DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7432 and F2

DIOPT Version :9

Sequence 1:	NP_650825.2	Gene:	CG7432 / 42347	FlyBaseID:	FBgn0038727	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_034298.1	Gene:	F2 / 14061	MGIID:	88380	Length:	618	Species:	Mus musculus

Alignment Length:	440	Identity:	124/440 - (28%)
Similarity:	176/440 - (40%)	Gaps:	82/440 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 TTSTTTEAPITLTPLDQLAEASDEAGTGKDVENYCKTP-----------SGRRGRCEDLSSCPAL 354
            ||..:...|....|...|::..|.....|.|||:|:.|           :|:.|   |...|
Mouse   230 TTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAGQPG---DFEYC--- 288

  Fly   355 LLNLSSLRESLCFKSLYVPGVCCPISSSSTVLTTQKPLRLTTRPTTTTSTTKATQPTKKSTVRPT 419
              ||:...|::..::.       .:..|....||..... |.....|....:|
Mouse   289 --NLNYCEEAVGEENY-------DVDESIAGRTTDAEFH-TFFNEKTFGLGEA------------ 331

  Fly   420 TRPTSGLVLIPQKKPPTTTTTTTTEVPLEPEGLDEIGNNIVDPDECGQQEYSTGRIVGGVEAPNG 484
               ..||..:.:||....||        |.|.||               .|..||||.|.:|..|
Mouse   332 ---DCGLRPLFEKKSLKDTT--------EKELLD---------------SYIDGRIVEGWDAEKG 370

  Fly   485 QWPWMAAIFLHGPKRTEFWCGGSLIGTKYILTAAHC-TRDSRQKPFAARQFTVRLGDIDLSTDAE 548
            ..||...:|...|:  |..||.|||..:::|||||| ......|.|......||:|....:....
Mouse   371 IAPWQVMLFRKSPQ--ELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYER 433

  Fly   549 PSDPVTFAVKEVRTHERFS-RIGFYNDIAILVLDKPVRKSKYVIPVCLPKGIRMPPKERLPGRRA 612
            ..:.::. ::::..|.|:: |.....|||:|.|.|||..|.|:.|||||....:....| .|.:.
Mouse   434 NVEKISM-LEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLR-AGYKG 496

  Fly   613 TVVGWG------TTYYGGKESTSQRQAELPIWRNEDCDRSYFQPINENFICAGYSDGGV---DAC 668
            .|.|||      ||.....:.:..:...|||.....|..|....|.:|..|||:.....   |||
Mouse   497 RVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDAC 561

  Fly   669 QGDSGGPLMMR--YDSHWVQLGVVSFGNKCGEPGYPGVYTRVTEYLDWIR 716
            :||||||.:|:  :::.|.|:|:||:|..|...|..|.||.|.....||:
Mouse   562 EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQ 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7432	NP_650825.2	CLIP	335..378	CDD:197829	9/53 (17%)
		Tryp_SPc	474..715	CDD:214473	85/253 (34%)
		Tryp_SPc	475..718	CDD:238113	86/255 (34%)
F2	NP_034298.1	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		KR	213..295	CDD:214527	18/72 (25%)
		Thrombin_light	313..360	CDD:286482	15/85 (18%)
		Tryp_SPc	360..610	CDD:214473	85/253 (34%)
		Tryp_SPc	361..613	CDD:238113	86/255 (34%)
		High affinity receptor-binding region which is also known as the TP508 peptide. /evidence=ECO:0000250	548..570		11/21 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4469
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960