DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and Ncoa5

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_659141.1	Gene:	Ncoa5 / 228869	MGIID:	2385165	Length:	579	Species:	Mus musculus

Alignment Length:	207	Identity:	56/207 - (27%)
Similarity:	81/207 - (39%)	Gaps:	35/207 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PTTNNAIGGATAATGAFAFGARPATTTAPPPSFGAATSTPTFGAAPATT---------SLFAAPA 59
            |.:...:|.|:.::......::|..:....||   ||.||   |||.|:         |||.:
Mouse   385 PISRQPLGAASGSSLKSQPSSQPLQSGQVLPS---ATPTP---AAPPTSQQELQAKILSLFNS-- 441

  Fly    60 ATPAFGAPAATPAFGAPASTPGFGATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAA 124
                 ||.||..:..:|:...|    |:....|.|||.:.....|.|:..........|..|...
Mouse   442 -----GAVAANSSSASPSVATG----SSQNQNFSTAANSQPQQRPQASGNQPPNIVGQAGSARNM 497

  Fly   125 TPAFGAPAATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPA--PAVGTV---APTFSFAT 184
            .|..||| :...||.|::..   |||:|.|...|.|:....|..|:  .|:.|:   .|..|...
Mouse   498 GPRPGAP-SQGLFGQPSSRL---APASTMASQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLV 558

  Fly   185 PATSAPTTAPPA 196
            ..|:|....|.|
Mouse   559 SQTAAQVGRPQA 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	51/183 (28%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	20/66 (30%)
Ncoa5	NP_659141.1	Transcription repression	1..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..172
		HisS	<186..256	CDD:223202
		LXXLL motif	345..349
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..428		14/48 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..529		25/90 (28%)
		Transcription activation	458..579		34/121 (28%)
		PRK14971	<459..>543	CDD:237874	25/87 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900