DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7432 and Plg

DIOPT Version :9

Sequence 1:	NP_650825.2	Gene:	CG7432 / 42347	FlyBaseID:	FBgn0038727	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_032903.3	Gene:	Plg / 18815	MGIID:	97620	Length:	812	Species:	Mus musculus

Alignment Length:	507	Identity:	141/507 - (27%)
Similarity:	201/507 - (39%)	Gaps:	117/507 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 PSEEGVLVPVAQGAQQSQQKIKIPTTPRTTTTSTTTEAPITLTPLDQLAEASDEAGTGKDVENYC 335
            |.||  ..||.|...||..: ....|..||.|....::...:.|........:....|.:: |||
Mouse   366 PPEE--QTPVVQECYQSDGQ-SYRGTSSTTITGKKCQSWAAMFPHRHSKTPENFPDAGLEM-NYC 426

  Fly   336 KTPSGRRG------------------RCEDLSSCPALLLNLS------SLRESLCFKSLYVPGVC 376
            :.|.|.:|                  ||.:.......|..:|      |..|:.|   :|..|
Mouse   427 RNPDGDKGPWCYTTDPSVRWEYCNLKRCSETGGSVVELPTVSQEPSGPSDSETDC---MYGNG-- 486

  Fly   377 CPISSSSTVLTTQKPLRLTTRPT---TTTSTTKATQPTKKSTVRPTTRPTSGLVLIPQKKP---- 434
                         |..|..|..|   |......|.:|.:.|...|.|.|.:||.....:.|
Mouse   487 -------------KDYRGKTAVTAAGTPCQGWAAQEPHRHSIFTPQTNPRAGLEKNYCRNPDGDV 538

  Fly   435 --PTTTTTTT------TEVPLEPEGLD-EIGNNIVDPDECGQQEYSTGRIVGGVEAPNGQWPWMA 490
              |...||..      .::||...... |.|...|:|.:|      .||:|||..|....|||..
Mouse   539 NGPWCYTTNPRKLYDYCDIPLCASASSFECGKPQVEPKKC------PGRVVGGCVANPHSWPWQI 597

  Fly   491 AIFLHGPKRTEF----WCGGSLIGTKYILTAAHCTRDSRQKPF-----AARQFTVRLGDIDLSTD 546
            ::      ||.|    :|||:||..:::||||||...|.:..|     .|.:..:|..|:...:.
Mouse   598 SL------RTRFTGQHFCGGTLIAPEWVLTAAHCLEKSSRPEFYKVILGAHEEYIRGLDVQEISV 656

  Fly   547 A----EPSDPVTFAVKEVRTHERFSRIGFYNDIAILVLDKPVRKSKYVIPVCLPKGIRMPPKERL 607
            |    ||::                     .|||:|.|.:|...:..|||.|||.     |...:
Mouse   657 AKLILEPNN---------------------RDIALLKLSRPATITDKVIPACLPS-----PNYMV 695

  Fly   608 PGRR-ATVVGWGTTYYGGKESTSQRQAELPIWRNEDCDRSYF--QPINENFICAGYSDGGVDACQ 669
            ..|. ..:.|||.| .|...:...::|:||:..|:.|:|..:  ..:....:|||...||||:||
Mouse   696 ADRTICYITGWGET-QGTFGAGRLKEAQLPVIENKVCNRVEYLNNRVKSTELCAGQLAGGVDSCQ 759

  Fly   670 GDSGGPLMMRYDSHWVQLGVVSFGNKCGEPGYPGVYTRVTEYLDWIRDHTRD 721
            |||||||:......::..||.|:|..|..|..||||.||:.::|||....|:
Mouse   760 GDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVDWIEREMRN 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7432	NP_650825.2	CLIP	335..378	CDD:197829	13/66 (20%)
		Tryp_SPc	474..715	CDD:214473	84/256 (33%)
		Tryp_SPc	475..718	CDD:238113	85/258 (33%)
Plg	NP_032903.3	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		KR	183..262	CDD:214527
		KR	273..354	CDD:214527
		KR	375..456	CDD:214527	17/82 (21%)
		KR	480..562	CDD:214527	22/99 (22%)
		Tryp_SPc	581..805	CDD:214473	84/256 (33%)
		Tryp_SPc	582..807	CDD:238113	85/257 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4469
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960