Protein Alignment subdued and ano8b

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_691248.6
• Gene: ano8b / 562782
• ZFINID: ZDB-GENE-121024-1
• Length: 1110
• Species: Danio rerio
• Alignment Length: 991
• Identity: 222/991 - (22%)
• Similarity: 349/991 - (35%)
• Gaps: 363/991 - (36%)

  Fly   278 RLRNAAHYLTNKIPGMSVVNRSTKSVFSSL-----KHVFQFFLRNIY--VDEEIFPKRAHRFTAI 335
            ||..|..::.:....|..|......|..:.     .|...:.|.:|.  :.|.|...|.|:.|.:
Zfish    63 RLLQAGRHIMSHKSWMKTVPTENCDVLMTFPDTTDDHTLLWLLNHIRLGIPELIIQIRHHKHTRM 127

  Fly   336 Y-----------------------------------SRDKEYLFD-IRQD-CFFTTAVRSRIVEF 363
            |                                   |.:::|::: |..: ||||:..|..|:::
Zfish   128 YAFFVTATYENLLRGAEEMGLQKAVKPEFGGGSRSFSCEEDYIYENIESELCFFTSQERQSIIKY 192

  Fly   364 ILDRQRFPAKN---QHDMAF--G---IERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVP 420
            .||..|  ||:   .|::.|  |   |..|.|.||....:|||:..|.      ..|.|.|  |.
Zfish   193 WLDNLR--AKHGEALHNIHFLEGQPIIPELRARGVIQQVFPLHEQRIL------GQLMKSW--VQ 247

  Fly   421 KWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGN 485
            .....||||||.:||||||.:||||||:||..:|..:::|.:.    |...::....:|||
Zfish   248 AVCEKQPLDDICDYFGVKIAMYFAWLGFYTTSMLYPAVIGFVL----WMLTESDQTSRDIC---- 304

  Fly   486 TNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWD 550
                                |              |.||:|...|||||||.|||..||:.::|.
Zfish   305 --------------------C--------------VVFALFNVVWATLFLERWKRRGAELAYKWG 335

  Fly   551 LTGFDVHE-EHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFV 614
            ........ |.||||:..      ..|...||..:|...|.||.::...:.||.|.:|.:...|:
Zfish   336 TLNTPAESLEEPRPQFRG------VKRCSPVTGCEEFYYPPWRRRVFRWLVSFPVCILCLCFVFL 394

  Fly   615 ALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWR 679
            |:|  |.:.   |....:|...:...:..:.....|..|..|     :.:|..:|.:|.::|.:|
Zfish   395 AML--VCFE---LQEFVMGIKELPRVARFIPKIMLAITVTAC-----DEVYRKIACWLNDMENYR 449

  Fly   680 TQTQFDDSLTLKIYLLQFVNYYASIFYIAFF---------------------------------- 710
            .|:.::.:|.:|:.|.||||.|.|:|||.|:
Zfish   450 LQSAYEKNLIIKMVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLIIRQFVQNMKEVLQPYLAE 514

  Fly   711 ---------------------------------------------KGKFVGHPGEYNKLFDYRQE 730
                                                         :|..:|..|..    |.|:.
Zfish   515 RHRLGELTLRAVWELLVSALLKYGRLAAGRAQVSPSDPTVLGPGLRGPQMGEEGHQ----DRRER 575

  Fly   731 ECSSGGC--------------------LTELCIQLAIIMVGKQAF----------------NTIL 759
            :|.:|||                    .:|..|... :.:.|.:|                ::.|
Zfish   576 KCLNGGCGVPDEDMEEEHGERHSEEENESESLIDCG-LKLRKVSFIEKVERKSASCVSPVDDSFL 639

  Fly   760 EVYLP-MFWR----------------------KVLAIQ-----------VGLSRLFNNTPNPD-K 789
            |...| |..|                      |.||.:           |.|.:...:....| |
Zfish   640 EEGSPTMVERGMDPASVFEMCDDEDENGAPEMKELAAEPLPTGVENSSSVKLRKRGRSLERADSK 704

  Fly   790 AKDERWM-----RDFKLLDWGA--------RGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNN 841
            .|.:.||     ::...|....        :..|.:|.||.:|:|:|.:|.:|||||...||:||
Zfish   705 TKRDSWMDPPEEQETNTLTQAEVEGCMQTYQDTFQDYQEMFVQFGYVVLFSSAFPLAAMCALINN 769

  Fly   842 ILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVN 906
            |:|:|.||.||.|..:||...||..||.|..:::.:|.:::|.|.::|
Zfish   770 IIEIRSDAFKLCTSLQRPFGLRVASIGQWQTVMEAMGLIAIIVNCYLI----------------- 817

  Fly   907 KQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACR 971
                                     ...|.|..:         .|..|||...:|
Zfish   818 -------------------------GQCGQLQRL---------FPWLSPEMAIIS---------- 838

  Fly   972 LGFVVVFENFVALVMILVRWCIPDMSVELRDQI------RREVYVTNE----IIIDQEAHRARFE 1026
               :|:.|:|..|:..::...|||:...:.:::      |:|.:..:|    ....|:..|.|.|
Zfish   839 ---IVILEHFAVLLKYIIHVAIPDIPSWVGEEMAKLEFQRKEAFKKHERQAQQHFQQQQRRKREE 900

  Fly  1027 RAKRSSSVLQTPVDQD 1042
            ..::..:..|...|:|
Zfish   901 EERQRQAEYQARRDRD 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	46/201 (23%)
		Anoctamin	431..1007	CDD:461349	163/745 (22%)
ano8b	XP_691248.6	Anoctamin	258..870	CDD:461349	162/738 (22%)