Protein Alignment subdued and ano2a

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_009291707.1
• Gene: ano2a / 563500
• ZFINID: ZDB-GENE-091204-400
• Length: 1368
• Species: Danio rerio
• Alignment Length: 1093
• Identity: 364/1093 - (33%)
• Similarity: 560/1093 - (51%)
• Gaps: 184/1093 - (16%)

  Fly    95 SASRESLGAADK-RARFAESNAPTLQLPE----SAEPRANGKRPTGNRTNPSNPAAPLLPMTDPD 154
            ||:....||.:: |.....|::.::|..:    :.:....|:|.|.:..:.:|..|.......|
Zfish     8 SATENWNGAPERMRVSAVRSDSSSMQSEKLRGVARDISELGQRGTASSGHDANDIAEDTEEPGP- 71

  Fly   155 FVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAY---RINAH----------- 205
               |..||                      |.|.|..|.:|:||.|   :..||
Zfish    72 ---GPGGG----------------------LCFADGHRRVDYVLVYHCKKRQAHHRHSVVSNGNV 111

  Fly   206 ---------------------------EPTELENTEKRRVFEANLISQGLEVESSQKDQ-IWFVK 242
                                       ||.:....:.|..||..|..:|||:|..::.: :.|.:
Zfish   112 PSQSPTPSLRSTKGNISEAVLEAGLGTEPADGLKDKIREEFERGLQEEGLEIEQDKEMRTVRFTR 176

  Fly   243 IHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSL 307
            :|.|..||.|.||:||||:|.|::                 :.|..|...|.|::    |.:..:
Zfish   177 LHVPWSVLSREAELLKLRVPTKKT-----------------YQLKEKTGLMGVMS----SFWMKI 220

  Fly   308 KHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIR-QDCFFTTAVRSRIVEFILDRQRFP 371
            ...||     ..|.|...| |....:..:||||.:|.||: ::..|:.|:|.|||..||.|   .
Zfish   221 NQPFQ-----PGVPEPQNP-RTRVLSQPFSRDKLHLLDIKSENSLFSNAIRGRIVYEILRR---T 276

  Fly   372 AKNQHDMAFGIERLIAEGVYSAAYPLHDG-----EITETGTMRALLYKHWASVPKWYRYQPLDDI 431
            |..|.....||..|:|:|||.:|:|||||     |..|....|.:|::.||:...:|:|||:|.|
Zfish   277 ACTQSCQTMGISSLLAKGVYDSAFPLHDGDFDSSEDKEHRNDRQMLHEEWANYGAFYKYQPMDLI 341

  Fly   432 KEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCD- 495
            ::|||.||||||||||.||.:|:.||.:||..|||...::...||.:::|.. ..|.|||||||
Zfish   342 RKYFGEKIGLYFAWLGVYTQLLIPASALGVAVFLYGCLTVDTNVPSQEMCDE-RLNFTMCPLCDR 405

  Fly   496 WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEH 560
            .|::|.|...|:.|:.:||.||.:||.||:|||.||.:|||.|||....:.|.|||||.:..||.
Zfish   406 VCDYWQLSSICSTARASYLFDNHATVGFAIFMSLWAAVFLEHWKRRQRCLQHSWDLTGMEDDEER 470

  Fly   561 P----RPQY--------------------------------LARLEHIPPTRVDYVTNIKEPTVP 589
            .    ||.|                                |......||...:.::
Zfish   471 AENELRPAYEDFLHKKQEKKAKNKKKEEPDAGTDDKGREKLLCAKGGQPPLASESLS-------- 527

  Fly   590 FWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVN 654
             |..:||....:.|.:||::.:.|.|:..|::||:.:.|.:.:.......::..|:.|.:|..:|
Zfish   528 -WTDRLPGFCINISSILLMVGVTFSAVSGVILYRIIVSAVMSMNPDHEAKANVRVIVTTTAVIIN 591

  Fly   655 LCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPG 719
            |.::.:|:.:|..:|.::||||:.:|:..|::.:.||.:||:.:|.:|.:||:|||||:|.|.||
Zfish   592 LLVVLVLDEIYGAIAAWITELEIPKTEATFEEHVILKAFLLKSMNAFAPVFYVAFFKGRFAGRPG 656

  Fly   720 EYNKLF-DYRQEECSSGGCLTELCIQLAIIMVGKQAF-NTILEVYLPMFWRKVLAIQVGLSRLFN 782
            :|..:| |:|.||||.||||.|:||||.|||:|||.. |.:.|:.:|...:.....:.......:
Zfish   657 DYVYVFKDFRMEECSPGGCLIEVCIQLGIIMLGKQLIQNNVFEIAIPKLKKMYRTYKEEKDGSAD 721

  Fly   783 NTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRL 847
            ......|.:.:||..|:.|..:  .||.|||:|||:||||||:|||:|||||.||||||::|:||
Zfish   722 EDDKDSKREPQRWDLDYDLEPY--EGLSPEYMEMVIQYGFVTLFVASFPLAPVFALLNNVIEIRL 784

  Fly   848 DAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLD 912
            ||.|.:|..:||.:...::||:||.||..|.|.:||||.|:|:|||:.|||:||::..::.||:.
Zfish   785 DAAKFVTEIRRPDAVSAKEIGIWYNILSGISKFAVITNAFVISFTSEFIPRMVYQYLYSETGTMH 849

  Fly   913 GYLNFTL-----SEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRL 972
            |:.|.||     |.||...:|  :....| .::..|||.|:|.||.|||.|.||..::.:||.||
Zfish   850 GFTNHTLAYFNTSNFKPGTAP--HDTDFD-RHLRICRYKDYRDPPWSPESYQLSKQYWSVLAARL 911

  Fly   973 GFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQT 1037
            .||:.|:|....:.:||.|.|||:...|::|::||..:..::::.:||.:    :..:|.|:  |
Zfish   912 AFVIFFQNLAMFLSMLVAWLIPDVPRSLKEQLKREKTLLMDLLLTEEADK----QCSQSHSL--T 970

  Fly  1038 PVDQDMDAASIQEPNAKFINI----------EKLLTENLTQIEMDAIIHGENP 1080
            ..:.|:....::|...:.:.:          |:|....||:.|.:..:..::|
Zfish   971 ATNTDVVIKGLEEGPPEELPVCSRMMLSQSDEELKELRLTKEEEEEELEEQSP 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	84/289 (29%)
		Anoctamin	431..1007	CDD:461349	246/619 (40%)
ano2a	XP_009291707.1	Anoct_dimer	78..337	CDD:465044	83/288 (29%)
		Anoctamin	341..946	CDD:461349	246/619 (40%)
		PHA03247	<1021..1342	CDD:223021	1/3 (33%)