Protein Alignment subdued and ANO9

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_001012302.2
• Gene: ANO9 / 338440
• HGNCID: 20679
• Length: 782
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 243/671 - (36%)
• Similarity: 374/671 - (55%)
• Gaps: 59/671 - (8%)

  Fly   353 TTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWA 417
            ||::|.|||.|::      ..|:.......|.|:.:||:.|.:|||.||        ..|.|.||
Human   115 TTSLRIRIVNFVV------MNNKTSAGETFEDLMKDGVFEARFPLHKGE--------GRLKKTWA 165

  Fly   418 SVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPV-KDIC 481
            .....:|.||:|:|:.|||.|:.|||.|||:|||||:.|::.|::.|| |.|||.....: |:||
Human   166 RWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFL-SGFSLFEASQISKEIC 229

  Fly   482 QSGNTNITMCPLCDWC-NFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEI 545
            ::  .:|.||||.|.. .:..|.|||.:||:|:|.||..||.||:||:.|||:|||:|||..|.:
Human   230 EA--HDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARV 292

  Fly   546 THRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPAT---VFSFSVVLL 607
            ...|||..:|..:|    :...:|.:.|    ||...      |:....|.:|   |.:..::.|
Human   293 VLHWDLYVWDEEQE----EMALQLINCP----DYKLR------PYQHSYLRSTVILVLTLLMICL 343

  Fly   608 LIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYL 672
            :|.:|.|    :||||:...|.....|.|............:.|.|:...:.|:..:...:|..|
Human   344 MIGMAHV----LVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKL 404

  Fly   673 TELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGG 736
            .:.||.||.::.:...|::.:.|||..:::|:.||||..|:..||||:..:|.. ::.|||.:.|
Human   405 CDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASG 469

  Fly   737 CLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKL 801
            |:.:|.:|:||||..||..:..:|..:|....|..:::...|   .:.|...:.:|  |.|::.|
Human   470 CMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASES---GHLPRDPELRD--WRRNYLL 529

  Fly   802 LDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRD 866
            .......||.|::||::||||.|||||||||||..||.:|::|:||||.|::...:|.|.::.:|
Human   530 NPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKD 594

  Fly   867 IGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVN---KQGT-----LDGYLNFTLSEFK 923
            ||.|.::|:.||.|:||.||.:|||||:.|||:||::..:   |:|.     |.||:|.:||.|.
Human   595 IGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFH 659

  Fly   924 VIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMIL 988
            ..|......:.|. .|:|.|||.|:|.||.    |..|..|:.:||.||.||::||:....:.::
Human   660 TKDFQDPDGIEGS-ENVTLCRYRDYRNPPD----YNFSEQFWFLLAIRLAFVILFEHVALCIKLI 719

  Fly   989 VRWCIPDMSVELRDQIRREVY 1009
            ..|.:||:...:::::....|
Human   720 AAWFVPDIPQSVKNKVLEVKY 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	24/74 (32%)
		Anoctamin	431..1007	CDD:461349	216/589 (37%)
ANO9	NP_001012302.2	Anoct_dimer	<115..176	CDD:465044	24/74 (32%)
		Anoctamin	179..737	CDD:461349	216/588 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	756..782