Protein Alignment subdued and Ano9

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_001419388.1
• Gene: Ano9 / 499287
• RGDID: 1560565
• Length: 753
• Species: Rattus norvegicus
• Alignment Length: 771
• Identity: 261/771 - (33%)
• Similarity: 403/771 - (52%)
• Gaps: 106/771 - (13%)

  Fly   306 SLKHV--FQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDC------------------ 350
            |.|||  .|.||       |...:....|..:..: |:..|.||.|.
  Rat    47 SQKHVQRQQQFL-------EKLERNGFHFKVLKDQ-KKVFFGIRADSAVIDMYRTLLMKPEDPRS 103

  Fly   351 -----FFTTAVRSRIVEFILD-RQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMR 409
                 |.....|.|||.|::: ::|...:.:....|  |.|:.:||:...:.||.||..
  Rat   104 RAKQNFNIATTRIRIVNFVVNSKKRLSGELRWADTF--EDLVKDGVFETMFLLHKGEED------ 160

  Fly   410 ALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNY 474
              |.:.||.....::.||:|.|:||||.|:.|||.|||:|||||:.|::||:|.|| |.|:|.:.
  Rat   161 --LSREWAQWRNVFQPQPIDKIREYFGEKVALYFTWLGWYTYMLVPAAVVGLIVFL-SGFALFDS 222

  Fly   475 VPV-KDICQSGNTNITMCPLCDWC-NFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLEL 537
            ..: |:||.:  .:|.||||.|.. .:..|.|.|.:||:|:|.||..||.||:||:.|||:|||:
  Rat   223 SQISKEICSA--DDIFMCPLGDNSRRYQRLSEMCTFAKLTHLFDNEGTVIFAIFMALWATVFLEI 285

  Fly   538 WKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSF 602
            |||..|.....|:|..:|..||.      ..||.|              ..|.:.:|.....:..
  Rat   286 WKRKRAREVQSWELYEWDEEEEE------MALELI--------------NSPHYELKKHHHSYLS 330

  Fly   603 SVVLLLIALAFVALL-----AVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILN 662
            |.::|:::|..:.|:     .:||||: :.|||.........::|:|:   :.|.|:..::.|:.
  Rat   331 STIILILSLFMICLMIGMAHLLVVYRV-LAAALFSSFLEQQVTTAVVV---TGAVVHYVIIVIMT 391

  Fly   663 YMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD- 726
            .:...:|..|.:.|..||.::.:...|:|.::|||..:::|:.||||..|:..||||:..:|..
  Rat   392 KVNKCVALKLCKFEEPRTFSEQESKFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGL 456

  Fly   727 YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAK 791
            ::.|||...||:.:|.||:||||..||..:..:|...|:...|..::|.  .|....:.:|:.|:
  Rat   457 WKLEECHLSGCMMDLFIQMAIIMGLKQTLSNCIEYLYPLLAHKCRSVQA--YRHGRKSKDPELAE 519

  Fly   792 DERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHH 856
               |.|::.:.......||.|::||::||||.|||||||||||..||.:|::|:||||.|::...
  Rat   520 ---WQRNYHMNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQ 581

  Fly   857 KRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYR-HY--VNKQGT-----LDG 913
            :|.|.::.:|||.|.::|:.||.|:||.||.:|||||:.|||:||: ||  ..|..|     |..
  Rat   582 RRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYGPCRKNQTFTDDCLKD 646

  Fly   914 YLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVF 978
            |:|.:||.|...|......:.|. .|:|.|||.|:|    :...|.||..|:.|||.||.||::|
  Rat   647 YVNHSLSVFYTKDFQDHGRMEGQ-ENVTVCRYRDYR----NDHDYNLSEQFWFILAIRLAFVILF 706

  Fly   979 ENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSV 1034
            |:....:.::..|.:||:...:::::..|.|         :..|.|...:.||:.|
  Rat   707 EHVALCIKLIAAWFVPDVPQSVKNEVLEEKY---------QRIRGRMCFSSRSTDV 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	34/147 (23%)
		Anoctamin	431..1007	CDD:461349	218/591 (37%)
Ano9	NP_001419388.1	Anoctamin	180..735	CDD:461349	218/591 (37%)