Protein Alignment CG7432 and KLKB1

DIOPT Version :10

• Sequence 1: NP_650825.2
• Gene: CG7432 / 42347
• FlyBaseID: FBgn0038727
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_011530232.1
• Gene: KLKB1 / 3818
• HGNCID: 6371
• Length: 649
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 131/517 - (25%)
• Similarity: 203/517 - (39%)
• Gaps: 146/517 - (28%)

  Fly   296 TPRTTTTSTTTEAPITLTPLDQLAEASDEAGTGKDVENYCKTPSGRRGRCEDLSSCPALLLNLSS 360
            ||......:..|:..:|.|.     |..|.|.       |:|.|        |..|...:    :
Human   175 TPTAIKVLSNVESGFSLKPC-----ALSEIGN-------CRTTS--------LCDCGCHM----N 215

  Fly   361 LRESLCFKSLYVPGVCCPISSSSTVLTTQKPLRL------------TTRPTTTTSTTKATQPTKK 413
            :.:.|.|..:.|..|..|.:.....:.|..|..|            :.|......|:::..|
Human   216 IFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTP--- 277

  Fly   414 STVRPTTRPTSGLVLIPQKKPPTTTTTTTTEVPLEPE-------GLDEI------GNNIVD---- 461
            |:..|.....||..|:..|:        |...|...:       |.:|:      |.|:..
Human   278 SSSTPQENTISGYSLLTCKR--------TLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCT 334

  Fly   462 -------------PDEC-------------------------GQQEYS-----TG---------- 473
                         |::|                         |...||     ||
Human   335 KMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTS 399

  Fly   474 -RIVGGVEAPNGQWPWMAAIFLHGPKRT--EFWCGGSLIGTKYILTAAHCTRDSRQKPFAARQFT 535
             |||||..:..|:|||..::.:   |.|  ...|||||||.:::||||||. |........|.::
Human   400 TRIVGGTNSSWGEWPWQVSLQV---KLTAQRHLCGGSLIGHQWVLTAAHCF-DGLPLQDVWRIYS 460

  Fly   536 VRLGDIDLSTDAEPSDPVTFAVKEVRTHERFSRIGFYNDIAILVLDKPVRKSKYVIPVCLPKGIR 600
            ..|...|::.|...|.     :||:..|:.:......:|||::.|..|:..:::..|:|||.
Human   461 GILNLSDITKDTPFSQ-----IKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPS--- 517

  Fly   601 MPPKERLPGRRAT------VVGWGTTYYGGKESTSQRQAELPIWRNEDCDRSYFQ-PINENFICA 658
                   .|..:|      |.|||.:...|:.....::..:|:..||:|.:.|.. .|.:..:||
Human   518 -------KGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCA 575

  Fly   659 GYSDGGVDACQGDSGGPLMMRYDSHWVQLGVVSFGNKCGEPGYPGVYTRVTEYLDWIRDHTR 720
            ||.:||.|||:|||||||:.:::..|..:|:.|:|..|.....|||||:|.||:|||.:.|:
Human   576 GYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQ 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7432	NP_650825.2	CLIP	335..378	CDD:197829	9/42 (21%)
		Tryp_SPc	475..718	CDD:238113	86/251 (34%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519	4/18 (22%)
		APPLE	212..295	CDD:128519	16/89 (18%)
		APPLE	303..386	CDD:128519	9/82 (11%)
		Tryp_SPc	402..632	CDD:238113	84/248 (34%)