DRSC/TRiP Functional Genomics Resources

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Protein Alignment subdued and ANO8

DIOPT Version :10

Sequence 1:NP_001189248.1 Gene:subdued / 42340 FlyBaseID:FBgn0038721 Length:1099 Species:Drosophila melanogaster
Sequence 2:NP_066010.1 Gene:ANO8 / 57719 HGNCID:29329 Length:1232 Species:Homo sapiens


Alignment Length:1030 Identity:219/1030 - (21%)
Similarity:338/1030 - (32%) Gaps:444/1030 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 RLRNAAHYLTNKIPGMSVVNRSTKSVFSSL-----KHVFQFFLRNIYV--DEEIFPKRAHRFTAI 335
            ||..|..||.:....|..|......|..:.     .|...:.|.:|.|  .|.|...|.||.|..
Human    42 RLLQAGRYLVSHKAWMKTVPTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRA 106

  Fly   336 Y-----------------------------------SRDKEYLFD-IRQDC-FFTTAVRSRIVEF 363
            |                                   |.::::::: :..:. |||:..|..|:.|
Human   107 YAFFVTATYESLLRGADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRF 171

  Fly   364 ILDRQRFPAKN---QHDMAF-----GIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVP 420
            .|  |...||.   .|::.|     .|..|.|.|:....:|:|:..|...      |.|.|  |.
Human   172 WL--QNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNR------LMKSW--VQ 226

  Fly   421 KWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGN 485
            .....||||||.:||||||.:||||||:||..::..::.|.:  ||:                  
Human   227 AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSV--LYT------------------ 271

  Fly   486 TNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRW- 549
                         |.:..:|..         :.|.|.||:|...|:|||||.|||..||:.::| 
Human   272 -------------FTEADQTSR---------DVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWG 314

  Fly   550 --DLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSF--SVVLLLIA 610
              |..|..|  |.||||:..      ..|:..:|..:|...|.|:..|    |..  |:.|.|..
Human   315 TLDSPGEAV--EEPRPQFRG------VRRISPITRAEEFYYPPWKRLL----FQLLVSLPLCLAC 367

  Fly   611 LAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYM----YNHLAEY 671
            |..|.||.:..:::..| .|.|...|..           |.|:...:|.:|..:    |..||.:
Human   368 LVCVFLLMLGCFQLQEL-VLSVKGLPRL-----------ARFLPKVMLALLVSVSAEGYKKLAIW 420

  Fly   672 LTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGG 736
            |.::|.:|.::.::..|.:|:.|.||||.|.|:|||.|:             |.|..:       
Human   421 LNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFY-------------LKDMER------- 465

  Fly   737 CLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFN-----------NTPNP--- 787
             |.|:   ||.:::.:|....:.||..|..:|::...::||..::.           ..|.|   
Human   466 -LKEM---LATLLITRQFLQNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRL 526

  Fly   788 ----------------------------------------------------------------- 787
                                                                             
Human   527 EPQADEGGGGGSGGGGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEE 591

  Fly   788 --DKAKDERWMRDFKLLDWGAR----------------------------------GL------- 809
              ::.:||....:..|||.|.|                                  ||       
Human   592 DEEEEEDEEEGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTL 656

  Fly   810 ----------------------------------------------------------------- 809
                                                                             
Human   657 AEEDDEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDPP 721

  Fly   810 -----------------------FPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKK 851
                                   |.:|.||.:|:|:|.:|.:|||||...||:||::|:|.||.|
Human   722 EEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFK 786

  Fly   852 LLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLN 916
            |.|..:||..|||..||.|.::::.:|.|:::.|.::|                           
Human   787 LCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLI--------------------------- 824

  Fly   917 FTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENF 981
                           ...|.|..:         .|..|||...:|             |||.|:|
Human   825 ---------------GQCGQLQRL---------FPWLSPEAAIVS-------------VVVLEHF 852

  Fly   982 VALVMILVRWCIPDMSVELRDQI------RREVYVTNEIIIDQEAHRARFERAKR 1030
            ..|:..|:...|||:...:.:::      |||.:..:|   .|..||.:.::.:|
Human   853 ALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHE---RQAQHRYQQQQRRR 904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
subduedNP_001189248.1 Anoct_dimer 186..428 CDD:465044 44/201 (22%)
Anoctamin 431..1007 CDD:461349 164/800 (21%)
ANO8NP_066010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
Anoctamin 237..>497 CDD:461349 97/349 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..650 8/125 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 681..728 0/46 (0%)
Anoctamin <717..877 CDD:461349 53/223 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..970 5/20 (25%)
PHA03307 <940..>1120 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 997..1152
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1232
Blue background indicates that the domain is not in the aligned region.

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