Protein Alignment subdued and ANO10

DIOPT Version :9

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_001333393.1
• Gene: ANO10 / 55129
• HGNCID: 25519
• Length: 699
• Species: Homo sapiens
• Alignment Length: 781
• Identity: 183/781 - (23%)
• Similarity: 312/781 - (39%)
• Gaps: 249/781 - (31%)

  Fly   344 FDIRQDCFFTTAVRSRIVEFIL------DRQRFPAKNQHDMAFG---IERLIAEGVYSAAYPLHD 399
            ||...|.|.|.|....|::..|      |.:..|...|..:..|   :.||:..|:....:||||
Human   111 FDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHD 175

  Fly   400 GE----ITETGTMRALLYKHWASVPKWY-----RYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLL 455
            .|    :.:|                ||     :|||:|.|:.|||..|.|||.:|.|:|:.|:.
Human   176 SEALKKLEDT----------------WYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIP 224

  Fly   456 ASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPST 520
            .:::|:..:|:.|.....|
Human   225 MAVIGLPYYLFVWEDYDKY---------------------------------------------- 243

  Fly   521 VFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKE 585
            |.||.|...|:|:.||||||..|.:|:||.........|.|||.:...|      .::.:|..:|
Human   244 VIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVL------GINSITGKEE 302

  Fly   586 PTVPFWRMKLPATVFSFSVVLLLIALAFVAL-LAVVVYRMSMLAALKVGASPMTTSS-----AIV 644
            |..|.::.:|.         :.|::|.||.| |...:|.|.:...::|.|..:..:|     :::
Human   303 PLYPSYKRQLR---------IYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVL 358

  Fly   645 LATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAF 709
            |...|..:.  .::.|:|.:|.:.||:||..|..|.::.:.:.|.||:.:..|:|.:||:|||||
Human   359 LYVPSIIYA--IVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAF 421

  Fly   710 FKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFW------- 767
            .....        ||.  ||              .||.:::..|..|.|:|.:|| :|
Human   422 VLKDM--------KLL--RQ--------------SLATLLITSQILNQIMESFLP-YWLQRKHGV 461

  Fly   768 ---RKVLAIQVGL-SRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVA 828
               |||.|::..: :.|:      ::...|:.|..:       .|.|.:|||:.||:|:|::|..
Human   462 RVKRKVQALKADIDATLY------EQVILEKEMGTY-------LGTFDDYLELFLQFGYVSLFSC 513

  Fly   829 AFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWY----------RILDC------I 877
            .:|||..||:|||..|:..||.|:....|||.|:...:||||.          |.|:|      :
Human   514 VYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQIIFCLDTGVKRGLNCKVMRNLL 578

  Fly   878 GKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITT 942
            |::.:....|::.    ::.:|.:.               |:|...|:.:..|..::..::.:
Human   579 GEMEMSCVLFVVV----VVSQLAFE---------------TMSVISVVTNCALIGMSPQVNAV-- 622

  Fly   943 CRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRRE 1007
                   .|.|..:         :||     .||..|:.:..:..::.:.|||....::.::.|.
Human   623 -------FPESKAD---------LIL-----IVVAVEHALLALKFILAFAIPDKPRHIQMKLARL 666

  Fly  1008 VYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASIQEPNAKFINIEKLLTENLTQIEMD 1072
            .:.:.|.:..|:.                                       ||:||||.:..|:
Human   667 EFESLEALKQQQM---------------------------------------KLVTENLKEEPME 692

  Fly  1073 A 1073
            :
Human   693 S 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	25/101 (25%)
		Anoctamin	431..1007	CDD:282414	146/608 (24%)
ANO10	NP_001333393.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920