Protein Alignment Nup58 and NUP58

DIOPT Version :9

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_054808.1
• Gene: NUP58 / 9818
• HGNCID: 20261
• Length: 599
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 176/560 - (31%)
• Similarity: 251/560 - (44%)
• Gaps: 122/560 - (21%)

  Fly     5 TTNNAIGGATAATGAFAFGARPATTTAPPPSFGAATSTPTFGAAPATTSLFAAPAATPAFGAPAA 69
            :|..|.|| |:..|.|:||...::..:...:||...||.|    |||||   ||::  .||
Human    14 STTVAAGG-TSTGGVFSFGTGASSNPSVGLNFGNLGSTST----PATTS---APSS--GFG---- 64

  Fly    70 TPAFGAPASTPGF--GATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFGAPA 132
            |..||:..:| ||  |.|:|......|...|  .|.||.||              |||..|..
Human    65 TGLFGSKPAT-GFTLGGTNTGIATTITTGLT--LGTPATTS--------------AATTGFSL-- 110

  Fly   133 ATPAFGAPAATSAFGAPAATTAFGAP-ASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAPPA 196
               .|..|||::        |.|..| .||.||..            |.|.|..:|.|.:|
Human   111 ---GFNKPAASA--------TPFALPITSTSASGL------------TLSSALTSTPAAST---- 148

  Fly   197 FGF------GTTATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGLKLG 255
             ||      ||||||..|:...||...:         |....||..:|.|.|:.......||.||
Human   149 -GFTLNNLGGTTATTTTASTGLSLGGAL---------AGLGGSLFQSTNTGTSGLGQNALGLTLG 203

  Fly   256 TTNATTTLGGGGIFSKPAGQAAAPAASTFVGLGGIDVTAT----QPKLGDNKQDGIKIKETQVPD 316
            ||.||:|.|.                   .||||||.:::    ..|.|...:|...:|:..:|.
Human   204 TTAATSTAGN-------------------EGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPP 249

  Fly   317 EIIKTVDGLKAYIKQQKTISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQE 381
            .|.:.|:.|:.::|:||.:..:|.|.|:.....|..:|..||..|...|..::.:...|..::.|
Human   250 VICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIE 314

  Fly   382 TVKAIQSLEMAQRTQDTPAGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAISNPQS 446
            |.:.:::.|:|.|||.||.|||.|..||..||:.||.::|..|..:||||...|.|:...:|...
Human   315 TAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSH 379

  Fly   447 ISPDDLKRGFRQLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRDTTNVFE-------RIDN 504
            |:|.||....:::.::|::||.:|..:|:.|:..||.||..|:..|.|..:|||       :..|
Human   380 ITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQN 444

  Fly   505 PPLPTVEPQRISSGPTPFSNISALMNKSYAAAASSASNAT 544
            .|       |:::||||||.:      ..|||.:.|:..|
Human   445 TP-------RVTTGPTPFSTM------PNAAAVAMAATLT 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	51/172 (30%)
		Nucleoporin_FG2	136..>525	CDD:374260	128/406 (32%)
NUP58	NP_054808.1	Nucleoporin_FG2	3..599	CDD:406391	176/560 (31%)
		14 X 2 AA repeats of F-G	7..579		176/560 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..247		10/52 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154010
Domainoid	1	1.000	192	1.000	Domainoid score	I3236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3861
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52677
OrthoDB	1	1.010	-	-		D379076at33208
OrthoFinder	1	1.000	-	-		FOG0006833
OrthoInspector	1	1.000	-	-		oto90725
orthoMCL	1	0.900	-	-		OOG6_105706
Panther	1	1.100	-	-	LDO	PTHR13437
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.900