DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ANO1

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_001365021.1	Gene:	ANO1 / 55107	HGNCID:	21625	Length:	1049	Species:	Homo sapiens

Alignment Length:	1077	Identity:	390/1077 - (36%)
Similarity:	557/1077 - (51%)	Gaps:	224/1077 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGV 163
            |:.||.|...  |....|:.|   :|..|.|.|..|             ||..|......|:..:
Human    20 EAAGAVDGEG--APPGGPSAQ---AATMRVNEKYST-------------LPAEDRSVHIINICAI 66

  Fly   164 YD------------------DRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAY---------- 200
            .|                  |.||            ...|:|.|..|.:|::|.|
Human    67 EDIGYLPSEGTLLNSLSVDPDAEC------------KYGLYFRDGRRKVDYILVYHHKRPSGNRT 119

  Fly   201 ---RI----------------------------NAHEPTELENTEK---RRVFEANLISQGLEVE 231
               |:                            :...|.:....:|   |..:|.||:..|||:|
Human   120 LVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELE 184

  Fly   232 SSQKDQI---WFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGM 293
            ..:..:|   .|||||||..||.|.||.|||:||.|:                           |
Human   185 RDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK---------------------------M 222

  Fly   294 SVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAH-------RFTAIYSRDKEYLFDIR-QDC 350
            ..:| .|:.:...:..|.|      .:.:.|.||.|.       |.:..:||:|::|||:. :|.
Human   223 YHIN-ETRGLLKKINSVLQ------KITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDS 280

  Fly   351 FFTTAVRSRIVEFILDRQRFPAKNQHDMA--------------------FGIERLIAEGVYSAAY 395
            ||.:..||.||..||.|... .|.::.|.                    :||..|:|.|||:|||
Human   281 FFDSKTRSTIVYEILKRTTC-TKAKYSMGQGEGRKKDSALLSKRRKCGKYGITSLLANGVYAAAY 344

  Fly   396 PLHDGEITETGTM---RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLAS 457
            |||||:.......   |.|||:.||....:|:|||:|.:::|||.||||||||||.||.||:.||
Human   345 PLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPAS 409

  Fly   458 IVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTV 521
            |||:|.|||...::...:|..::|...: ||||||||| .|::|.:...|..|:.::|.|||:||
Human   410 IVGIIVFLYGCATMDENIPSMEMCDQRH-NITMCPLCDKTCSYWKMSSACATARASHLFDNPATV 473

  Fly   522 FFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEE----HPRPQYLARL------------- 569
            ||:|||:.||..|:|.|||....:.:|||||||:..||    |||.:|.||:
Human   474 FFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKE 538

  Fly   570 --EHIPPTRVDYVTN--------------IKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLA 618
              .|||    :..||              :.:.....||.:.||.:.:...::.:||:.|..:|.
Human   539 KRRHIP----EESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLG 599

  Fly   619 VVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQ 683
            |::||:||.|||.:.:||...|:..|..||:|..:||.::.:|:.:|..:|.:||::|:.:|:..
Human   600 VIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKS 664

  Fly   684 FDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF-DYRQEECSSGGCLTELCIQLAI 747
            |::.|..|.:||:|||.|..|||:|||||:|||.||:|..:| .:|.|||:.||||.||||||:|
Human   665 FEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSI 729

  Fly   748 IMVGKQAF-NTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDK----AKDERWMRDFKLLDWGAR 807
            ||:|||.. |.:.|:.:|...:.:..:     :|...:| ||.    .:.:|:..|:.|..:.
Human   730 IMLGKQLIQNNLFEIGIPKMKKLIRYL-----KLKQQSP-PDHEECVKRKQRYEVDYNLEPFA-- 786

  Fly   808 GLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYR 872
            ||.|||:||::|:||||:|||:|||||.|||||||:|:||||||.:|..:|||:.|.:|||:||.
Human   787 GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYN 851

  Fly   873 ILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVID--SPTLYSLAG 935
            ||..||||:||.|.|:|:||||.||||||.:..:|.||:.|::|.|||.|.|.|  :.|..:...
Human   852 ILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPL 916

  Fly   936 DLS-NITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVE 999
            ||. .:..|||.|:|.||.|..||.:|..|:.:||.||.||:||:|.|..:...|.|.|||:..:
Human   917 DLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKD 981

  Fly  1000 LRDQIRREVYVTNEIIIDQEAHRARF-------ERAK 1029
            :..||.:|..:..|:.:.:|..:.:.       ||.|
Human   982 ISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQK 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	88/319 (28%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	273/618 (44%)
ANO1	NP_001365021.1	Anoct_dimer	95..380	CDD:406563	88/319 (28%)
ANO1	NP_001365021.1	Anoctamin	383..989	CDD:398306	273/618 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I317
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75079
Inparanoid	1	1.050	614	1.000	Inparanoid score	I910
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm8665
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910