DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano7

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_009289708.1	Gene:	ano7 / 556876	ZFINID:	ZDB-GENE-130530-576	Length:	883	Species:	Danio rerio

Alignment Length:	946	Identity:	345/946 - (36%)
Similarity:	520/946 - (54%)	Gaps:	119/946 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 AAPLLPMTD-PDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYR-----I 202
            :|.|:.::| |:...|::      .:|:.|:|       |.:: |.|.|.:|||||.:.     :
Zfish    12 SATLIALSDHPEQTYGSI------EKCAKPQE-------NKNV-FSDGVTTIDFVLVWEESGSPL 62

  Fly   203 NAHEPTELENTEKRRV-------FEANLISQGLEVESSQ----KDQIWFVKIHAPLEVLRRYAEI 256
            .:.:..||..:..|..       |.:.|...||..|..:    |.:..:|.:.||..||..|||.
Zfish    63 KSADGDELSFSSSRDTHRKWRTEFLSKLQEAGLHQEMKEVVQGKTKTTYVLLSAPWNVLCYYAEE 127

  Fly   257 LKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVD 321
            :.||:|::  :....||..|..:....|     ||.:...:                 :.|...|
Zfish   128 ISLRVPLQ--VVTTPISNWSETILEKLH-----IPNIMAQD-----------------VPNYPPD 168

  Fly   322 EEIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLI 386
            ....|.|..:.       :.:|....:|.||.|..|.:|:..||.|..:.|..:.::  ||.||:
Zfish   169 YYTCPFRTTKL-------ERFLGHENKDTFFKTTQRHQILYEILARTPYGALKRGEV--GIGRLV 224

  Fly   387 AEGVYSAAYPLHDG--------EITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYF 443
            :|.|.:||:|||:|        |..:...||.:|:.:||....|.:|||||.|:||||.||.|||
Zfish   225 SEKVLTAAFPLHEGPFQLPKTQEDPQCLNMRQILHHYWARWACWRKYQPLDHIREYFGEKIALYF 289

  Fly   444 AWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNY 508
            ||||:||..||.|::||.|.||:..:.:...||.:::|.|||..| |||||:.|:.|:|...|..
Zfish   290 AWLGFYTGWLLPAAVVGFIIFLFGIWLMVTDVPAEELCSSGNAFI-MCPLCNICSHWNLSSICYT 353

  Fly   509 AKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIP 573
            .|...|.||..||||::|||.||..|||.|||.|:.::||||.:.|:..||.|||::.|.   .|
Zfish   354 YKAGLLFDNGGTVFFSIFMSLWAVTFLEYWKRTSSILSHRWDCSEFEEIEERPRPEFTAL---AP 415

  Fly   574 PTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMT 638
            .|..:.||..:||..|..| :|..|:....|::|:|::..:.|:|:::||..:...:....|...
Zfish   416 MTVRNPVTGAEEPYFPEAR-RLSRTLTGNMVIILMISIVLIFLMAIILYRTILSIIIYRSQSAFF 479

  Fly   639 TSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYAS 703
            ..||..:|:.:.:.:||.::.:|:.:|.:||:.||..||.||||:::::..||:::.||||:|:|
Zfish   480 IFSAGRIASLTGSMLNLLVILLLSRLYTYLAQCLTRWEMHRTQTEYENAFILKVFIFQFVNFYSS 544

  Fly   704 IFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLP---M 765
            ..|||||||:|||:||.||.|...|.|:|.:.|||.||..:|.:||||||..:.|.|..||   .
Zfish   545 PVYIAFFKGRFVGYPGSYNTLLGIRNEDCGASGCLIELAQELLVIMVGKQVISNIQEFVLPKLKT 609

  Fly   766 FWRKVLAIQVGLSRLFNNTPNPD-KAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAA 829
            :|.|   .::..:|.......|| .::...|..|::||  ...|||.||||||||:||:||||||
Zfish   610 WWHK---RKLKPARSQEVIDEPDTNSQINPWENDYQLL--VCEGLFDEYLEMVLQFGFITIFVAA 669

  Fly   830 FPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSD 894
            .||||.|||:||.:|:||||:|.:..::|||.:|.:|||:|..||..|..|:||:|.|:||||||
Zfish   670 CPLAPLFALINNWVEVRLDAQKFVCEYRRPVVERAQDIGIWLTILQFISYLAVISNAFLIAFTSD 734

  Fly   895 MIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYT 959
            .:|||.||:   ..|::.||:|||||.     :|..::     .|..:|||...|     .||..
Zfish   735 FLPRLFYRY---TAGSMSGYINFTLSV-----APANFT-----QNEMSCRYRGLR-----DEKGQ 781

  Fly   960 LSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIID------- 1017
            .:..:|.:||.||.||::||:.|.|:..::.|.:||:..|:..:|:||.|:..|.:.:
Zfish   782 NTQDYYHLLAIRLSFVIIFEHVVLLIGRIIDWIVPDIPEEVEIKIKREHYMAKEALAENQSLSKS 846

  Fly  1018 --QEAHRARFERAKR------SSSVLQTPVDQDMDA 1045
              :|..|..||..:|      ::::..|..|:.|.|
Zfish   847 VLEEMGRQNFELRQRIRTQSPTNNMSPTSEDEAMPA 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	70/265 (26%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	250/579 (43%)
ano7	XP_009289708.1	Anoct_dimer	42..274	CDD:292796	70/264 (27%)
ano7	XP_009289708.1	Anoctamin	277..830	CDD:282414	251/580 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920