Protein Alignment Nup58 and Nup98

DIOPT Version :10

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_112336.2
• Gene: Nup98 / 81738
• RGDID: 71033
• Length: 1816
• Species: Rattus norvegicus
• Alignment Length: 450
• Identity: 118/450 - (26%)
• Similarity: 151/450 - (33%)
• Gaps: 158/450 - (35%)

  Fly     3 TPTTNNAIGGATAATGAF---AFG-------------------------ARPATTTAPPPSFGAA 39
            |.|.....|..|.:.|||   |||                         ::|||:|:....||.:
  Rat    20 TSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTS 84

  Fly    40 TSTPT--FGAAPATTSLFAAPAATPAFGAPAATPAFGAPASTPG-FGATSTAAPAFGTAAATPAF 101
            |.|..  ||.|...||||::.....|...|.....||...|:.| ||.|:|.:..||..:.: .|
  Rat    85 TGTSNSLFGTANTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGNTSGS-LF 148

  Fly   102 GIPAATSA-------FGAPAATPAF---------------------------------------- 119
            |..:.|:|       |..|..|...
  Rat   149 GPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRK 213

  Fly   120 ------GAAAATPAFG-APA---ATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGA-PAPAV 173
                  ||...|..|| :||   ||..|.:....|||......||||    |..:.||. |....
  Rat   214 GPQNQVGAGTTTGLFGSSPATSSATGLFSSSTTNSAFSYGQNKTAFG----TSTTGFGTNPGGLF 274

  Fly   174 G--TVAPTFSFATPATSAPTTAPPAFGFGTTATTAAAAMPASLSSGIGSFSFPKPQATTAASLNF 236
            |  ....|..|:.|...|.||....|.||.|:|   ...|::.:.|:    |...||:....| |
  Rat   275 GQQNQQTTSLFSKPFGQATTTPNTGFSFGNTST---LGQPSTNTMGL----FGVTQASQPGGL-F 331

  Fly   237 NTTTTTATAQPFNTGLKL-----------GTT----NATTTLG------------GGGIF-SKP- 272
            .|.|.|:|...|.||..|           |:|    |..||.|            .||:| :||
  Rat   332 GTATNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFGNKPT 396

  Fly   273 ------------------AGQA---AAPAASTF-VGLG---GIDVTATQPKLGDNKQDGI 307
                              :|.:   :.|||.|. .|||   |..:.|.|..|..|.|..|
  Rat   397 LTLGTNTNTSNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASLFGNNQPKI 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	62/232 (27%)
		Nucleoporin_FG2	136..>525	CDD:435043	64/228 (28%)
Nup98	NP_112336.2	FG repeats 1	1..156		40/136 (29%)
		COG4625	25..>452	CDD:443664	113/439 (26%)
		GLEBS, interaction with RAE1. /evidence=ECO:0000250	157..213		3/55 (5%)
		FG repeats 2	214..480		73/254 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	512..535
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..682
		Nucleoporin2	738..880	CDD:461171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..937
		Nup96	1331..1622	CDD:463462