DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano3

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_021326430.1	Gene:	ano3 / 553392	ZFINID:	ZDB-GENE-111031-3	Length:	1026	Species:	Danio rerio

Alignment Length:	1053	Identity:	378/1053 - (35%)
Similarity:	545/1053 - (51%)	Gaps:	172/1053 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RGRDTS-QRFLDQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNP 143
            :|..|| ...|.::.|.:||.||....:.....|:....|.:|.|..|:        :.|:.|:.
Zfish    33 KGMHTSISEILKEKTLKSSRRSLPCLAQSQTHPENLNHFLSVPLSPGPK--------SYTHSSSV 89

  Fly   144 AAPLLPMTDPDFVKGNVGGVY-DDRECS-----------CPREFYQRGEIN-------------- 182
            :|....:|.|....|.  .|| ::||..           ..::...||::.
Zfish    90 SASCTHITPPATDTGQ--DVYTEERETGGFEPKTDETLLVQQKPVSRGKLEARTDSVKGKNLETP 152

  Fly   183 TSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVE---SSQKDQIWFVKIH 244
            :.|.|.|..:.||::|.|:.::.:      .|||..||.||.::||.:|   |.....|.|||||
Zfish   153 SGLMFRDGKKRIDYILVYKKSSPQ------VEKRCTFERNLRAEGLMLEKEPSLTNSDIMFVKIH 211

  Fly   245 APLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTN---KIPGMSVVNRSTKSVFSS 306
            ||.:.|.:|||.:.:|||.::. |                |.|:   |..|.....|     |..
Zfish   212 APWDTLCKYAEQMNIRMPFRKK-C----------------YFTDWKKKAMGSRFQLR-----FRQ 254

  Fly   307 LKHVFQFFLRN-IYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQDCFFTTAVRSRIVEFILDR 367
            ||   .:..|| :.:|:|..|.....  :||.:.|.:.:.|.| .::.||:.:.|||||..:|.|
Zfish   255 LK---SWLPRNPMKLDKEALPDLVETDCYTAPFCRARMHHFTINNRETFFSNSTRSRIVHHVLQR 316

  Fly   368 QRF---PAK--------------NQHDMAF---------GIERLIAEGVYSAAYPLHDG------ 400
            .::   .:|              .||:...         ||.||:....|.||:|.|:|
Zfish   317 TKYEDGKSKMAPPLCCLNLLYYYGQHERLLIGQSGSSWEGINRLLGNSTYEAAFPPHEGCYKSRH 381

  Fly   401 EITETGTM--RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVIC 463
            .|...|..  |.|||:.||....||:|||||.|:.|||.||||||||||:||.||:.|::||:..
Zfish   382 PIKTHGAQNHRHLLYERWARWGIWYKYQPLDLIRRYFGEKIGLYFAWLGWYTGMLIPAALVGLFV 446

  Fly   464 FLYSWFSLKNYVPVKDICQSGNTNITMCPLCDW-CNFWDLKETCNYAKVTYLIDNPSTVFFAVFM 527
            |||..|::.:....|:||::..|  .|||:|:. |:.|.|.::|.|||||:|.||..|||||:||
Zfish   447 FLYGLFTMDSSQVSKEICEANTT--VMCPMCEGNCSSWTLSDSCVYAKVTHLFDNGGTVFFAIFM 509

  Fly   528 SFWATLFLELWKRYSAEITHRWDLTGFDVHE---------EHPRPQYLARLEHIPPTRVDYVTNI 583
            :.|||:|||.|||..||:|:.|||..::..|         |..|||:.|:...  ..||:.::..
Zfish   510 AIWATVFLEFWKRRRAELTYDWDLIDWEEEECKPCVMVCSEELRPQFEAKYSR--KERVNPISGK 572

  Fly   584 KEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATA 648
            .||..|. ..||...:.|.|.:..:|:|...|:.||||:|:..:.............:.....:.
Zfish   573 PEPFQPL-TDKLSRLMVSVSGIFFMISLVLTAVFAVVVFRLIAMEKFVSFQWEFVKKNWQFATSG 636

  Fly   649 SAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGK 713
            :...:|..::..||.:|..:|..||.||..||::::::|..||::|.||||..:|.||||||.|:
Zfish   637 TGVCINFMIIMSLNVVYEKVAYLLTNLEHPRTESEWENSFALKMFLFQFVNLNSSTFYIAFFLGR 701

  Fly   714 FVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPM---FWRKVLAIQ 774
            |.|.||:|||||: :|.|||...|||.:||:|:.:|||.||.:|..:|:..|:   :|.:
Zfish   702 FAGRPGDYNKLFNRWRMEECHPSGCLIDLCLQMGVIMVLKQIWNNFMELGYPLLQNWWSR----- 761

  Fly   775 VGLSRLFNNTPNPDKAKDE--RWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFA 837
                |..........:|:|  :|.||:.|....|.||..||||||||:||.|||||||||||..|
Zfish   762 ----RKMKRAGEQSNSKEELPQWDRDWNLQPMNAHGLVDEYLEMVLQFGFTTIFVAAFPLAPLLA 822

  Fly   838 LLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLV-- 900
            |||||:|:||||.|.:|..:||:..|..|||:|:.:|:.||.::||||.|:||.|||.|||.|
Zfish   823 LLNNIIEIRLDAYKFVTQWRRPMPARATDIGIWHGVLEGIGVVAVITNAFVIAITSDYIPRFVYA 887

  Fly   901 ----------YRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNIT----TCRYTDFRLP 951
                      |||    :..|.||||.:||.|.:          |:|.|.:    .|||.|:|.|
Zfish   888 IKYGPCVDKGYRH----EKCLRGYLNNSLSVFDM----------GELRNGSYENQYCRYRDYRAP 938

  Fly   952 PSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIII 1016
            |.|||.|..:..|:.:||.||.|::|||:.|..:...:...||||..:|.|::|||.|:..|::.
Zfish   939 PWSPEPYEFTLQFWHVLAARLAFIIVFEHLVFGIKTFIAHMIPDMPKDLCDRMRREKYLMQEMVY 1003

  Fly  1017 DQEAHRARFERAK 1029
            :.|....:.||.|
Zfish  1004 EAELEHLQKERKK 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	85/285 (30%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	255/607 (42%)
ano3	XP_021326430.1	Anoct_dimer	163..411	CDD:318420	83/278 (30%)
ano3	XP_021326430.1	Anoctamin	414..994	CDD:309610	255/607 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm6575
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830