DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ANO7

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_011509565.1	Gene:	ANO7 / 50636	HGNCID:	31677	Length:	940	Species:	Homo sapiens

Alignment Length:	1022	Identity:	338/1022 - (33%)
Similarity:	519/1022 - (50%)	Gaps:	169/1022 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 FWRGRDTSQRFLDQEQLSASRESLGAADKRARFAESNAPTL--QLPESAEPR------ANGKRPT 134
            :.|.:..::|:....:.|:......:...|.|..|.::..|  ..|..||.|      |:...|.
Human    28 YCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPG 92

  Fly   135 GNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLA 199
            |.:.......:|..|                                           .|||||.
Human    93 GQQAAACRAGSPAKP-------------------------------------------RIDFVLV 114

  Fly   200 YRIN----------AHEPTELENTEKRRVFEANLISQGLEVESSQKD------QIWFVKIHAPLE 248
            :..:          |.:.|::..| .|..|..||.:.||.|:  |:|      .:.:..:.|...
Human   115 WEEDLKLDRQQDSAARDRTDMHRT-WRETFLDNLRAAGLCVD--QQDVQDGNTTVHYALLSASWA 176

  Fly   249 VLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQF 313
            ||..|||.|:|::|::| |.|           .|:::....:..:.:.|
Human   177 VLCYYAEDLRLKLPLQE-LPN-----------QASNWSAGLLAWLGIPN---------------- 213

  Fly   314 FLRNIYVDEEIFPKRAHRFTAIYSRDKE---YLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQ 375
                  |..|:.|.....:.:...|..:   :|....||.|||:..|.:|:..||  .:.|..::
Human   214 ------VLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEIL--AKTPYGHE 270

  Fly   376 HDMAFGIERLIAEGVYSAAYPLHDGEITETG--------TMRALLYKHWASVPKWYRYQPLDDIK 432
            .....||.:|:||||.|||:|||||......        ..|.:|::|||...||.:|||||.::
Human   271 KKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVR 335

  Fly   433 EYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWC 497
            .|||.|:.|||||||:||..||.|::||.:.||...|.:.:.:|.:::|.| ..:..|||||..|
Human   336 RYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGS-KDSFEMCPLCLDC 399

  Fly   498 NFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPR 562
            .||.|...|..|:...|.|:..||||::||:.||.|.||.|||.||.:.:|||.:.::..||.||
Human   400 PFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPR 464

  Fly   563 PQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSML 627
            ||:.|   ..|.|..:.:|...||..| .|.:....:....|:::::|:..:.|:::::||..|.
Human   465 PQFAA---SAPMTAPNPITGEDEPYFP-ERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMA 525

  Fly   628 AALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKI 692
            ..:....:.:..:.|..:|:.:.:.|||..:.||:.:|..||..||..||.||||:|:|:.|||:
Human   526 IVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKV 590

  Fly   693 YLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNT 757
            ::.||||:|:|..|||||||:|||:||.|:.||..|.|||::||||.||..:|.:||||||..|.
Human   591 FIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINN 655

  Fly   758 ILEVYLPM---FWRKV----LAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLE 815
            :.||.:|.   :|:|.    ...:.|.|...:..|         |..|::|:.  ..|||.||||
Human   656 MQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGP---------WEDDYELVP--CEGLFDEYLE 709

  Fly   816 MVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKL 880
            ||||:|||||||||.||||.||||||.:|:||||:|.:..::|||::|.:|||:|:.||..:..|
Human   710 MVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHL 774

  Fly   881 SVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRY 945
            :||:|.|::||:||.:||..||.  .:...|.|:|||||:.     :|:.::.|.:    .||||
Human   775 AVISNAFLLAFSSDFLPRAYYRW--TRAHDLRGFLNFTLAR-----APSSFAAAHN----RTCRY 828

  Fly   946 TDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYV 1010
            ..||     .:....|..::.:||.||.||:|||:.|..|..|:...:||:...:..:::||.|:
Human   829 RAFR-----DDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYL 888

  Fly  1011 TNEIIIDQE----AHRARFERAKRSSSVLQTPVD-----QDMDAASI 1048
            ..:.:.:.|    .:..:.|:.:.|    :.|:|     |...||::
Human   889 AKQALAENEVLFGTNGTKDEQPEGS----ELPLDTLHGSQGQPAAAV 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	70/268 (26%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	238/582 (41%)
ANO7	XP_011509565.1	Anoct_dimer	106..331	CDD:292796	71/306 (23%)
ANO7	XP_011509565.1	Anoctamin	334..885	CDD:282414	238/582 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950