DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7432 and Plat

DIOPT Version :9

Sequence 1:	NP_650825.2	Gene:	CG7432 / 42347	FlyBaseID:	FBgn0038727	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_037283.2	Gene:	Plat / 25692	RGDID:	3342	Length:	559	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	116/444 - (26%)
Similarity:	176/444 - (39%)	Gaps:	129/444 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 GKDVENYCKTPSGRRGRCEDLSSCPALLLNLSSLRESLCFKSLYVPGVCCPISSSSTVLTTQKPL 392
            ||....:|.||:..:|..||                             |.:...
  Rat   193 GKYTTEFCSTPACPKGPTED-----------------------------CYVGKG---------- 218

  Fly   393 RLTTRPTTTTSTTKATQPTKKSTVRPTTRPTSGLVLIPQKKPPTTTTTTTTEVPLEPEGLDEIGN 457
             :|.|.|.:.:|:||           :..|.:.::||.:       |.|......:..||.. .|
  Rat   219 -VTYRGTHSFTTSKA-----------SCLPWNSMILIGK-------TYTAWRANSQALGLGR-HN 263

  Fly   458 NIVDPD--------------------------ECGQQEYSTG--RIVGGVEAPNGQWPWMAAIFL 494
            ...:||                          .||.::|...  ||.||:.......||.||||:
  Rat   264 YCRNPDGDAKPWCHVMKDRKLTWEYCDMSPCSTCGLRQYKQPQFRIKGGLFTDITSHPWQAAIFV 328

  Fly   495 HGPKRT---EFWCGGSLIGTKYILTAAHCTRDSRQKPFAARQFTVRLGDIDLSTDAEPSDPVTFA 556
            .. ||:   .|.|||.||.:.::|:||||..:.    |......|.||........|  :..||.
  Rat   329 KN-KRSPGERFLCGGVLISSCWVLSAAHCFVER----FPPHHLKVVLGRTYRVVPGE--EEQTFE 386

  Fly   557 VKEVRTHERFSRIGFYNDIAILVL----DKPVRKSKYVIPVCLPKGIRMPPKERLPGRRATVVGW 617
            :::...|:.|....:.||||:|.|    .:..::|..|...|||     .|..:||       .|
  Rat   387 IEKYIVHKEFDDDTYDNDIALLQLRSDSSQCAQESSSVGTACLP-----DPDVQLP-------DW 439

  Fly   618 ---GTTYYGGKESTSQ------RQAELPIWRNEDCDRSYF--QPINENFICAGYSDGG-----VD 666
               ..:.||..|::|.      ::|.:.::.:..|...:.  :.|..|.:|||.:..|     .|
  Rat   440 TECELSGYGKHEASSPFFSDRLKEAHVRLYPSSRCTSQHLFNKTITSNMLCAGDTRTGGNQDVHD 504

  Fly   667 ACQGDSGGPLMMRYDSHWVQLGVVSFGNKCGEPGYPGVYTRVTEYLDWIRDHTR 720
            ||||||||||:...|.....||::|:|..||:...||:||:||.||:||:|:.:
  Rat   505 ACQGDSGGPLVCMIDKRMTLLGIISWGLGCGQKDVPGIYTKVTNYLNWIQDNMK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7432	NP_650825.2	CLIP	335..378	CDD:197829	6/42 (14%)
		Tryp_SPc	474..715	CDD:214473	85/263 (32%)
		Tryp_SPc	475..718	CDD:238113	86/265 (32%)
Plat	NP_037283.2	Important for binding to annexin A2. /evidence=ECO:0000250	39..49
		Kringle	124..205	CDD:395005	5/11 (45%)
		KR	210..295	CDD:238056	19/143 (13%)
		Tryp_SPc	311..556	CDD:238113	85/263 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4384
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050