DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7432 and F2

DIOPT Version :9

Sequence 1:	NP_650825.2	Gene:	CG7432 / 42347	FlyBaseID:	FBgn0038727	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	492	Identity:	136/492 - (27%)
Similarity:	191/492 - (38%)	Gaps:	113/492 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 VPVAQGAQQSQQKIKIPTTPRTTTTSTTTEAP-----------------ITLTPLDQLAEASDEA 325
            :||.     .|.::.:..|||:..:|.....|                 :|...|..||.||.:|
Human   183 IPVC-----GQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQA 242

  Fly   326 ---GTGKD-------VENYCKTPSGRR--------GRCEDLSSCPALLLNLSSLRESLCFKSLYV 372
               ...:|       |||:|:.|.|..        |:..|...|     :|:...|::
Human   243 KALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYC-----DLNYCEEAV------- 295

  Fly   373 PGVCCPISSSSTVLTTQKPLRLTTRPTTTTSTTKATQPTKKSTVRPTT----RPTSGLVLIPQKK 433
                  ...:...|.......:..|..|:...|         ...|.|    ....||..:.:||
Human   296 ------EEETGDGLDEDSDRAIEGRTATSEYQT---------FFNPRTFGSGEADCGLRPLFEKK 345

  Fly   434 PPTTTTTTTTEVPLEPEGLDEIGNNIVDPDECGQQEYSTGRIVGGVEAPNGQWPWMAAIFLHGPK 498
                    :.|...|.|.|               :.|..||||.|.:|..|..||...:|...|:
Human   346 --------SLEDKTERELL---------------ESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQ 387

  Fly   499 RTEFWCGGSLIGTKYILTAAHC-TRDSRQKPFAARQFTVRLGDIDLSTDAEPSDPVTFAVKEVRT 562
              |..||.|||..:::|||||| ......|.|......||:|....:......:.::. ::::..
Human   388 --ELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM-LEKIYI 449

  Fly   563 HERFS-RIGFYNDIAILVLDKPVRKSKYVIPVCLPKGIRMPPKERL-PGRRATVVGWGT-----T 620
            |.|:: |.....|||::.|.|||..|.|:.|||||.  |......| .|.:..|.|||.     |
Human   450 HPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPD--RETAASLLQAGYKGRVTGWGNLKETWT 512

  Fly   621 YYGGKESTSQRQ-AELPIWRNEDCDRSYFQPINENFICAGYS-DGGV--DACQGDSGGPLMMR-- 679
            ...||...|..| ..|||.....|..|....|.:|..||||. |.|.  |||:||||||.:|:
Human   513 ANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSP 577

  Fly   680 YDSHWVQLGVVSFGNKCGEPGYPGVYTRVTEYLDWIR 716
            :::.|.|:|:||:|..|...|..|.||.|.....||:
Human   578 FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7432	NP_650825.2	CLIP	335..378	CDD:197829	8/50 (16%)
		Tryp_SPc	474..715	CDD:214473	91/254 (36%)
		Tryp_SPc	475..718	CDD:238113	92/256 (36%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056	1/2 (50%)
		KR	211..293	CDD:214527	18/86 (21%)
		Thrombin_light	317..363	CDD:286482	13/77 (17%)
		Tryp_SPc	363..613	CDD:214473	91/254 (36%)
		Tryp_SPc	364..616	CDD:238113	92/256 (36%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		14/21 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4483
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960