DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naam and pnc1

DIOPT Version :9

Sequence 1:	NP_001262738.1	Gene:	Naam / 42348	FlyBaseID:	FBgn0051216	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_596029.2	Gene:	pnc1 / 2540906	PomBaseID:	SPBC365.20c	Length:	220	Species:	Schizosaccharomyces pombe

Alignment Length:	232	Identity:	71/232 - (30%)
Similarity:	112/232 - (48%)	Gaps:	27/232 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 AFLIVDVQNDFISGSLDISNCSAQQQGHEILEPINKLLDT-VDFDAVFYSLDWHPSDHVSFIDNV 161
            |.:||||||||:....    .|:.:...|::..||:||:. ..:|.|..:.|.||.||:||..:.
pombe     6 ALIIVDVQNDFVHPVY----ISSGESALEVVPVINRLLENDYKWDTVIATKDVHPKDHLSFTTSH 66

  Fly   162 KMRPMDESSALDSDS-AKVFDTVIFAGPPPMKQRLWPRHCVQDSWGAELHKDLKVVDHGIKVYKG 225
            ...|....:.::.:: ..|:           ||.||..|||:::.|.|....|........:.||
pombe    67 SSTPKPSGTVVNIEAYGHVY-----------KQTLWNSHCVENTPGCEFPDSLNGDRIEFVIPKG 120

  Fly   226 TNPEVDSYSVFWDNKKLSDTTLNAQLKMKGATDIYVCGLAYDVCVGATAVDALSAGYRTILIDDC 290
            ::..|:|||.|:|... .|..|.|.|..||.||:::.|:|.|:||..||:.| ...|.|.:|.:.
pombe   121 SDRLVESYSGFYDAIG-RDNGLKAILDKKGITDVFIAGVATDICVKETALHA-RHWYNTYIISEA 183

  Fly   291 CRG--TDVH-----DIEHTK-EKVNTSDGVIVHTNQV 319
            .:|  |:.|     |....| |.::..|.::....:|
pombe   184 VKGSSTESHNQAIKDFRDAKIEVISEKDPILQSVRKV 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naam	NP_001262738.1	EFh	20..81	CDD:238008
		EF-hand_7	21..82	CDD:290234
		nicotinamidase	97..315	CDD:238493	70/226 (31%)
pnc1	NP_596029.2	cysteine_hydrolases	6..207	CDD:294151	69/217 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	90	1.000	Domainoid score	I2067
eggNOG	1	0.900	-	-		E1_COG1335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5938
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1749
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007602
OrthoInspector	1	1.000	-	-		oto101911
orthoMCL	1	0.900	-	-		OOG6_100439
Panther	1	1.100	-	-	LDO	PTHR11080
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16483
SonicParanoid	1	1.000	-	-		X6476
TreeFam	0	0.000	Not matched by this tool.
	11	10.890