Protein Alignment subdued and ANO7

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_047300552.1
• Gene: ANO7 / 50636
• HGNCID: 31677
• Length: 928
• Species: Homo sapiens
• Alignment Length: 1014
• Identity: 338/1014 - (33%)
• Similarity: 510/1014 - (50%)
• Gaps: 159/1014 - (15%)

  Fly    97 SRESLGAADKRARF----AESNAPTLQL---PESAEPR------ANGKRPTGNRTNPSNPAAPLL 148
            |..|.|:...|:|.    |:....|:.:   |..||.|      |:...|.|.:.......:|..
Human     3 SETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAK 67

  Fly   149 PMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRIN---------- 203
            |                                          |..||||.:..:
Human    68 P------------------------------------------RIADFVLVWEEDLKLDRQQDSA 90

  Fly   204 AHEPTELENTEKRRVFEANLISQGLEVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLC 268
            |.:.|::..| .|..|..||.:.||.|:.:..:. |......|   .|.:..  .||.|.:...|
Human    91 ARDRTDMHRT-WRETFLDNLRAAGLCVDQALTEP-WVPTAGRP---GREHHS--ALRPPQRLLGC 148

  Fly   269 NLRISERSNRLRNAAHYLTNKI--PGMSVVNRST-------KSVFSSLKHVFQFFLRNIYVDE-- 322
            .|.:     |.|.|.......:  ||:.:|.|..       :......:...:..|..:..::
Human   149 ALLL-----RRRPAPEAALAGVTQPGLQLVGRPAGMAGHPQRPAGGCARRTPRVLLLPVQSEQAA 208

  Fly   323 EIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIA 387
            .:.|...|     .|....:|....||.|||:..|.:|:..||  .:.|..::.....||.:|:|
Human   209 TLPPNLLH-----CSHAHSFLGSDNQDTFFTSTKRHQILFEIL--AKTPYGHEKKNLLGIHQLLA 266

  Fly   388 EGVYSAAYPLHDGEITETG--------TMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFA 444
            |||.|||:|||||......        ..|.:|::|||...||.:|||||.::.|||.|:.||||
Human   267 EGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFA 331

  Fly   445 WLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYA 509
            |||:||..||.|::||.:.||...|.:.:.:|.:::|.| ..:..|||||..|.||.|...|..|
Human   332 WLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGS-KDSFEMCPLCLDCPFWLLSSACALA 395

  Fly   510 KVT----YLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLE 570
            :|.    .|.|:..||||::||:.||.|.||.|||.||.:.:|||.:.::..||.||||:.|
Human   396 QVREEAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAA--- 457

  Fly   571 HIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGAS 635
            ..|.|..:.:|...||..| .|.:....:....|:::::|:..:.|:::::||..|...:....:
Human   458 SAPMTAPNPITGEDEPYFP-ERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGN 521

  Fly   636 PMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNY 700
            .:..:.|..:|:.:.:.|||..:.||:.:|..||..||..||.||||:|:|:.|||:::.||||:
Human   522 TLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNF 586

  Fly   701 YASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPM 765
            |:|..|||||||:|||:||.|:.||..|.|||::||||.||..:|.:||||||..|.:.||.:|.
Human   587 YSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPK 651

  Fly   766 ---FWRKV----LAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFV 823
               :|:|.    ...:.|.|...:..|         |..|::|:.  ..|||.||||||||:|||
Human   652 LKGWWQKFRLRSKKRKAGASAGASQGP---------WEDDYELVP--CEGLFDEYLEMVLQFGFV 705

  Fly   824 TIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFI 888
            ||||||.||||.||||||.:|:||||:|.:..::|||::|.:|||:|:.||..:..|:||:|.|:
Human   706 TIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFL 770

  Fly   889 IAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPS 953
            :||:||.:||..||.  .:...|.|:|||||:.     :|:.::.|.:    .||||..||
Human   771 LAFSSDFLPRAYYRW--TRAHDLRGFLNFTLAR-----APSSFAAAHN----RTCRYRAFR---- 820

  Fly   954 SPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQ 1018
             .:....|..::.:||.||.||:|||:.|..|..|:...:||:...:..:::||.|:..:.:.:.
Human   821 -DDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAEN 884

  Fly  1019 E----AHRARFERAKRSSSVLQTPVD-----QDMDAASI 1048
            |    .:..:.|:.:.|    :.|:|     |...||::
Human   885 EVLFGTNGTKDEQPEGS----ELPLDTLHGSQGQPAAAV 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	69/270 (26%)
		Anoctamin	431..1007	CDD:461349	239/586 (41%)
ANO7	XP_047300552.1	Anoct_dimer	67..315	CDD:465044	70/308 (23%)
		Anoctamin	318..873	CDD:461349	239/586 (41%)