DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano5b

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_005168948.1	Gene:	ano5b / 560102	ZFINID:	ZDB-GENE-061215-108	Length:	930	Species:	Danio rerio

Alignment Length:	951	Identity:	351/951 - (36%)
Similarity:	535/951 - (56%)	Gaps:	126/951 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GNVGGV--YDDRECSCP--REFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRV 218
            ||.|.:  ..||....|  ||..:..:...|:||:|.||.|||||:| ::..|..  :..|:||.
Zfish    41 GNNGSINSISDRGIQLPGHREIDKFDQNRDSVFFKDGVRRIDFVLSY-VDDKEGD--KKAERRRE 102

  Fly   219 FEANLISQGLEVESSQKDQ-----IWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNR 278
            |||||...|||:|:..|.:     ..::|||||.|||..||::||:::|.|
Zfish   103 FEANLEKAGLELETEDKSESDDRKTHYLKIHAPWEVLATYADVLKIKVPFK-------------- 153

  Fly   279 LRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYL 343
                          :|.:.::.:.....|.|.|:       :.|.|.......|||.:.:.|...
Zfish   154 --------------VSDIPKAREVPLEWLSHPFR-------LPENIMRPEPDYFTAPFDKSKVDF 197

  Fly   344 FDI-RQDCFFTTAVRSRIVEFILDRQRFPAKNQHDM-AFGIERLIAEGVYSAAYPLHD------G 400
            |.| .:|.||..:.|:|||.:||.|..:..:::.:. ..||.||:..|.|::||||||      .
Zfish   198 FLIDDKDTFFPPSTRNRIVYYILTRCPYYKEDRKEKDKTGINRLLNNGTYTSAYPLHDCRYWKKA 262

  Fly   401 EITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFL 465
            :..:..:.|..||::||....:|:.|||:.||:|:|.|||:||||||:||.||..|:::|||||:
Zfish   263 QDMQCESERYHLYRYWARFLCFYKEQPLNLIKKYYGEKIGIYFAWLGFYTEMLFYAAVMGVICFV 327

  Fly   466 YSWFSLKNYVPVKDIC--QSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFM 527
            |...|.::.:..|:||  :.|.. |.|||||| .|::|.|..||..:..::|.||..|||||:||
Zfish   328 YGVLSYEDNITSKEICDPKIGGM-IVMCPLCDKKCSYWKLNSTCLSSWQSHLFDNEGTVFFAMFM 391

  Fly   528 SFWATLFLELWKRYSAEITHRWDLTGFDVHEE--HPRPQYLARLEHIPPTRVDYVTNIKEPTVPF 590
            ..|.|||||.|||..|.:.:.|||..|:..::  ..||:|   .:.....|::.:|...||.:||
Zfish   392 GIWVTLFLEFWKRRQARLEYEWDLVDFEEEQQQLQIRPEY---EQKCTGRRLNRITQEMEPYLPF 453

  Fly   591 WRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSS--------AIV--- 644
             ..|......|.:.||....|....::.|:.||:::.||.   ||.|..||        :::
Zfish   454 -PSKCARFCLSGATVLFWTCLIVACIMGVIAYRLAVYAAF---ASVMKDSSTSKIQLVGSLITPQ 514

  Fly   645 LATA-SAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIA 708
            |||: :|:.:|..::.|||::|.|:|.::|::|:.:|..::::.||:|:::.||||||:|.||:|
Zfish   515 LATSVTASCINFVIILILNFLYEHVAIWITDMEIPKTHLEYENKLTMKMFMFQFVNYYSSCFYVA 579

  Fly   709 FFKGKFVGHPGEYNKLF----DYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPM---F 766
            ||||||||:||.|:.:|    ..|.|||:.||||.||..||.|:|.|||....:.|..||:   :
Zfish   580 FFKGKFVGYPGNYSYMFGKWSTLRNEECAPGGCLIELTTQLLIVMAGKQMVGNVQEALLPLVRNW 644

  Fly   767 WRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFP 831
            |.         ||...:.|   ::...||.:|..|.::...|||.||||||:|:||:|:|||:||
Zfish   645 WS---------SRKGRSHP---ESTYSRWEQDHDLQNFSQFGLFYEYLEMVIQFGFITLFVASFP 697

  Fly   832 LAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMI 896
            |||..||.|||||:|:||.|..|..:||::.:.|:||.|..||:.:..:||:||.||:|||||||
Zfish   698 LAPLLALFNNILEVRVDAWKFTTQFRRPMAAKARNIGAWEEILNVVAIMSVVTNAFIMAFTSDMI 762

  Fly   897 PRLV--YRHYVNKQGTLDGYLNFTLSEFKVI-----------DSPTLYSLAGDLSNITTCRYTDF 948
            ||||  |.::...:..:.||:..:||.:.:.           ::|:.:    :.|.||||||.|:
Zfish   763 PRLVYLYAYHPGIEANMTGYITNSLSIYNISQIPEDNLPEAGENPSWF----NSSTITTCRYRDY 823

  Fly   949 RLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNE 1013
            |.||....:||.:..|:.|||.:|.|:::.|:.|.:|...|.|.|||:..|::.:|:||.::..|
Zfish   824 RYPPGHLRQYTHTMQFWHILAAKLAFIIIMEHVVFVVKFFVAWLIPDVPSEVKARIKRERFLVQE 888

  Fly  1014 IIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASI--QEPN 1052
            .:.:.|..:.:.:.::  |..|.|      :.||:  ..||
Zfish   889 YLHNYEVEKLKMQLSQ--SFCLST------ETASLLPSSPN 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	80/254 (31%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	249/612 (41%)
ano5b	XP_005168948.1	Anoct_dimer	73..290	CDD:292796	80/254 (31%)
ano5b	XP_005168948.1	Anoctamin	293..883	CDD:282414	250/613 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.790