Protein Alignment Nup58 and NUP49

DIOPT Version :10

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_011343.1
• Gene: NUP49 / 852703
• SGDID: S000003140
• Length: 472
• Species: Saccharomyces cerevisiae
• Alignment Length: 489
• Identity: 117/489 - (23%)
• Similarity: 196/489 - (40%)
• Gaps: 127/489 - (25%)

  Fly    92 FG--TAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFG--------APAATPAFGAPAATSAF 146
            ||  .|::|||.|:      || .|:..:.|.|....:||        .|:....|||..|.|..
Yeast     2 FGLNKASSTPAGGL------FG-QASGASTGNANTGFSFGGTQTGQNTGPSTGGLFGAKPAGSTG 59

  Fly   147 GAPAA---------TTAFGAPASTQASAFG-APAPAVGTVAPTFSFATPATSA-------PTTAP 194
            |..|:         |.|||..|:|....|| .|.....|....|...:.:.|.       ..|:.
Yeast    60 GLGASFGQQQQQSQTNAFGGSATTGGGLFGNKPNNTANTGGGLFGANSNSNSGSLFGSNNAQTSR 124

  Fly   195 PAFGFGTT--ATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGL----K 253
            ..||...|  ...:::.|..:.:...||    ||...|  ||..||:|::|.||  |.|:    .
Yeast   125 GLFGNNNTNNINNSSSGMNNASAGLFGS----KPAGGT--SLFGNTSTSSAPAQ--NQGMFGAKP 181

  Fly   254 LGTT----NATTTLGGGGIF-SKPAGQAAAPAAST-----------FVGLGGI-----DVTATQP 297
            .||:    ||..|..|||:| |||.|..:...:|.           ....||:     .....||
Yeast   182 AGTSLFGNNAGNTTTGGGLFGSKPTGATSLFGSSNNNNNNNNSNNIMSASGGLFGNQQQQLQQQP 246

  Fly   298 KLGDNKQDGIKIKET------QVPDEIIKTVDGLKAYIKQQKTISSDIGRTSTSKFTNVSHE--I 354
            ::....|:..::..|      ::|.:|.:.::.|..||::|..||..:      |...:.|:  |
Yeast   247 QMQCALQNLSQLPITPMTRISELPPQIRQEIEQLDQYIQKQVQISHHL------KADTIDHDELI 305

  Fly   355 TNLKWALQNMATLVEGSNQQIRLMRQE--TVKAIQSL--EMAQRTQD---------TPAGLQFEN 406
            .::.   :::|.|::..:...:.::|:  .:.:.:||  |....||.         || |.:..:
Yeast   306 DSIP---RDVAYLLKSESATSQYLKQDLKKISSFKSLIDEDLLDTQTFSVLLQQLLTP-GSKISS 366

  Fly   407 NAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAI--------SNPQS--ISPD----------D 451
            |...::||..:..||:.|..:.:.::..|..::.|        :||.|  |:.|          .
Yeast   367 NDLDKFFQKKIHLYEKKLEDYCRILSDIETAVNGIDTDLFGAPNNPNSTAITADLGSSEAENLLQ 431

  Fly   452 LKRGFRQLNES-------FISLAGRLHEVHQRVE 478
            ||.|...:..:       |:.:|.|:..:||:.:
Yeast   432 LKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTK 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	35/129 (27%)
		Nucleoporin_FG2	136..>525	CDD:435043	102/435 (23%)
NUP49	NP_011343.1	Nucleoporin_FG2	29..>289	CDD:435043	68/267 (25%)
		V_Alix_like	<267..465	CDD:353824	43/207 (21%)