DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and nup58

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_031751882.1	Gene:	nup58 / 595038	XenbaseID:	XB-GENE-6257751	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	556	Identity:	167/556 - (30%)
Similarity:	240/556 - (43%)	Gaps:	98/556 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AFAFGARPA---TTTAPPPSFGAATSTPTFGAAPATTSLFAAPAATPAFGAPAATPAFGAPASTP 80
            ||.|.|:..   |.||....|||      |||.|.|.:      ||...|.    ..|||..:|
Frog    51 AFVFLAQHGLRNTGTAGGLGFGA------FGATPTTQT------ATTGLGG----GLFGAKPAT- 98

  Fly    81 GF--GATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFGAPAATPAFGAPAAT 143
            ||  |..:||...  |..|:..|.|     .|..|       |.:||| |..||.|.:.|..:.:
Frog    99 GFTLGGANTATAT--TTTASTGFSI-----GFNKP-------AGSATP-FSLPATTASSGGLSLS 148

  Fly   144 SAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAPTFSF-ATPATSAPTTAPPAFGFGTTATTAA 207
            ||.            .||||:         |:...|.:. :||||:  |........|.|.|...
Frog   149 SAL------------TSTQAA---------GSSPFTLNLGSTPATT--TAVSTGLSLGGTLTGLG 190

  Fly   208 AAMPASLSSGIGSFSFPKPQATTAA-------SLNFNTTTTTATAQPFNTGLKLG-TTNATTTLG 264
            ..:..||...:  |..|.|..|...       :|..||.......|  ||   || .|....|||
Frog   191 GTLGGSLGGSL--FQNPNPSVTALGQNTLGQNTLGQNTLGQNTLGQ--NT---LGQNTLGQNTLG 248

  Fly   265 GGGIFSKPAGQ----------AAAPAASTFV--GLGGIDVTAT----QPKLGDNKQDGIKIKETQ 313
            ...:.....||          ..||.:....  ||||:|..::    ..|.|...:|....|:..
Frog   249 QNTLGQNTLGQNTLGLGLNLGVVAPVSQVTANEGLGGLDFGSSSDKKSDKAGTRPEDSKAFKDDN 313

  Fly   314 VPDEIIKTVDGLKAYIKQQKTISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLM 378
            :|..:.:.|:..:.::|:||.:..:|.|.|:.....|..:|..|:..|...::.::.::..|..:
Frog   314 LPQLLCQDVENFQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALRQLLSVASSGLQRNSLAIDKL 378

  Fly   379 RQETVKAIQSLEMAQRTQDTPAGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAISN 443
            :.||.:.:::.|:|.|||.||.|||.||.||..||..||.::|..|..:||||...|.|:...||
Frog   379 KIETAQELKNAEIALRTQKTPPGLQHENTAPADYFHTLVQQFEVQLQQYRQQIEELENHLATQSN 443

  Fly   444 PQSISPDDLKRGFRQLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRDTTNVFERIDNPPLP 508
            ...:||.||....::|.::|::||.:|..|::.|:..||.||..|:..|.|:.:|||........
Frog   444 SSHLSPQDLSLAMQKLYQTFVALAAQLQAVNENVKMLKEQYLGYRKAYLGDSADVFEARRAEAKK 508

  Fly   509 TVEPQRISSGPTPFSNISALMNKSYAAAASSASNAT 544
            .....|:::||||||||      ..|||.:.|:..|
Frog   509 WQSAPRVTTGPTPFSNI------PNAAAVAMAATLT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	51/175 (29%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	119/413 (29%)
nup58	XP_031751882.1	Nucleoporin_FG2	94..666	CDD:406391	147/497 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I3957
OMA	1	1.010	-	-		QHG52677
OrthoDB	1	1.010	-	-		D379076at33208
OrthoFinder	1	1.000	-	-		FOG0006833
OrthoInspector	1	1.000	-	-		oto104520
Panther	1	1.100	-	-	LDO	PTHR13437
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080