Protein Alignment GluClalpha and CHRNB3

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 77/327 - (23%)
• Similarity: 143/327 - (43%)
• Gaps: 48/327 - (14%)

  Fly    31 EKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLT---FREQ 92
            |.|..:|..:...  |...:||. ::..|   .::| .|...||::.||..:..:..|   .:::
Human    27 ENEDALLRHLFQG--YQKWVRPV-LHSND---TIKV-YFGLKISQLVDVDEKNQLMTTNVWLKQE 84

  Fly    93 WTDERLKF--DDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSI 155
            |||.:|::  ||..|.......:|:  :|:||:......:|.|...:|..|.::  .||:|:::.
Human    85 WTDHKLRWNPDDYGGIHSIKVPSES--LWLPDIVLFENADGRFEGSLMTKVIVK--SNGTVVWTP 145

  Fly   156 RISLTLACPMNLKLYPLDRQICSLRMAS--YGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEKFL 218
            ..|...:|.|::..:|.|||.||::..|  |..|..||:.:.:..|......|..
Human   146 PASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGE---------- 200

  Fly   219 TDYCNSKTNTG-------EYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWL--DQGAVP 274
            .:..|:|...|       .|..:....:.:|...:|.:.:.|||..|..::.:.|:|  |:|
Human   201 WEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG--- 262

  Fly   275 ARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFV-----FGALLEFALVNYASRS 334
            .::||..:.|:::......|...:|  |.:|.|.: .|..|.|:     ...::...::|...||
Human   263 EKLSLSTSVLVSLTVFLLVIEEIIP--SSSKVIPL-IGEYLLFIMIFVTLSIIVTVFVINVHHRS 324

  Fly   335 GS 336
            .|
Human   325 SS 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	77/327 (24%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	77/327 (24%)