DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup58 and NCOA5

DIOPT Version :9

Sequence 1:NP_650821.2 Gene:Nup58 / 42342 FlyBaseID:FBgn0038722 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_066018.1 Gene:NCOA5 / 57727 HGNCID:15909 Length:579 Species:Homo sapiens


Alignment Length:217 Identity:51/217 - (23%)
Similarity:87/217 - (40%) Gaps:50/217 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 AATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAP-- 194
            ::|.:...|.:....||.:     ||...||.|:  .|..: |.|.|:   |||..|||.|:.  
Human   377 SSTDSLPGPISRQPLGATS-----GASLKTQPSS--QPLQS-GQVLPS---ATPTPSAPPTSQQE 430

  Fly   195 ------PAFGFGTTATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGLK 253
                  ..|..||....:::|.| |:::|    :.|....:|||:......:..:..||.:.   
Human   431 LQAKILSLFNSGTVTANSSSASP-SVAAG----NTPNQNFSTAANSQPQQRSQASGNQPPSI--- 487

  Fly   254 LGTTNATTTLG------GGGIFSKPAGQAAAPAASTFVGLGGIDVTATQPKLGDNKQDGIKIKET 312
            ||...:...:|      ..|:|.:|:.: .|||:         ::|:.:|.    ...||.....
Human   488 LGQGGSAQNMGPRPGAPSQGLFGQPSSR-LAPAS---------NMTSQRPV----SSTGINFDNP 538

  Fly   313 QVP---DEIIKTVDGLKAYIKQ 331
            .|.   |.:|::...|...:.|
Human   539 SVQKALDTLIQSGPALSHLVSQ 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup58NP_650821.2 PHA03247 <25..195 CDD:223021 20/70 (29%)
Nucleoporin_FG2 136..>525 CDD:374260 50/213 (23%)
NCOA5NP_066018.1 Transcription repression 1..158
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
PRK12678 <32..>135 CDD:237171
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 148..173
HisS <186..256 CDD:223202
LXXLL motif 345..349
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 375..428 20/61 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..537 23/114 (20%)
Transcription activation 458..579 25/124 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 560..579 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0845
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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