DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ANO2

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_001265525.1	Gene:	ANO2 / 57101	HGNCID:	1183	Length:	1003	Species:	Homo sapiens

Alignment Length:	1025	Identity:	375/1025 - (36%)
Similarity:	560/1025 - (54%)	Gaps:	159/1025 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 SASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGN 159
            |..|.|..|..:..:..:.....|::|   .|||.|.:...|| :|..|.
Human    15 SPRRLSPQAGSRGGQGPKHGQQCLKMP---GPRAPGLQGGSNR-DPGQPC--------------- 60

  Fly   160 VGGVYDDRECSCPREFYQRGE-IN-----TSLFFEDCVRSIDFVLAYRI---------------- 202
              |....|..|....:....| ::     :.:.|.|..|.:|:||||..
Human    61 --GGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSL 123

  Fly   203 -------NAHEP---------------TELENTEKRRVFEANLISQGLEVESSQKDQIW---FVK 242
                   ...||               .|.|..|:|..||.||:..|||:|...:::..   ||:
Human   124 AIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVR 188

  Fly   243 IHAPLEVLRRYAEILKLRMPMKESLCNLR----ISER-SNRLRNAAHYLTNKIPGMSVVNRSTKS 302
            ||||.:||.|.||.||:::|.|:.:..::    |::: |..|:..:.:|..::|..|  |...|:
Human   189 IHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHS--NNKMKN 251

  Fly   303 VFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQ-DCFFTTAVRSRIVEFILD 366
            :                    .:|         :||:|.||::|:: |.||..|.|||||..||.
Human   252 L--------------------SYP---------FSREKMYLYNIQEKDTFFDNATRSRIVHEILK 287

  Fly   367 RQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEI---TETGTMRALLYKHWASVPKWYRYQPL 428
            |   .|.::.:...||..|||..:|.|||||||||.   .:....|.|||:.||....:|::||:
Human   288 R---TACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPI 349

  Fly   429 DDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPL 493
            |.|::|||.||||||||||.||..|:.:|::|||.|||...:::..:|.:::|...|. .|||||
Human   350 DLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNA-FTMCPL 413

  Fly   494 CD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVH 557
            || .|::|:|...|..|:.::|.|||:||||::||:.|||:|||.|||....:.:.|||||.:..
Human   414 CDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEE 478

  Fly   558 E----EHPRPQYLARLEH--IPPTRVDYVTNIKEPTVP----------FWRMKLPATVFSFSVVL 606
            |    ||.||:|..::..  :..:....|..::..|..          .|:.:.|..:.:|:.:|
Human   479 EERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASIL 543

  Fly   607 LLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEY 671
            .:|||.|..:..|:|||::..|||.:..:  |.|:..|..||:|..:||.::.||:.:|..:|::
Human   544 FMIALTFSIVFGVIVYRITTAAALSLNKA--TRSNVRVTVTATAVIINLVVILILDEIYGAVAKW 606

  Fly   672 LTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSG 735
            ||::|:.:|:..|::.|.||.:||:|||.|:.|||:|||||:|||.||.|..:|| ||.|||:.|
Human   607 LTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 671

  Fly   736 GCLTELCIQLAIIMVGKQAF-NTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKD------- 792
            |||.||||||:|||:|||.. |.|.|:.:|.           |.:||....:..:|.:
Human   672 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPK-----------LKKLFRKLKDETEAGETDSAHSK 725

  Fly   793 --ERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTH 855
              |:|..|:.|..:  .||.|||:||::|:||||:|||:|||||.||||||::|:||||||.:|.
Human   726 HPEQWDLDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTE 788

  Fly   856 HKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLS 920
            .:||.:.|.:|||:|:.||..|||.|||:|.|:||.|||.||||||::..:..|||.|::|.|||
Human   789 LRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLS 853

  Fly   921 EFKV--IDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVA 983
            .|.|  :...|....:.....:..||:.|:|.||.:|..|..|..::.||:.||.||::|:|.|.
Human   854 FFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVM 918

  Fly   984 LVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARF--ERAKRS 1031
            .:.:||.|.|||:..::.|||::|..:..:..:.:|..:.:.  |.|.||
Human   919 FLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRS 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	88/291 (30%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	261/605 (43%)
ANO2	NP_001265525.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		16/73 (22%)
		Anoct_dimer	91..349	CDD:292796	88/291 (30%)
		Anoctamin	352..943	CDD:282414	261/606 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1003		4/8 (50%)
		DLG4 binding (PDZ)	1001..1003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I317
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I910
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880