DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano2b

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_001314787.1	Gene:	ano2b / 566373	ZFINID:	ZDB-GENE-060503-62	Length:	1065	Species:	Danio rerio

Alignment Length:	1042	Identity:	368/1042 - (35%)
Similarity:	549/1042 - (52%)	Gaps:	221/1042 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTS 184
            :.||.....|..:.:||:.:.:|      .|.|.|               ..||:         .
Zfish    58 IEESLHHSDNMLQTSGNKIHVAN------NMMDMD---------------QDPRK---------R 92

  Fly   185 LFFEDCVRSIDFVL-------------------------AYRINAHE------------------ 206
            |:|.|..|.:|:||                         :|.:...|
Zfish    93 LYFADGRRKVDYVLVFHYRKRSSIRGSPSQHRLSIISNGSYHLGVEEKDPEGGKEEPAEVVVDVG 157

  Fly   207 ---PTELENTEKRRVFEANLISQGLEVESSQKDQIW---FVKIHAPLEVLRRYAEILKLRMPMKE 265
               |.|.|....|..||.:|...|||:|..::::..   |:::|||.:||.|.||.||:::..|:
Zfish   158 PPDPAEGEKIMIREEFEGSLKDAGLEIERDKENKAHGHAFIRLHAPWQVLSREAEFLKIKVQTKK 222

  Fly   266 SLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAH 330
            |                  |...:..|::.   :...|:..|...||             ||..|
Zfish   223 S------------------YELREEKGLAA---TMNEVWRKLNQPFQ-------------PKVPH 253

  Fly   331 R---------FTAIYSRDKEYLFDIR-QDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERL 385
            :         .|..:||||.:|::|: :|.||..|.|||||..||.|   .|..:.....||..|
Zfish   254 QEQENSRTKFLTHCFSRDKLHLYNIQSKDTFFDNATRSRIVYEILRR---TACTRTCQTMGITTL 315

  Fly   386 IAEGVYSAAYPLHDGEITETG-----TMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAW 445
            ||.|||.:|:|||||:...:|     ..|.||:..||....:|:|||:|.|::|||.||||||||
Zfish   316 IANGVYDSAFPLHDGDFHSSGQAEGKNERQLLHDEWARYGAFYKYQPIDLIRKYFGEKIGLYFAW 380

  Fly   446 LGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETCNYA 509
            ||.||.:|:.||:||:|.|.|.|.:::..||.:::|.. ..|.||||||| .|::|.|...|..|
Zfish   381 LGVYTQLLIPASVVGIIVFFYGWATVETNVPSQEMCDE-TQNFTMCPLCDRVCDYWQLSTACGTA 444

  Fly   510 KVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQY--------- 565
            :.::|.|||:|||||:|||.||.:|||.|||....:.:.|||||.:..||||||:|
Zfish   445 RASHLFDNPATVFFAIFMSLWAAMFLEHWKRRQISLNYSWDLTGMEEEEEHPRPKYETILLQKRQ 509

  Fly   566 -------------------------------LARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATV 599
                                           |:.:....||..:.:|         ||.:||..:
Zfish   510 RKKKNKKNKNEPERVVDESGELGKDKWRQRLLSAMAAGNPTGHEKLT---------WRDRLPGYL 565

  Fly   600 FSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYM 664
            .:.|.:|.:..:...|:.:|::||:::.|.:.:...|...|:..|..||:|..:||.::.||:.:
Zfish   566 INISSILFMFGVTCSAVFSVIIYRITISALMAMSPDPDVKSNVRVTVTATAVIINLVVILILDEI 630

  Fly   665 YNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF-DYR 728
            |..:|.:|||||:.:|:|.|::.|.||.::|:|:|.||.|||:|||||:|.|.||:|..:| |||
Zfish   631 YGMVAAWLTELEIPKTETNFEERLILKAFVLKFMNAYAPIFYVAFFKGRFAGRPGDYVYVFHDYR 695

  Fly   729 QEECSSGGCLTELCIQLAIIMVGKQAF-NTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDK--- 789
            .|||:.||||.||||||:|||:|||.. |.:.|:.:|.           |.:|.....:.|:
Zfish   696 MEECAPGGCLIELCIQLSIIMLGKQLIQNNVFEIGIPK-----------LKKLCRTLKDKDREPK 749

  Fly   790 ------AKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLD 848
                  .:.::|..|:.|..:.  ||.|||:||::|:|||::|||:|||||.||||||::|:|||
Zfish   750 EIVEQPGRRQQWHMDYDLEPFD--GLTPEYMEMIIQFGFVSLFVASFPLAPLFALLNNVIEIRLD 812

  Fly   849 AKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDG 913
            |||.:|..:||.:.|.:|||:||.||..:||.|||.|.|:|:||||.||||||::..::.||:.|
Zfish   813 AKKFVTELRRPDAVRTKDIGIWYNILSGLGKFSVIINAFVISFTSDFIPRLVYQYMYSETGTMHG 877

  Fly   914 YLNFTLSEFKVID-SP-TLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVV 976
            ::|.|||.|.|.: .| |:.|    .|:||.|||.|:|.||.|.|.|..|..::.:||.|||||:
Zfish   878 FINHTLSYFNVSNFKPGTMPS----TSDITVCRYKDYREPPWSNEPYQFSKQYWSVLAARLGFVI 938

  Fly   977 VFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQ 1041
            :|:|.|.::.:||.|.||||...:.:|::::..:..::.:::|         |....::|:...:
Zfish   939 LFQNLVIIMSMLVAWLIPDMPKNISEQLKKDKTLLVDVFLNEE---------KEKLQLIQSLFSK 994

  Fly  1042 DM 1043
            |:
Zfish   995 DL 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	84/305 (28%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	266/629 (42%)
ano2b	NP_001314787.1	Anoct_dimer	94..363	CDD:292796	84/305 (28%)
ano2b	NP_001314787.1	Anoctamin	366..968	CDD:282414	266/628 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	611	1.000	Inparanoid score	I883
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm6575
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980