DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and nup98

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_956979.2	Gene:	nup98 / 777756	ZFINID:	ZDB-GENE-040426-1180	Length:	1814	Species:	Danio rerio

Alignment Length:	747	Identity:	159/747 - (21%)
Similarity:	232/747 - (31%)	Gaps:	248/747 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTPTTNNAIGGATAATGAFA--------FGARPA-------------------TTTAPPPSFGA 38
            ||..:.....||.|...|..:        |||.|.                   |...|...||:
Zfish     1 MFNKSFGAPFGGGTGGFGTSSTFGQPNSGFGATPGGFGSSAFGTTNNTGGLFGNTQNKPGGLFGS 65

  Fly    39 AT-STPT---------FGAAPATT-SLFAA---------PAATPAFGA--PAATPAFGAPASTPG 81
            :| |.|.         |||...|: |||.:         .....||||  |||...||...|:.|
Zfish    66 STFSQPVTSSTSSGFGFGATSGTSNSLFGSTNTGGGGLFSQQNNAFGANKPAAFGNFGTSTSSGG 130

  Fly    82 -FGATSTAAPAFGTAAATPAFGI-------PAATSAFGAPAATPA-------------------- 118
             ||.|:||:..||..:.: .||.       |..|..|..|..:..
Zfish   131 LFGTTNTASNPFGGTSGS-LFGSSSFTAAPPGTTIKFNPPTGSDTMVKGGVTTSINTKHQCITAM 194

  Fly   119 -----------------------------------FGAAA-ATPAFGAPAATPAFGAPAATSAFG 147
                                               ||||| |||:.|    |..||:.|..:.|.
Zfish   195 KEYENKSLEELRLEDYQAGRKGPSNLPMAAGTGGLFGAAAPATPSTG----TGLFGSSAPNTGFN 255

  Fly   148 APAATTAF----GAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAPPAFGFGTTATTAAA 208
            .....|.|    ||..:|..|.|..|...........|...|..||.||....|.||.|::..::
Zfish   256 FGQNKTTFGTSTGAFGTTTGSLFAQPQQQQQQQQQNSSLFKPFGSATTTQNNTFSFGNTSSMVSS 320

  Fly   209 AMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTAT----------------------------- 244
            :.   .:.|:    |....|:.|..|..||.|:|||
Zfish   321 SW---CTKGL----FANTAASQAGGLFGNTNTSTATGFGTGIFGQTNTGFGNVGTQNLFGNKPAG 378

  Fly   245 -------AQPFNTG---------LKLGTTNATTTLG------GGGIF-SKPAGQAAAPAA----S 282
                   |..|.:|         |.|||...|:|.|      |||:| :|.|.....|..    .
Zfish   379 FGTTTTSAPSFGSGPGLFANKPTLTLGTNTNTSTFGFSGTGAGGGLFGNKTAATGLGPVLGAGFG 443

  Fly   283 TFVGLGGIDVTATQPKLGDNK-----------QDGIKIKETQVPDEIIKTVDGLKAYIKQQKTIS 336
            ..||.|...:.....|||...           ..|........|.:.|...|. .|...||..:.
Zfish   444 AGVGTGQTSLFGNNQKLGSTLGSVGTFGAGGFNTGASTLNFGAPQQPIALTDP-SAGAAQQAVLQ 507

  Fly   337 SDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQS-----LEMAQRTQ 396
            ..|...:.|.|.:..        ..:|..:..:...::::.......||:.:     |.....|:
Zfish   508 QQISALAYSPFGDSP--------LFRNPLSDPKKKEERLKPTNPAAQKALTTPTQYKLTPRPATR 564

  Fly   397 DTPAGLQFENNAPFQYFQCLVAKYEQDLI-----AFRQQIALTERHMHAISNPQSISPDDLKRGF 456
            ..|..|....::..|.|..|    :.|.:     ||..:.::.:..:..::| .|:..:.|.|..
Zfish   565 VRPKALSSSGSSKSQLFDGL----DDDELSLNNGAFMPRKSIKKLVLKNLNN-SSLYNNSLNREA 624

  Fly   457 RQL------NESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRDTTNVFERIDNPPLPTVEPQRI 515
            ..|      .::.:||:         ::|.:....|:.| |..|...|.:...||
Zfish   625 DDLASPSEYPQNGLSLS---------LDEGEPREANMER-RGEDDLEVSKFYTNP---------- 669

  Fly   516 SSGPTPFSNISALMNKSYAA--AASSASNATG 545
            .:.|.|.:.:|.|:..:.:.  ...|.|:..|
Zfish   670 ITKPIPHAQLSPLLQDTISEFNMRGSGSHRNG 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	67/278 (24%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	96/475 (20%)
nup98	NP_956979.2	Nucleoporin_FG	39..133	CDD:290362	25/93 (27%)
		Nucleoporin_FG	217..357	CDD:290362	43/150 (29%)
		Nucleoporin_FG	324..>400	CDD:290362	14/79 (18%)
		Nucleoporin2	741..881	CDD:282016
		Nup96	1333..1626	CDD:288926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930