Protein Alignment Nup58 and NUP116

DIOPT Version :10

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_013762.1
• Gene: NUP116 / 855066
• SGDID: S000004650
• Length: 1113
• Species: Saccharomyces cerevisiae
• Alignment Length: 717
• Identity: 162/717 - (22%)
• Similarity: 238/717 - (33%)
• Gaps: 225/717 - (31%)

  Fly     1 MFTPTTNNAIG---GATAATGAF----------AFGA-RPATTTAPPPSFGAATSTPTFGAAPAT 51
            ||...|.:..|   |||.:||.|          |||| :|||:..   .||..|:.||.|.  ..
Yeast   215 MFGTGTGSGGGFGSGATNSTGLFGSSTNLSGNSAFGANKPATSGG---LFGNTTNNPTNGT--NN 274

  Fly    52 TSLFAAPAATP---AFGAPAATPAFGAPASTPG--FGATSTAA-----------PAFGTAAATP- 99
            |.||....:..   .||  ....:|||...:.|  ||..:..|           ..||.:.|..
Yeast   275 TGLFGQQNSNTNGGLFG--QQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNANAN 337

  Fly   100 --AFGIPAATSA-FGA-PAATPAFGAAAATPAFGA---PAATPA---------------FGAPAA 142
              |||....|.| ||| ||:...||.:|.:.|||.   |..|..               ||....
Yeast   338 GGAFGQQQGTGALFGAKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQTNQQQSGGGLFGQQQN 402

  Fly   143 TSA----------------FGAPAATTAFGAPASTQASAFGAPAPAVGTV-----APTFSFATPA 186
            ::|                ||...::.|||.| ..|...||: .||.|..     |.||:.....
Yeast   403 SNAGGLFGQNNQSQNQSGLFGQQNSSNAFGQP-QQQGGLFGS-KPAGGLFGQQQGASTFASGNAQ 465

  Fly   187 TSA---------------------PTTAPPAFGFGTTATT-------AAAAMPASLSSGIGSFSF 223
            .::                     .:.:.|...||.|...       .....|...:|..|:
Yeast   466 NNSIFGQNNQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQPFGQNGLQQPQQNNSLFGA--- 527

  Fly   224 PKPQATTAASLNFNTTTTTATA------------------QPFNTGLKLGTTNATTTLGG----- 265
             ||......||..|:||..:..                  ||.:.|| .|:..:.|..||
Yeast   528 -KPTGFGNTSLFSNSTTNQSNGISGNNLQQQSGGLFQNKQQPASGGL-FGSKPSNTVGGGLFGNN 590

  Fly   266 ------------GGIF-SKPA-------GQAAAPAASTFVGLGGI-------DVTATQPKLG--D 301
                        ||:| ||||       ..:.||.||:    |||       :..||....|  .
Yeast   591 QVANQNNPASTSGGLFGSKPATGSLFGGTNSTAPNASS----GGIFGSNNASNTAATTNSTGLFG 651

  Fly   302 NKQDGIKIKETQVPDEIIKTVDGL-----KAYIKQQKTISSDIGRTSTSKFTNVSHEITNLKWAL 361
            ||..|....         .:..||     .:.:......:...|..:||:.||......|
Yeast   652 NKPVGAGAS---------TSAGGLFGNNNNSSLNNSNGSTGLFGSNNTSQSTNAGGLFQN----- 702

  Fly   362 QNMATLVEGS---NQQIRLMRQETVKAIQSLEMAQRTQDTPAGLQFENNAPFQYFQCLVAKYEQD 423
             |.:|...|.   :|..:.|.| :..|:|..:..||       ||.:||.|:...:........:
Yeast   703 -NTSTNTSGGGLFSQPSQSMAQ-SQNALQQQQQQQR-------LQIQNNNPYGTNELFSKATVTN 758

  Fly   424 LIAFRQQIALT-----ERHMHAISNPQSISPDDLKRGFRQLNESFISLAGRLHEVHQRVEEHKEH 483
            .:::..|.:.|     ||...:::|...:.|..|.....:.|.|.:..|      ..:|:.....
Yeast   759 TVSYPIQPSATKIKADERKKASLTNAYKMIPKTLFTAKLKTNNSVMDKA------QIKVDPKLSI 817

  Fly   484 YLNLRRYRLRDTTNVFERIDNPPLPTVE----PQRISSGPTPFSNISALMNKSYAAAASSASNAT 544
            .::.:..::..:....|.:|...|...|    |.:.|     |.|:  :.|:....|:...:|.:
Yeast   818 SIDKKNNQIAISNQQEENLDESILKASELLFNPDKRS-----FKNL--INNRKMLIASEEKNNGS 875

  Fly   545 GN 546
            .|
Yeast   876 QN 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	60/250 (24%)
		Nucleoporin_FG2	136..>525	CDD:435043	101/521 (19%)
NUP116	NP_013762.1	FhaB	<184..761	CDD:442443	139/586 (24%)
		Nucleoporin2	970..1108	CDD:461171