Protein Alignment subdued and IST2

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_009643.2
• Gene: IST2 / 852382
• SGDID: S000000290
• Length: 946
• Species: Saccharomyces cerevisiae
• Alignment Length: 693
• Identity: 135/693 - (19%)
• Similarity: 238/693 - (34%)
• Gaps: 239/693 - (34%)

  Fly   286 LTNKIPGMSVV-NRSTKSVFSSLKHVFQFFLRNIYVDEEIFP----KRAHRFTAIYSRDKEYLFD 345
            :|:..|...:| |:::.:...||...|    :.:.:...|.|    :.::.|..|:..:.:.||.
Yeast     5 ITSLDPNCVIVFNKTSSANEKSLNVEF----KRLNIHSIIEPGHDLQTSYAFIRIHQDNAKPLFS 65

  Fly   346 IRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRA 410
            ..|:..|                             ||.:|         |.||.|:::.
Yeast    66 FLQNLDF-----------------------------IESII---------PYHDTELSDD----- 87

  Fly   411 LLYK-------HWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGV-ICFLYS 467
             |:|       .....||.|....|.::..  ..|..||||:|..|...|:..|..|: |.||
Yeast    88 -LHKLISISKSKILEAPKQYELYNLSNLTN--NPKQSLYFAFLQNYIKWLIPFSFFGLSIRFL-- 147

  Fly   468 WFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWAT 532
                                         .||            ||..::.    :::|...|..
Yeast   148 -----------------------------SNF------------TYEFNST----YSLFAILWTL 167

  Fly   533 LFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPA 597
            .|...|                           |.:.|.....|:...::..  |:.|.:.|..|
Yeast   168 SFTAFW---------------------------LYKYEPFWSDRLSKYSSFS--TIEFLQDKQKA 203

  Fly   598 TVFSFSVVLLL------IALAFVA-LLAVVVYRMSMLAALK-VGASPMTTSSAIVLATASAAFVN 654
            ...:.||::|.      :||.|.| ||:..:|..::...:| :...||.:..:.:.......|..
Yeast   204 QKKASSVIMLKKCCFIPVALLFGAILLSFQLYCFALEIFIKQIYNGPMISILSFLPTILICTFTP 268

  Fly   655 LCLLYILNYMYN-HLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGH- 717
                 :|..:|| :..|.:|:.|...:......|...|.:::.|::.|..:. |..|....:||
Yeast   269 -----VLTVIYNKYFVEPMTKWENHSSVVNAKKSKEAKNFVIIFLSSYVPLL-ITLFLYLPMGHL 327

  Fly   718 -PGEY-NKLF--------------DY-----RQEECSSGGCLTELCIQLAIIMVGKQAFNTILEV 761
             ..|. .|:|              |:     |.|:            |....:|..|.....:|.
Yeast   328 LTAEIRTKVFNAFSILARLPTHDSDFIIDTKRYED------------QFFYFIVINQLIQFSMEN 380

  Fly   762 YLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDER--------------W--MRDFKLLDWGAR-GL 809
            ::|..        |.:::...|.|||:..|.|.              |  ::.::...|||. .|
Yeast   381 FVPSL--------VSIAQQKINGPNPNFVKAESEIGKAQLSSSDMKIWSKVKSYQTDPWGATFDL 437

  Fly   810 FPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHK----------RPVS--- 861
            ...:.:::||:|::.:|...:|||||..|:.|::..::|.:|.:.:.|          :|.|
Yeast   438 DANFKKLLLQFGYLVMFSTIWPLAPFICLIVNLIVYQVDLRKAVLYSKPEYFPFPIYDKPSSVSN 502

  Fly   862 -QRVRDIGVW------YRILDCIGKLSVITNGFIIAFTSDMIP 897
             |:: .:|:|      :.||.|     |||......:.|..||
Yeast   503 TQKL-TVGLWNSVLVMFSILGC-----VITATLTYMYQSCNIP 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	27/153 (18%)
		Anoctamin	431..1007	CDD:461349	107/536 (20%)
IST2	NP_009643.2	Anoctamin	122..588	CDD:480725	106/526 (20%)
		PRK13335	779..>880	CDD:139494