------------GPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRL 107
                            ||.. |:.:|:|.|...:.||.|||::.:.||:.|.|:|||:|   |.:
Mouse    79 ALSVRLWSACLFVEILGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD---GPI 140

  Fly   108 KYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLY 170
            :.|.|..  ..:||.||.||.|.|:...||:..||...||..||::||::|::::..|||.|..:
Mouse   141 EILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDF 205

  Fly   171 PLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEKFLTDYCNS-------KTNT 228
            |:|...|.|:..||.:..:::::.|.:|..    |::.:|:.:......|....       |:.|
Mouse   206 PMDGHACPLKFGSYAYPKSEMIYTWTKGPE----KSVEVPKESSSLVQYDLIGQTVSSETIKSIT 266

  Fly   229 GEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSG 293
            |||..:.|....:|:..|::||.||||.|.||:|.||||:::.:||||...|:||:|||.|.:..
Mouse   267 GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSIS 331

  Fly   294 INASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKA------------------- 339
            ...|||.|||..|:|.:..||..|||.||:|||.|||.:.....||
Mouse   332 ARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKE 396

  Fly   340 --------NMHKE-NMKKKRRDLEQASLDAAS-----------DLLDTDSNAT-----------F 373
                    |.|.. ||:|:...|..:..|..|           ..:...|.||           |
Mouse   397 KHTETSLQNTHANLNMRKRTNALVHSESDVKSRTEVGNHSSKTSAVQESSEATPKAHLASSPNPF 461

  Fly   374 AMA------SQFARG-GGQQKPLVRHPGDPLALEK------------RLQCEVHMQA-------- 411
            :.|      |..||| .....|.......|.:|..            |::..|:...
Mouse   462 SRANAAETMSAAARGLSSAASPSPHGTLRPASLGSASTRPAFGSRLGRIKTTVNTTGAAGNVSAT 526

  Fly   412 --PKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFRE--EEDE 463
              |..|....:..||       ||..:||.||:.|..||:|||..||.::  |:.|
Mouse   527 PPPPAPPPSGSGTSK-------IDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSE 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	171/564 (30%)
Gabra4	NP_001345970.1	LIC	13..565	CDD:455710	171/564 (30%)
		LGIC_ECD_GABAAR_A4	57..281	CDD:349838	71/233 (30%)
		Cys-loop	198..212	CDD:349838	6/13 (46%)