DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano8a

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_002660858.1	Gene:	ano8a / 562947	ZFINID:	ZDB-GENE-070912-583	Length:	1008	Species:	Danio rerio

Alignment Length:	1008	Identity:	236/1008 - (23%)
Similarity:	363/1008 - (36%)	Gaps:	383/1008 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 YLTNK----IPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVD-----EEIFPKRA--HRF---TAI 335
            :|.|:    ||.:.:..|..|     ..|.:.||:.:.:.:     |::..::|  .||   |..
Zfish    53 WLLNQIRLGIPQIRIQIRQHK-----YTHTYAFFITSSFENLLRGAEQMGMQKAVKQRFGGGTRR 112

  Fly   336 YSRDKEYLFD-IRQD-CFFTTAVRSRIVEFILDRQRFPAKN---QHDMAF--G---IERLIAEGV 390
            :|.:::.::: |..: ||||:..|..|:::.||..|  ||.   .|::.|  |   |..|||..|
Zfish   113 FSCEEDDIYENIESELCFFTSQERQGIIKYWLDNLR--AKQGEALHNIHFLEGQPIIPELIARRV 175

  Fly   391 YSAAYPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLL 455
            ....:|||:..|...      |...|  |......|||||:.:||||||.:||||||:||..:|.
Zfish   176 ILQMFPLHEQRILNQ------LMTSW--VQAVCERQPLDDVCDYFGVKIAMYFAWLGFYTNSMLY 232

  Fly   456 ASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPST 520
            .:::|.:.::::              :|..|:..:|              |
Zfish   233 PAVIGFLLWMFA--------------ESDQTSQDIC--------------C-------------- 255

  Fly   521 VFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHE-EHPRPQYLARLEHIPPTRVDYVTNIK 584
            |.||:|...|||||||.|||..||:.::|......... |.||||:.....|.|      ||..:
Zfish   256 VVFAIFNVVWATLFLERWKRREAELAYKWGTLDTPAESLEEPRPQFRGVKRHSP------VTGCE 314

  Fly   585 EPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSS-------- 641
            |...|.|:.::.....||.:.:|  .|.||.|        :|...|::....|.|..
Zfish   315 EFYYPPWKRRMFRWFVSFPICIL--CLCFVCL--------AMFICLELQEFVMETKEFPSICRFI 369

  Fly   642 -AIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIF 705
             .|:||..    |.:|     :.:|..:|.:|.::|.:|.|:.:|::|.||....||:|.|.|:|
Zfish   370 PKILLAVT----VTVC-----DEVYKKIALWLNDMENYRLQSTYDNNLILKTVFFQFINSYLSLF 425

  Fly   706 YIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFW--- 767
            ||.|:             |.|..:        |.|:   ||.:::.:|....|.||..|..:
Zfish   426 YIGFY-------------LKDMER--------LKEM---LATLLIFRQFLQNIKEVLQPYLYEHH 466

  Fly   768 -------------------------RKVLAIQVGLSRLFNNTPNPDKAKDERW------------ 795
                                     |..|..|..|....|.||.....|.||.
Zfish   467 KLGALRTLWDLIQTMLLNYSHLIVQRIRLTCQASLDMNKNGTPPEQSEKRERRSLISSYRVPKTE 531

  Fly   796 ------------------------------------------------------MRD-------- 798
                                                                  :||
Zfish   532 EVDDDAGLKHRKVSFTEKVEYKDKAVEEPTQGSPQDDDSPTLVEEGMDPSLIFDIRDDEDDDEDD 596

  Fly   799 --------------------------FKLLDW-------GARGLF-PE--------------YLE 815
                                      .|...|       |:..|. ||              |.|
Zfish   597 DREIDDSASKSQRRKGKAAGGENNTMEKKKSWMDPPEETGSTVLTQPEIESCMLIYEDTLHDYQE 661

  Fly   816 MVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKL 880
            |.:|:|:|.:|.:|||||...||:|||:|:|.||.||.:..:||..|||.:||.|...::.:|.:
Zfish   662 MFIQFGYVVLFSSAFPLAAMCALINNIVEIRSDALKLCSGLQRPFGQRVENIGQWQTAMEAMGLI 726

  Fly   881 SVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRY 945
            ::|.|.::|                                          ...|.|..:
Zfish   727 AIIVNCYLI------------------------------------------GQCGQLQRL----- 744

  Fly   946 TDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQI------ 1004
                .|..|||...:|             |||.|:|..|:..::...|||:...:.|::
Zfish   745 ----FPWLSPEMAIVS-------------VVVLEHFAILLKYVIHVAIPDVPNWVADEMAKLEYQ 792

  Fly  1005 RREVYVTNEIIIDQEAHRAR------FERAKRSSSVLQTPVDQ---DMDAASIQ----EPNAKFI 1056
            |||....:|.:..|...:.|      .|..|.:..:.:...||   |:....:|    .|.|||.
Zfish   793 RREALKKHERLAQQHQQQKRRKTEQDEEHQKLAEELARQQSDQDKSDVGGGEVQHHEKSPGAKFS 857

  Fly  1057 NI-EKL-----LTENLTQIEMDAIIHGENPITG 1083
            :. :||     |..|...:::..||    |:.|
Zfish   858 STGDKLKRPSSLLGNNNVMKLKQII----PLQG 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	43/166 (26%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	166/741 (22%)
ano8a	XP_002660858.1	Anoctamin	208..>446	CDD:282414	90/328 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920