DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and npp-10

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001367842.1	Gene:	npp-10 / 175852	WormBaseID:	WBGene00003796	Length:	1678	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	179/785 - (22%)
Similarity:	270/785 - (34%)	Gaps:	288/785 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NNAIGGATAATGAFA-----------FGARPATTTAPPPSFGAATSTPT---FGAAPATTSLF-- 55
            :::.||.::.:|.|.           || :||..:.....||||.:.|.   ||||..|:|:|
Worm    10 SSSFGGGSSGSGLFGQNNQNNQNKGLFG-QPANNSGTTGLFGAAQNKPAGSIFGAASNTSSIFGS 73

  Fly    56 -----------------------------AAPAATPAFG-----------------APAATPAFG 74
                                         ||||::..||                 ||:....||
Worm    74 PQQPQNNQSSLFGGGQNNANRSIFGSTSSAAPASSSLFGNNANNTGTSSIFGSNNNAPSGGGLFG 138

  Fly    75 A------------PAST--------------------------------------------PGFG 83
            |            |.|:                                            ||.|
Worm   139 ASTVSGTTVKFEPPISSDTMMRNGTTQTISTKHMCISAMSKYDGKSIEELRVEDYIANRKAPGTG 203

  Fly    84 ATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFGAPAATPAFG---------- 138
            .|||....||.:..|...|......:..|...|..||.|:.:..||...:|...|
Worm   204 TTSTGGGLFGASNTTNQAGSSGLFGSSNAQQKTSLFGGASTSSPFGGNTSTANTGSSLFGNNNAN 268

  Fly   139 -APAATSAFGA-PAATTAFGAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAPPAFG--- 198
             :.|:.|.||| ||.::.||:.|:|.||.||..     |.:..|....|.|:   |....||
Worm   269 TSAASGSLFGAKPAGSSLFGSTATTGASTFGQT-----TGSSLFGNQQPQTN---TGGSLFGNTQ 325

  Fly   199 --------FGTTATTA------AAAMPASLSSGIGSF--------SFPKP-QATTAASLNFNTTT 240
                    ||.|.||.      |...|...|||. ||        :|.:| .|.|..||..||:|
Worm   326 NQNQSGSLFGNTGTTGTGLFGQAQQQPQQQSSGF-SFGGAPAATNAFGQPAAANTGGSLFGNTST 389

  Fly   241 TTATAQPF------NTGLKLGTTNATTTLG------GGGIF----SKPAGQ-------------- 275
            ....:..|      :||...|.|..|||..      |||:|    :||.|.
Worm   390 ANTGSSLFGAKPATSTGFTFGATQPTTTNAFGSTNTGGGLFGNNAAKPGGLFGNTTNTGTGGGLF 454

  Fly   276 AAAPAASTFVGLGGIDVTATQP---KLGDNKQDGIKIKETQVPDEIIKTVDGLKAYIKQQKTISS 337
            .:.|.||: .||.|.:..||||   ..|:..|..|.:::...|..:|    |:.|.:.|.:....
Worm   455 GSQPQASS-GGLFGSNTQATQPLNTGFGNLAQPQIVMQQQVAPVPVI----GVTADVLQMQANMK 514

  Fly   338 DIGRTSTSKFTNVSH-EITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQ--SLEMAQRTQDTP 399
            .:    .|:.||..: :...||:   |....::|.:......||....|.:  :|..:...||:
Worm   515 SL----KSQLTNAPYGDSPLLKY---NANPEIDGKSSPASTQRQLRFLAAKKGALSSSSDAQDS- 571

  Fly   400 AGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAISNPQSISPDDLKRGFRQLNESF- 463
                       .:....::|...||.....:.|...:.::..|..   :|..|.||.|  |.:|
Worm   572 -----------SFIIPPISKVMSDLSPAVTRSADVTKDLNYTSKE---APPSLARGLR--NSTFN 620

  Fly   464 --ISLAGR-LHE---VHQRVEEHKEHYLN-----------LRRYRLR--------DTTNV--FER 501
              :||..| :||   :.:.::...:..:|           :||..|:        |::.|  ..|
Worm   621 PNMSLTNRSVHESSALDKTIDSALDASMNGTSNRLGVRGSVRRSNLKQLDMSLLADSSRVGRESR 685

  Fly   502 IDNP-PLPTV-EPQR----ISSGPT------------------PFSNISALMN-----KSYAAAA 537
            :.:| .||.: |.:|    ::|.|.                  |..|:....:     :..:||.
Worm   686 VADPDALPRISESERRQDVVTSTPAVDPVQAVIQRHNDRNRDPPSLNLDTTCDEHTGLEPVSAAT 750

  Fly   538 SSASN 542
            |||::
Worm   751 SSAAS 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	66/288 (23%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	122/514 (24%)
npp-10	NP_001367842.1	Nucleoporin_FG	59..146	CDD:404514	18/86 (21%)
		Nucleoporin_FG	110..240	CDD:404514	21/129 (16%)
		Nucleoporin_FG	237..334	CDD:404514	29/104 (28%)
		Nucleoporin_FG	305..431	CDD:404514	38/129 (29%)
		Nucleoporin_FG	407..>487	CDD:404514	24/80 (30%)
		Nucleoporin2	777..919	CDD:397975
		Nup96	1259..1512	CDD:403363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940