Protein Alignment subdued and ano8a

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_002660858.1
• Gene: ano8a / 562947
• ZFINID: ZDB-GENE-070912-583
• Length: 1008
• Species: Danio rerio
• Alignment Length: 1008
• Identity: 236/1008 - (23%)
• Similarity: 363/1008 - (36%)
• Gaps: 383/1008 - (37%)

  Fly   285 YLTNK----IPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVD-----EEIFPKRA--HRF---TAI 335
            :|.|:    ||.:.:..|..|     ..|.:.||:.:.:.:     |::..::|  .||   |..
Zfish    53 WLLNQIRLGIPQIRIQIRQHK-----YTHTYAFFITSSFENLLRGAEQMGMQKAVKQRFGGGTRR 112

  Fly   336 YSRDKEYLFD-IRQD-CFFTTAVRSRIVEFILDRQRFPAKN---QHDMAF--G---IERLIAEGV 390
            :|.:::.::: |..: ||||:..|..|:::.||..|  ||.   .|::.|  |   |..|||..|
Zfish   113 FSCEEDDIYENIESELCFFTSQERQGIIKYWLDNLR--AKQGEALHNIHFLEGQPIIPELIARRV 175

  Fly   391 YSAAYPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLL 455
            ....:|||:..|...      |...|  |......|||||:.:||||||.:||||||:||..:|.
Zfish   176 ILQMFPLHEQRILNQ------LMTSW--VQAVCERQPLDDVCDYFGVKIAMYFAWLGFYTNSMLY 232

  Fly   456 ASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPST 520
            .:::|.:.::::              :|..|:..:|              |
Zfish   233 PAVIGFLLWMFA--------------ESDQTSQDIC--------------C-------------- 255

  Fly   521 VFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHE-EHPRPQYLARLEHIPPTRVDYVTNIK 584
            |.||:|...|||||||.|||..||:.::|......... |.||||:.....|.|      ||..:
Zfish   256 VVFAIFNVVWATLFLERWKRREAELAYKWGTLDTPAESLEEPRPQFRGVKRHSP------VTGCE 314

  Fly   585 EPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSS-------- 641
            |...|.|:.::.....||.:.:|  .|.||.|        :|...|::....|.|..
Zfish   315 EFYYPPWKRRMFRWFVSFPICIL--CLCFVCL--------AMFICLELQEFVMETKEFPSICRFI 369

  Fly   642 -AIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIF 705
             .|:||..    |.:|     :.:|..:|.:|.::|.:|.|:.:|::|.||....||:|.|.|:|
Zfish   370 PKILLAVT----VTVC-----DEVYKKIALWLNDMENYRLQSTYDNNLILKTVFFQFINSYLSLF 425

  Fly   706 YIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFW--- 767
            ||.|:             |.|..:        |.|:   ||.:::.:|....|.||..|..:
Zfish   426 YIGFY-------------LKDMER--------LKEM---LATLLIFRQFLQNIKEVLQPYLYEHH 466

  Fly   768 -------------------------RKVLAIQVGLSRLFNNTPNPDKAKDERW------------ 795
                                     |..|..|..|....|.||.....|.||.
Zfish   467 KLGALRTLWDLIQTMLLNYSHLIVQRIRLTCQASLDMNKNGTPPEQSEKRERRSLISSYRVPKTE 531

  Fly   796 ------------------------------------------------------MRD-------- 798
                                                                  :||
Zfish   532 EVDDDAGLKHRKVSFTEKVEYKDKAVEEPTQGSPQDDDSPTLVEEGMDPSLIFDIRDDEDDDEDD 596

  Fly   799 --------------------------FKLLDW-------GARGLF-PE--------------YLE 815
                                      .|...|       |:..|. ||              |.|
Zfish   597 DREIDDSASKSQRRKGKAAGGENNTMEKKKSWMDPPEETGSTVLTQPEIESCMLIYEDTLHDYQE 661

  Fly   816 MVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKL 880
            |.:|:|:|.:|.:|||||...||:|||:|:|.||.||.:..:||..|||.:||.|...::.:|.:
Zfish   662 MFIQFGYVVLFSSAFPLAAMCALINNIVEIRSDALKLCSGLQRPFGQRVENIGQWQTAMEAMGLI 726

  Fly   881 SVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRY 945
            ::|.|.::|                                          ...|.|..:
Zfish   727 AIIVNCYLI------------------------------------------GQCGQLQRL----- 744

  Fly   946 TDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQI------ 1004
                .|..|||...:|             |||.|:|..|:..::...|||:...:.|::
Zfish   745 ----FPWLSPEMAIVS-------------VVVLEHFAILLKYVIHVAIPDVPNWVADEMAKLEYQ 792

  Fly  1005 RREVYVTNEIIIDQEAHRAR------FERAKRSSSVLQTPVDQ---DMDAASIQ----EPNAKFI 1056
            |||....:|.:..|...:.|      .|..|.:..:.:...||   |:....:|    .|.|||.
Zfish   793 RREALKKHERLAQQHQQQKRRKTEQDEEHQKLAEELARQQSDQDKSDVGGGEVQHHEKSPGAKFS 857

  Fly  1057 NI-EKL-----LTENLTQIEMDAIIHGENPITG 1083
            :. :||     |..|...:::..||    |:.|
Zfish   858 STGDKLKRPSSLLGNNNVMKLKQII----PLQG 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	43/166 (26%)
		Anoctamin	431..1007	CDD:461349	166/741 (22%)
ano8a	XP_002660858.1	Anoctamin	208..788	CDD:461349	165/734 (22%)