Protein Alignment GluClalpha and Gabra5

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_795916.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 440
• Identity: 158/440 - (35%)
• Similarity: 236/440 - (53%)
• Gaps: 52/440 - (11%)

  Fly    35 KVLDQILGAGKYDARIRPSGINGTDGPAV--VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDER 97
            ::||.:|..  ||.|:|| |:    |..:  ||.:|:|.|...:.|..|||::.:.||:.|.|||
Mouse    51 RILDGLLDG--YDNRLRP-GL----GERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDER 108

  Fly    98 LKFDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLT 160
            |:|   :|.::.|.|..  |:::|.||.||.|.|:...||:..||..:|:..:|::||::|::::
Mouse   109 LRF---KGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTIS 170

  Fly   161 LACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVV--------KNLHLPRFTLEKF 217
            ..|||.|:.:|:|...|.|:..||.:..:::|::|..|....||        ...||...|:.
Mouse   171 AECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVG-- 233

  Fly   218 LTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVT 282
             |:  |..|:||||:.:......||:..|::||.|:||.|.||:|.|||||::.:||||...|||
Mouse   234 -TE--NISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVT 295

  Fly   283 TLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSG---SNKANMHKE 344
            |:|||.|.:.....|||.|:|..|:|.:..||..|||.||:|||.|||.::.|   ..|..:...
Mouse   296 TVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA 360

  Fly   345 NMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHM 409
            .:|||.|:|          :|:..:||       |..|.....|.:.....|..........:..
Mouse   361 KIKKKEREL----------ILNKSTNA-------FTTGKLTHPPNIPKEQPPAGTANAPTVSIKA 408

  Fly   410 QAPKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFRE 459
            ...|.....||:.|     ..:||.:|||.||::|..||||||:|||.||
Mouse   409 SEEKTAESKKTYNS-----ISKIDKMSRIVFPILFGTFNLVYWATYLNRE 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	153/434 (35%)
Gabra5	NP_795916.1	LIC	15..449	CDD:455710	153/434 (35%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	70/212 (33%)
		Cys-loop	173..187	CDD:349839	6/13 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		2/20 (10%)