DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and Nup98-96

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	188/660 - (28%)
Similarity:	250/660 - (37%)	Gaps:	213/660 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TPTTNNAIGGATAATGAFAFGARPATTTAPPPSFGAATSTPTFGAAP---ATTSLFAAPAATPA- 63
            |.|.|.::.|.|      |||.:|||..|    |||||....|...|   .||:.||||||..:
  Fly   296 TVTENKSMFGTT------AFGQQPATNNA----FGAATQQNNFLQKPFGATTTTPFAAPAADASN 350

  Fly    64 -FGAPAATPAFG--------APAST--PGFGATSTAAPAFGTAAATPAFGIPAATSAFGA-PAAT 116
             ||   |.||||        |||::  |.||.|:|....|||.|     |....::.||| |||.
  Fly   351 PFG---AKPAFGQGGSLFGQAPATSAAPAFGQTNTGFGGFGTTA-----GATQQSTLFGATPAAD 407

  Fly   117 P---AFGAAAATPAFGAPAATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAP 178
            |   |||...|     |.|||..||       |||||.:||.|       ..|| ..||....||
  Fly   408 PNKSAFGLGTA-----ASAATTGFG-------FGAPATSTAGG-------GLFG-NKPATSFAAP 452

  Fly   179 TFSFATPATSAPTTAPPAFGFGT-TATTAAAAMPASL----SSGIGSFSFPKPQATTAASLNFNT 238
            ||.    |||..:|....||..| ||.|......:.|    :||.|.|.     ||:||.||||.
  Fly   453 TFG----ATSTASTPFSNFGLNTSTAATGGGLFNSGLNKPATSGFGGFG-----ATSAAPLNFNA 508

  Fly   239 TTTTA-----TAQPFNTGLKLGTTNATTTLGGGGIFSKPAGQAAAPAASTFVGLGGI-------- 290
            ..|..     ||:| ..||..|   .||||||.|  :.|.|.......::|.|:||.
  Fly   509 GNTGGSLFGNTAKP-GGGLFGG---GTTTLGGTG--AAPTGGLFGGGTTSFGGVGGSLGGGGFGM 567

  Fly   291 --------DVTATQPKLGDNKQDGIKIKETQ-VPDEIIKTVD---GLKAYIKQQKTISSDIGRTS 343
                    .:...||.|      ||.....| :..:|:..|.   |.....|..| :||:...|.
  Fly   568 GTNNSLTGGIMGAQPTL------GIMTPSHQPIHQQILARVTSPYGDSPIFKDLK-LSSEADATR 625

  Fly   344 TSK---------FTNVSHEIT--------------------NLKWALQNMATLVEGSN---QQIR 376
            .:.         .|:..::|:                    :|...|:.....|||.|   ...|
  Fly   626 ATNPAAQQAVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLEEFDASVEGFNLKPSAKR 690

  Fly   377 LMRQETVKAIQ------SLEMAQRT-QDTPAGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALT 434
            |:.:..||:::      |:..|..| |..|.|                |...::..:|...|. :
  Fly   691 LVIKPKVKSVEGGNPSSSIGSAPNTPQSRPKG----------------ATPNKERESFSGAIP-S 738

  Fly   435 ERHMHAISNPQSI----SPDDLKRGFRQLNESFISLAG----RLHEVHQRVEEHKEHYLNLRRYR 491
            |....|.::|.:.    |.|:.:|      ||::....    |.|.:...:::...|
  Fly   739 EPLPPAGNSPGATNGRESQDNGRR------ESWLHPNNLEKVRQHNIQTGMDQGSPH-------- 789

  Fly   492 LRDTTNVFERIDNPPLPTVEPQ-----RISSGP-TPF-----------------SNISALMNKSY 533
             ..|.|  |.:...||.|..|.     .:|:.| .||                 :|.|.|.|:|.
  Fly   790 -NSTLN--ELVPRKPLDTYRPSSTVRLSVSTIPENPFEDQSSTIARRETFTSQQANESVLSNRSN 851

  Fly   534 AAAASSASNA 543
            .|..|:|:.:
  Fly   852 EAEDSAANQS 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	76/188 (40%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	118/488 (24%)
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182	43/109 (39%)
		Nucleoporin2	888..1027	CDD:309287
		Nup96	1484..1762	CDD:314912
		Nucleoporin_FG	<1..74	CDD:316182
		Nucleoporin_FG	50..164	CDD:316182
		Nucleoporin_FG	254..318	CDD:316182	11/27 (41%)
		NupH_GANP	316..>522	CDD:318883	95/246 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840