DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano9

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_006536311.2	Gene:	Ano9 / 71345	MGIID:	1918595	Length:	765	Species:	Mus musculus

Alignment Length:	854	Identity:	275/854 - (32%)
Similarity:	434/854 - (50%)	Gaps:	138/854 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 ENTEKRRVF------EANLISQGLEVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCN 269
            |:.|..::|      :..|:..| ..:....|| |...:.|.|:.|:    |.|......:.|.|
Mouse    20 EDDESSQIFMGPEGDQLPLVEMG-SCKPEASDQ-WDCVLVADLQTLK----IQKHAQKQLQFLEN 78

  Fly   270 LRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTA 334
            |.        .|..|:...|         ..|.||..::           .|.::..|  :|...
Mouse    79 LE--------SNGFHFKMLK---------DQKKVFFGIR-----------ADSDVIDK--YRTLL 113

  Fly   335 IY-----SRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAA 394
            :.     |||::        .|.....|.|||.|:::.:..|...       .|.|:.:||:...
Mouse   114 MNPEDSGSRDEQ--------SFNIATTRIRIVSFVVNNKLKPGDT-------FEDLVKDGVFETM 163

  Fly   395 YPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIV 459
            :.||.||..        |...||.....:..||:|:|:||||.|:.|||.|||:|||||:.|::|
Mouse   164 FLLHKGEQN--------LKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVV 220

  Fly   460 GVICFLYSWFSLKNYVPV-KDICQSGNTNITMCPLCDWCN-FWDLKETCNYAKVTYLIDNPSTVF 522
            |:|.|| |.|:|.:...: |:||.:  .:|.||||.|..: :..|.|.|.:||:|:|.||..||.
Mouse   221 GLIVFL-SGFALFDSSQISKEICSA--NDIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDNEGTVL 282

  Fly   523 FAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPT 587
            ||:||:.|||:|||:|||..|.....|.|..:|..||.      ..||.|              .
Mouse   283 FAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEE------MALELI--------------N 327

  Fly   588 VPFWRMKLPATVFSFSVVLLLIALAFVALL-----AVVVYRMSMLAALKVGASPMTTSSAIVLAT 647
            .|.:::|.....:..|.::|:::|..:.|:     .:||||: :..||.........::|:|:
Mouse   328 SPHYKLKDHRHSYLSSTIILILSLFMICLMIGMAHVLVVYRV-LAGALFSSLVKQQVTTAVVV-- 389

  Fly   648 ASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKG 712
             :.|.|:..::.|:..:..::|..|.:.|...|.::.:...|:|.::|||..:::|:.||||..|
Mouse   390 -TGAVVHYIIIVIMTKVNKYVALKLCKFEESGTFSEQERKFTVKFFILQFFAHFSSLIYIAFILG 453

  Fly   713 KFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMF---WRKVLAI 773
            :..||||:..:|.. ::.|||...||:.:|.||:||||..||..:..:|...|:.   ||.:.|.
Mouse   454 RINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQMAIIMGLKQTLSNCVEYLCPLLAHKWRLMWAS 518

  Fly   774 QVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFAL 838
            :.|     :.:.:|:.   :.|.|::.:.......||.|::||::||||.|||||||||||..||
Mouse   519 KHG-----HMSKDPEL---KEWQRNYYMNPINTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLAL 575

  Fly   839 LNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYR- 902
            .:|::|:||||.|::...:|.|.::.:|||.|.::|:.||.|:||.||.:|||||:.|||:||:
Mouse   576 FSNLVEIRLDAIKMVRLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKY 640

  Fly   903 HY----VNKQGT---LDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTL 960
            ||    .|:..|   |..|:|.:||.|..........:.|. .|:|.|||.|:|    :...|.|
Mouse   641 HYGPCRTNRTFTDDCLTNYVNHSLSVFYTKHFNDHSRMEGQ-ENVTVCRYRDYR----NEHDYNL 700

  Fly   961 SSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARF 1025
            |..|:.|||.||.||::||:|...:.::..|.:||:..::::::.:|.|       |:..||.||
Mouse   701 SEQFWFILAIRLTFVILFEHFALCIKLIAAWFVPDVPQKVKNEVLQEKY-------DRIRHRMRF 758

  Fly  1026 ERAKRSSSV 1034
              :.||:.|
Mouse   759 --SSRSTDV 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	47/227 (21%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	216/594 (36%)
Ano9	XP_006536311.2	Anoct_dimer	<123..189	CDD:374413	20/88 (23%)
Ano9	XP_006536311.2	Anoctamin	192..747	CDD:367984	216/594 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920