Protein Alignment Nup58 and Nup62

DIOPT Version :9

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_444304.1
• Gene: Nup62 / 18226
• MGIID: 1351500
• Length: 526
• Species: Mus musculus
• Alignment Length: 535
• Identity: 144/535 - (26%)
• Similarity: 206/535 - (38%)
• Gaps: 137/535 - (25%)

  Fly    11 GGATAATGAFAFGARPATTTAPPPSF-----GAATSTPTFG------AAPATTSLFAAPAATPAF 64
            ||..|..|.|.||.....||.|...|     |..|....||      |...:||||:....||.
Mouse     7 GGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLTTQTPT- 70

  Fly    65 GAPAATPAFGAPASTPGFGAT------STAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAA 123
               ..||.|.. .:||..|.|      ||...:...||||||   .|.|.:||..::|.....::
Mouse    71 ---TQTPGFNF-GTTPASGGTGFSLGISTPKLSLSNAAATPA---TANTGSFGLGSSTLTNAISS 128

  Fly   124 ATPAFGAPAATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVA-PTF---SFAT 184
            .:.:....|.|......:.|||....:...:|.:.:::|..|.|....:||:.| ||.   |..|
Mouse   129 GSTSNQGTAPTGFVFGSSTTSAPSTGSTGFSFTSGSASQPGASGFSLGSVGSSAQPTALSGSPFT 193

  Fly   185 PATSAPTTA---PPAFGFGTTATTAA--------AAMPASL-----------------SSGIGSF 221
            |||...|||   .||....|.|||:|        ||.|||.                 |:|...|
Mouse   194 PATLVTTTAGATQPAAAAPTAATTSAGSTLFASIAAAPASSSATGLSLPAPVTTAATPSAGTLGF 258

  Fly   222 SFPKPQATTAASLNFNTTTTTATAQPFNTGLKLGTTN-----ATTTLGGGGIFSKP---AGQA-- 276
            |...|.|...||....|||||.|           ||.     |:||..|..:..||   ||.:
Mouse   259 SLKAPGAAPGASTTSTTTTTTTT-----------TTTAAAAAASTTTTGFALSLKPLVSAGPSSV 312

  Fly   277 ---AAPAASTFVGLGGIDVTATQPKLGDNKQDGIKIK-ETQVPDEIIKTVDGLKAYIKQQKTISS 337
               |.||:||..|      |||.|.:...:.:.:..| ..::.|:        :.:..||.|..:
Mouse   313 AATALPASSTAAG------TATGPAMTYAQLESLINKWSLELEDQ--------ERHFLQQATQVN 363

  Fly   338 DIGRT---STSKFTNVSHEITNLKW-----------------ALQNMATLVEGSNQQ----IRLM 378
            ...||   :..|.|::..|:..:|.                 .|:::.:.:|.|.::    |.|.
Mouse   364 AWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQ 428

  Fly   379 -----RQETVKAIQSLE-----MAQRTQD-----TPAGLQFENNAPFQYFQCLVAKYEQDLIAF- 427
                 |::|.|..::::     |||..:|     ..||...:.:.|.|.. |.:.....|.:.:
Mouse   429 HADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQI-CKILNAHMDSLQWV 492

  Fly   428 RQQIALTERHMHAIS 442
            .|..||.:|.:...|
Mouse   493 DQSSALLQRRVEEAS 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	57/193 (30%)
		Nucleoporin_FG2	136..>525	CDD:374260	100/393 (25%)
Nup62	NP_444304.1	5 X 2 AA repeats of F-G. /evidence=ECO:0000250|UniProtKB:P37198	6..144		44/144 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..82		12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..148		2/19 (11%)
		Nsp1_C	318..433	CDD:282867	25/128 (20%)
		Required for centrosome localization. /evidence=ECO:0000250|UniProtKB:P37198	332..462		23/137 (17%)
		DUF4795	366..>505	CDD:292662	28/139 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030