DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and nup45

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_593058.1	Gene:	nup45 / 2541890	PomBaseID:	SPAC22G7.09c	Length:	425	Species:	Schizosaccharomyces pombe

Alignment Length:	510	Identity:	122/510 - (23%)
Similarity:	178/510 - (34%)	Gaps:	139/510 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TPT-----TNNAIGGATAATGAFA---FGARPATTTAPPPSFGAATSTPTFGAAPATT--SLFAA 57
            ||:     |.|...|.:|.||.|:   ||......|.....||..|. ..||.....|  |||.
pombe     7 TPSFGSTGTQNQNTGTSAGTGLFSSNTFGNNTQANTPASTGFGGVTG-GAFGQTKPQTGGSLFG- 69

  Fly    58 PAATPAFGAPAATPAFGAPASTPG---FGATSTAAPA---FGTAAATPAFGIPAATSAFGAPAAT 116
                   ..|.||      ::|||   ||....|||.   ||.:...|.           ||...
pombe    70 -------NKPNAT------STTPGLNLFGQNPQAAPGGSLFGASTTKPQ-----------APGGL 110

  Fly   117 PAFGAAAATPAFGAPAATPAFGAPAATSAFGAPA--ATTAFGAPASTQASAFGAPAPAVGTVAPT 179
            .......|.||..||..          ..||...  .|.:...||....|.||  ...:||....
pombe   111 FNQNQTQAQPAQAAPTG----------GLFGLSGQNQTQSQTQPAQANTSLFG--QSNIGTTGGL 163

  Fly   180 FSFATPATSAPTTAPPAFGFGTTATTAAAAMPASLSSGIGSF-SFPKPQATTAASLNFNTTTT-- 241
            |....|.||.         ||..:|..|:|         |.| ...:|..:|...|:.||.||
pombe   164 FDQNRPNTST---------FGQFSTQPASA---------GLFGQSTQPSGSTGFGLSNNTQTTPF 210

  Fly   242 --TATAQPFNTGLKLGTTNATTTLGGGGIFSKPAGQAAAPAASTFVGLGGIDVTATQPKLGDNKQ 304
              .|..||..|.|.                |.||                |:.|.....|..|.|
pombe   211 FSAAQQQPSTTQLP----------------SNPA----------------INATTRYSSLNANTQ 243

  Fly   305 DGIKIKETQVPDEIIKTVDGLKAYIKQQKTISSDIGR---TSTSKFTNVSHEITNLKWALQNMAT 366
                           |.:|.|...|..|..::.::..   |.:....:|.:::..::..|.:::|
pombe   244 ---------------KFLDDLDKEIFSQIQLAEELQTKLGTVSELVESVPNDVAEVQRRLSSVST 293

  Fly   367 LVEGSNQQIRLMRQETVKAIQSLEMAQRTQD---TP-AGLQFENNAP-FQYFQCLV--AKYEQDL 424
            .:...:.:|...::...:...:..::.|..|   || |...|.:|.| ..||:...  ||...||
pombe   294 ALLIDSDEIETTKRVVDEDTSNARISSRILDVFKTPGATYPFASNDPLMNYFEQFTENAKKRTDL 358

  Fly   425 IAFRQQIALTERHMHAI-SNPQSISPDDLKRGFRQLNESFISLAGRLHEVHQRVE 478
            .|  ..|...|:|:..: :.||:.||:.|.:..::.::.|::|:.|..:||..|:
pombe   359 YA--ATIGELEQHLEQVETTPQNNSPEALLKTIKEEHKLFMALSNRFAQVHDEVK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	45/179 (25%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	80/361 (22%)
nup45	NP_593058.1	Nucleoporin_FG2	12..>414	CDD:292589	120/505 (24%)
nup45	NP_593058.1	Nucleoporin_FG	43..142	CDD:290362	33/134 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52677
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13437
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040