DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano1a

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_009301746.1	Gene:	ano1a / 407698	ZFINID:	ZDB-GENE-121127-3	Length:	966	Species:	Danio rerio

Alignment Length:	1040	Identity:	358/1040 - (34%)
Similarity:	542/1040 - (52%)	Gaps:	160/1040 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ELMKRHNLHERLTGKESFWRGRDTSQ-----RFLDQEQLSASRESLGAADKRARFAESNAPTLQL 120
            :|:..::..|:.:|:||.||......     :.:|::....:|:||             .|...|
Zfish    22 KLLGFNSTEEQPSGQESMWRNEKYESVPLDVKGIDEDNSKGTRDSL-------------YPHTTL 73

  Fly   121 PESAEPRANGKRP-------TGNR----------TNPSNPAAPLLPMTDPDFVKGNVGGVYDDRE 168
            .:|.:.....|.|       .|:|          ..|.|        |.....|..:||
Zfish    74 LKSQQADEKPKDPKLWPYFKDGHRRIDYVLTYHIQKPQN--------TGKQSSKSCLGG------ 124

  Fly   169 CSCPREFYQRGEINTSLFFEDCVRSIDFVLA---YRINAHEPTELENTEKRRVFEANLISQGLEV 230
            |.|.:   :||:.|..:        .|..||   .|::.|:.   :...:|..||.||...|||:
Zfish   125 CLCCK---KRGQTNPPV--------PDPELASQEQRLDYHDD---DQRLRREEFEENLREMGLEM 175

  Fly   231 ESSQKDQI---WFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPG 292
            |..:.::|   .|:|||||.|||.|.||.:||:||      .::..|.|:              |
Zfish   176 EKEEGNKIPGVGFLKIHAPWEVLCREAEFMKLKMP------TIKKYEVSH--------------G 220

  Fly   293 MSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIR-QDCFFTTAV 356
            .|:|.::     |.....|...|:....|.:|  :.....:..:||:|::|||:. ::.||.:..
Zfish   221 NSIVEKA-----SRFMQKFTAPLQPKVGDRQI--EHEKHLSYPFSREKQHLFDLSDRNSFFDSKT 278

  Fly   357 RSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTM---RALLYKHWAS 418
            ||.||..||.|.:.   .:.....||..|:..|:|::|||||||:|.:....   |.:||:.|||
Zfish   279 RSSIVYEILKRTKC---TRAKYIMGIISLLGNGIYTSAYPLHDGDIDDVHAEINDRKILYEEWAS 340

  Fly   419 VPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQS 483
            ...:|:|||:..|::|||.|:||||||||.||.||:.|:|||||.|||...::.:.:|..:||..
Zfish   341 YSIFYKYQPIGLIRKYFGEKVGLYFAWLGVYTQMLIPAAIVGVIVFLYGCATVDDNIPSMEICDE 405

  Fly   484 GNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITH 547
            .| ||||||:|| .|::|.|...|..|:.::|.||.:|||||:||:.||.:|:|.|||....:.:
Zfish   406 RN-NITMCPMCDRACSYWKLVTACGTARASHLFDNAATVFFAIFMALWAAMFMEHWKRRQVRLNY 469

  Fly   548 RWDLTGFDVHE----EHPRPQY-------LARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFS 601
            .||||||:..|    .|||.:|       ..|.|..|.     ..|:|.....    ::||.:..
Zfish   470 LWDLTGFEDTEGKQKSHPRAEYEFHVMKKSLRKEKSPK-----AGNVKLTCTD----RMPAYMTI 525

  Fly   602 FSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYN 666
            ...::.||.:....:..||:||:|::.||.:.::|...|:.......:.|.:||.::.|::.:|.
Zfish   526 IITMIFLICVTLAIVFGVVLYRVSIMTALHMSSTPTFRSNIRATVKTTGAIINLIIIIIMDEVYG 590

  Fly   667 HLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF-DYRQE 730
            .:|.:||.:|:.:|...|::.|..|.::|:|.|.:..|.|:|||:|:.:|.||:|..:. .||.|
Zfish   591 AVARWLTIMEVPKTDKSFEERLIFKTFVLKFANAFTPIVYLAFFRGRLIGRPGKYIYVMGSYRME 655

  Fly   731 ECSSGGCLTELCIQLAIIMVGKQAF-NTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDE- 793
            ||:..|||.||||||.|.|:|||.. |.:.|:.:|.           :.:|........|.::|
Zfish   656 ECAHAGCLMELCIQLCITMLGKQLIQNNLFEIGVPK-----------IKKLLRQRKIDPKHQEEL 709

  Fly   794 -----RWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLL 853
                 |..:|..|..:  .||.|||:||::|:|.||:|||:|||||.|||||||:|:||||||.:
Zfish   710 NKTLHRHEKDHFLGPF--VGLNPEYMEMIIQFGMVTLFVASFPLAPLFALLNNIIEIRLDAKKFV 772

  Fly   854 THHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFT 918
            |..:||::.|.:|||:||.:|..:.|::||.|.|:|:||||.||||||::..:..|||.|::|.|
Zfish   773 TELRRPIAVRAKDIGIWYTLLRGLSKVAVIVNAFVISFTSDFIPRLVYQYMYSPDGTLHGFVNHT 837

  Fly   919 LSEFKVI-----DSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVF 978
            ||.|.|.     ..|......|  ..:.||||.|:|.||.|...|..|..|:.|||.|..||::|
Zfish   838 LSYFNVTHFQPGTEPLEPMHLG--YQVDTCRYKDYRDPPWSDTPYEFSREFWAILAARFAFVILF 900

  Fly   979 ENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDM 1043
            :|.|.|:...|.|.|||:..::..:|.:|    ..:||:....|   |:.|:..:.:..|..|.:
Zfish   901 QNVVMLMSDFVDWLIPDIPKDISLKIHKE----RNLIIELFMKR---EQGKKYRNTMNDPSPQPL 958

Fly 1044 1043
Zfish 959 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	78/251 (31%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	242/600 (40%)
ano1a	XP_009301746.1	Anoct_dimer	91..350	CDD:292796	91/316 (29%)
ano1a	XP_009301746.1	Anoctamin	353..930	CDD:282414	243/605 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75079
Inparanoid	1	1.050	611	1.000	Inparanoid score	I883
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm6575
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980