Protein Alignment Nup58 and NCOA5

DIOPT Version :10

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_066018.1
• Gene: NCOA5 / 57727
• HGNCID: 15909
• Length: 579
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 51/217 - (23%)
• Similarity: 87/217 - (40%)
• Gaps: 50/217 - (23%)

  Fly   132 AATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAP-- 194
            ::|.:...|.:....||.:     ||...||.|:  .|..: |.|.|:   |||..|||.|:.
Human   377 SSTDSLPGPISRQPLGATS-----GASLKTQPSS--QPLQS-GQVLPS---ATPTPSAPPTSQQE 430

  Fly   195 ------PAFGFGTTATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGLK 253
                  ..|..||....:::|.| |:::|    :.|....:|||:......:..:..||.:.
Human   431 LQAKILSLFNSGTVTANSSSASP-SVAAG----NTPNQNFSTAANSQPQQRSQASGNQPPSI--- 487

  Fly   254 LGTTNATTTLG------GGGIFSKPAGQAAAPAASTFVGLGGIDVTATQPKLGDNKQDGIKIKET 312
            ||...:...:|      ..|:|.:|:.: .|||:         ::|:.:|.    ...||.....
Human   488 LGQGGSAQNMGPRPGAPSQGLFGQPSSR-LAPAS---------NMTSQRPV----SSTGINFDNP 538

  Fly   313 QVP---DEIIKTVDGLKAYIKQ 331
            .|.   |.:|::...|...:.|
Human   539 SVQKALDTLIQSGPALSHLVSQ 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	20/70 (29%)
		Nucleoporin_FG2	136..>525	CDD:435043	50/213 (23%)
NCOA5	NP_066018.1	Transcription repression	1..158
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78
		PRK12678	<32..>135	CDD:237171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..173
		LXXLL motif	345..349
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..428		20/61 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..537		23/114 (20%)
		Transcription activation	458..579		25/124 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..579		1/1 (100%)