Protein Alignment subdued and Ano4

DIOPT Version :9

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_006513818.1
• Gene: Ano4 / 320091
• MGIID: 2443344
• Length: 1154
• Species: Mus musculus
• Alignment Length: 1171
• Identity: 408/1171 - (34%)
• Similarity: 593/1171 - (50%)
• Gaps: 215/1171 - (18%)

  Fly     3 NLGSAKVGALEEATSPPPFSKDESFQLLERSPH--NPAISPTTTVPLEPP--------------- 50
            ||.||..|:.....|......|.:..:.....|  ||.:....|:|.:.|
Mouse    50 NLSSATTGSYYSCVSQITIGYDVAGPVAIGLTHWKNPYVQGRPTLPSDLPLFLSKDAGIPVYHQS 114

  Fly    51 FT------TPLA-PFDMELMKRHNLHERLTGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRA 108
            ||      |||: |..:.          :|...|:   ..:||..|.|:....|. |:..|:||
Mouse   115 FTRKADLATPLSCPASLS----------ITPVPSY---SSSSQETLSQDTTGLSL-SIHGAEKR- 164

  Fly   109 RFAESNAPTLQLPE--SAEPRANGKR----------PTGNR-----------TNPSNPA------ 144
                     ||:.:  |...|...:|          |.|.|           ||..|..
Mouse   165 ---------LQIHQRRSVASRPGSRRRLPVVRHSSLPPGRRSIKMEASSSGITNGKNKVFHAEGG 220

  Fly   145 ------------APLLPMTDPDF---------VKGNVGGVYDDRE-----CSCPREFYQRGEINT 183
                        .|..|.:|.||         :..:|..::|:.|     |.........|.:.:
Mouse   221 LDLQSHQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNILFDELEAVNSPCKDDDSLLHPGNLTS 285

  Fly   184 S----------------------LFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQ 226
            :                      |:|.|....||::|.||.:..:      ||||.|||.|:.::
Mouse   286 TSEDTSRLEAGGETVRERNKSNGLYFRDGKCRIDYILVYRKSNPQ------TEKREVFERNIRAE 344

  Fly   227 GLEVESSQ---KDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTN 288
            ||::|...   ...|.|||:|||.|||.||||.:.:|||.:..:                :||..
Mouse   345 GLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKI----------------YYLPR 393

  Fly   289 KIPGMSVVNRSTKSVFSSLKHVFQFFL--RNIYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQ 348
            :...||.:::....        |:.:|  :.:.:|:|..|.....  :||.:|:.:.:.|.| .:
Mouse   394 RYKFMSRIDKQISR--------FRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNK 450

  Fly   349 DCFFTTAVRSRIVEFILDRQRF-PAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTM---- 408
            |.||..|.|||||..||.|.:: ..||:    .|:.||:..|.|.||:|||:|......::
Mouse   451 DTFFNNATRSRIVHHILQRIKYEEGKNK----IGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHG 511

  Fly   409 ----RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWF 469
                |.|||:.|||...||:|||||.::.|||.||||||||||:||.||..|:.:|:..|||...
Mouse   512 AVNHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVT 576

  Fly   470 SLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATL 533
            :|.:....|::||:  |:|.|||:|| :|.|..|.::|.|||||:|.||.:||||||||:.|||:
Mouse   577 TLDHCQVSKEVCQA--TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATV 639

  Fly   534 FLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPAT 598
            |||.|||..|.|.:.|||..::..||..|||:.|:  :....|::.::...||...| ..|....
Mouse   640 FLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAK--YSKKERMNPISGKPEPYQAF-TDKCSRL 701

  Fly   599 VFSFSVVLLLIALAFVALLAVVVYR---MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYI 660
            :.|.|.:..:|.:...|:..:|:||   :|..||.|..   :..:::.|..|.:|..:|.|::.:
Mouse   702 IVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWA---LIRNNSQVATTGTAVCINFCIIML 763

  Fly   661 LNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF 725
            ||.:|..:|..||.||..||::::::|.|||::|.||||..:|.||||||.|:|.||||.|.:|.
Mouse   764 LNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLI 828

  Fly   726 D-YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPM---FW-RKVLAIQVGLSRLFNNTP 785
            : :|.|||...|||.:||:|:.||||.||.:|..:|:..|:   :| |:.:..:.|..|
Mouse   829 NRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGTER------ 887

  Fly   786 NPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAK 850
               |....:|.:|:.|....|.|||.|||||:||:||.|||||||||||..||||||:|:||||.
Mouse   888 ---KINFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAY 949

  Fly   851 KLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK-------- 907
            |.:|..:||::.|.:|||:||.||:.||.||||||.|:||.|||.||||||.:....
Mouse   950 KFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAG 1014

  Fly   908 QGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSN-----ITTCRYTDFRLPPSSPEKYTLSSMFYII 967
            |..:.||:|.:||.|::.|.........|.|.     :..|||.|:|.||.|...|..:..|:.:
Mouse  1015 QKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLAPYGYTLQFWHV 1079

  Fly   968 LACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSS 1032
            ||.||.|::|||:.|..:..|:.:.|||:..:|||::|||.|:..|::.:.|..|.:.||.:|..
Mouse  1080 LAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKK 1144

  Fly  1033 S 1033
            :
Mouse  1145 N 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	85/258 (33%)
		Anoctamin	431..1007	CDD:282414	259/597 (43%)
Ano4	XP_006513818.1	Anoct_dimer	310..535	CDD:374413	85/258 (33%)
		Anoctamin	538..1119	CDD:367984	259/597 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5559
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		otm43787
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.960