DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano7

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_001004071.1	Gene:	Ano7 / 367318	RGDID:	1302987	Length:	860	Species:	Rattus norvegicus

Alignment Length:	902	Identity:	333/902 - (36%)
Similarity:	503/902 - (55%)	Gaps:	106/902 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 LLPMTDPDFVKG-NVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYR--INAHEPT 208
            |:.||.|:...| :.|......|..       :.::..|.........|||||.:.  :.:.|..
  Rat    14 LIDMTSPEAGNGCSYGSTAQASEAG-------KQQVAPSRVGSSANPPIDFVLVWEEDLRSRENP 71

  Fly   209 ELENTEK----RRVFEANLISQGLEVESSQKD------QIWFVKIHAPLEVLRRYAEILKLRMPM 263
            ..:.|:.    |..|..||...||:::  |:|      .:.::.:.||..||..|||.|:|::|:
  Rat    72 TQDKTDTHEIWRETFLENLRVAGLKID--QRDVQDEAAAVHYILLSAPWAVLCYYAEDLRLKLPL 134

  Fly   264 KESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPK- 327
            :| |.|           .|:::....:..:.:.|               ..|.|:   .:..|:
  Rat   135 QE-LPN-----------QASNWSATLLEWLGIPN---------------ILLENV---PDTPPEY 169

  Fly   328 RAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYS 392
            .:.:|.|  |:.:.:|....||.|||:..|.:|:..||  .:.|..:|....|||::|:||||:|
  Rat   170 YSCQFKA--SKLQWFLGSDNQDTFFTSTKRHQILFEIL--AKTPYGHQKKGLFGIDQLLAEGVFS 230

  Fly   393 AAYPLHDGE---ITETG-----TMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYY 449
            ||:|||||.   :.|:.     |.|.:|:||||...||.:|||||.::.|||.|:.|||||||:|
  Rat   231 AAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFAWLGFY 295

  Fly   450 TYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYL 514
            |..||.|::||.:.||...|.:.:.||.:::|.|.:| ..|||||..|:||.|...|..|:...|
  Rat   296 TGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSSDT-FDMCPLCSDCSFWLLSSACTLAQAGRL 359

  Fly   515 IDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDY 579
            .|:..||||::||:.||.|.||.|||.:|.:.:|||.:.::..||.||||:.|.   .|.|.::.
  Rat   360 FDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPRPQFAAT---APMTALNP 421

  Fly   580 VTNIKEPTVP---FWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSS 641
            :|...||..|   ..|..|..:|    |:|:::|:..:.|:::::||..|...:....:...::.
  Rat   422 ITGEDEPYFPEKNRVRRMLAGSV----VLLMMVAVVIMCLVSIILYRAVMAIIVSKSNNAFLSAW 482

  Fly   642 AIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFY 706
            |..:|:.:.:.|||..:.||:.:|..||:.||..||.||||.|:|:.|||:::.||||:|||..|
  Rat   483 ASRIASLTGSVVNLVFILILSKVYVILAQVLTRWEMHRTQTAFEDAFTLKVFIFQFVNFYASPVY 547

  Fly   707 IAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMF---WR 768
            ||||||:|||:||.|:.||..|.|||.:||||:||..:|.:||||||..|.:.||.:|..   |:
  Rat   548 IAFFKGRFVGYPGNYHTLFGVRNEECPAGGCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQ 612

  Fly   769 KVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLA 833
            |:.:.:.......|..|         |..|::||.  ..|||.||||||||:|||||||||.|||
  Rat   613 KLCSRRKKAGMGANPAP---------WEADYELLP--CEGLFHEYLEMVLQFGFVTIFVAACPLA 666

  Fly   834 PFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPR 898
            |.||||||.:|:||||:|.:..::|||::|.:|||:|:.||..:..|:||:|.|::||:||.:||
  Rat   667 PLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPR 731

  Fly   899 LVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSM 963
            :.|..  .:...|.|:|||||:.     :|..::.|.:    .||||..||     .:....|..
  Rat   732 VYYSW--TRAPDLRGFLNFTLAR-----APPTFTSAHN----RTCRYRAFR-----DDDGHYSPT 780

  Fly   964 FYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEA 1020
            ::.:||.||.||:|||:.|......:...:||:...:..:::||.|:..:.:.|.||
  Rat   781 YWTLLAIRLAFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADNEA 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	76/262 (29%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	240/581 (41%)
Ano7	NP_001004071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..50		4/32 (13%)
		Anoct_dimer	54..274	CDD:292796	76/255 (30%)
		Anoctamin	277..824	CDD:282414	240/581 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820