DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and NUP116

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_013762.1	Gene:	NUP116 / 855066	SGDID:	S000004650	Length:	1113	Species:	Saccharomyces cerevisiae

Alignment Length:	717	Identity:	162/717 - (22%)
Similarity:	238/717 - (33%)	Gaps:	225/717 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTPTTNNAIG---GATAATGAF----------AFGA-RPATTTAPPPSFGAATSTPTFGAAPAT 51
            ||...|.:..|   |||.:||.|          |||| :|||:..   .||..|:.||.|.  ..
Yeast   215 MFGTGTGSGGGFGSGATNSTGLFGSSTNLSGNSAFGANKPATSGG---LFGNTTNNPTNGT--NN 274

  Fly    52 TSLFAAPAATP---AFGAPAATPAFGAPASTPG--FGATSTAA-----------PAFGTAAATP- 99
            |.||....:..   .||  ....:|||...:.|  ||..:..|           ..||.:.|..
Yeast   275 TGLFGQQNSNTNGGLFG--QQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNANAN 337

  Fly   100 --AFGIPAATSA-FGA-PAATPAFGAAAATPAFGA---PAATPA---------------FGAPAA 142
              |||....|.| ||| ||:...||.:|.:.|||.   |..|..               ||....
Yeast   338 GGAFGQQQGTGALFGAKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQTNQQQSGGGLFGQQQN 402

  Fly   143 TSA----------------FGAPAATTAFGAPASTQASAFGAPAPAVGTV-----APTFSFATPA 186
            ::|                ||...::.|||.| ..|...||: .||.|..     |.||:.....
Yeast   403 SNAGGLFGQNNQSQNQSGLFGQQNSSNAFGQP-QQQGGLFGS-KPAGGLFGQQQGASTFASGNAQ 465

  Fly   187 TSA---------------------PTTAPPAFGFGTTATT-------AAAAMPASLSSGIGSFSF 223
            .::                     .:.:.|...||.|...       .....|...:|..|:
Yeast   466 NNSIFGQNNQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQPFGQNGLQQPQQNNSLFGA--- 527

  Fly   224 PKPQATTAASLNFNTTTTTATA------------------QPFNTGLKLGTTNATTTLGG----- 265
             ||......||..|:||..:..                  ||.:.|| .|:..:.|..||
Yeast   528 -KPTGFGNTSLFSNSTTNQSNGISGNNLQQQSGGLFQNKQQPASGGL-FGSKPSNTVGGGLFGNN 590

  Fly   266 ------------GGIF-SKPA-------GQAAAPAASTFVGLGGI-------DVTATQPKLG--D 301
                        ||:| ||||       ..:.||.||:    |||       :..||....|  .
Yeast   591 QVANQNNPASTSGGLFGSKPATGSLFGGTNSTAPNASS----GGIFGSNNASNTAATTNSTGLFG 651

  Fly   302 NKQDGIKIKETQVPDEIIKTVDGL-----KAYIKQQKTISSDIGRTSTSKFTNVSHEITNLKWAL 361
            ||..|....         .:..||     .:.:......:...|..:||:.||......|
Yeast   652 NKPVGAGAS---------TSAGGLFGNNNNSSLNNSNGSTGLFGSNNTSQSTNAGGLFQN----- 702

  Fly   362 QNMATLVEGS---NQQIRLMRQETVKAIQSLEMAQRTQDTPAGLQFENNAPFQYFQCLVAKYEQD 423
             |.:|...|.   :|..:.|.| :..|:|..:..||       ||.:||.|:...:........:
Yeast   703 -NTSTNTSGGGLFSQPSQSMAQ-SQNALQQQQQQQR-------LQIQNNNPYGTNELFSKATVTN 758

  Fly   424 LIAFRQQIALT-----ERHMHAISNPQSISPDDLKRGFRQLNESFISLAGRLHEVHQRVEEHKEH 483
            .:::..|.:.|     ||...:::|...:.|..|.....:.|.|.:..|      ..:|:.....
Yeast   759 TVSYPIQPSATKIKADERKKASLTNAYKMIPKTLFTAKLKTNNSVMDKA------QIKVDPKLSI 817

  Fly   484 YLNLRRYRLRDTTNVFERIDNPPLPTVE----PQRISSGPTPFSNISALMNKSYAAAASSASNAT 544
            .::.:..::..:....|.:|...|...|    |.:.|     |.|:  :.|:....|:...:|.:
Yeast   818 SIDKKNNQIAISNQQEENLDESILKASELLFNPDKRS-----FKNL--INNRKMLIASEEKNNGS 875

  Fly   545 GN 546
            .|
Yeast   876 QN 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	60/250 (24%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	101/521 (19%)
NUP116	NP_013762.1	Med15	358..>604	CDD:312941	48/252 (19%)
		Nucleoporin_FG2	568..>720	CDD:406391	39/171 (23%)
		Nucleoporin2	970..1108	CDD:397975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930