Protein Alignment subdued and Ano6

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_008763957.1
• Gene: Ano6 / 315272
• RGDID: 1304765
• Length: 932
• Species: Rattus norvegicus
• Alignment Length: 955
• Identity: 366/955 - (38%)
• Similarity: 524/955 - (54%)
• Gaps: 130/955 - (13%)

  Fly   120 LPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTS 184
            :|:|..|......|.        |:..:|...|...|....|.:....:...| ||.:......|
  Rat    27 VPDSRRPFLAPHTPL--------PSGLVLENFDQTIVCSTFGSLESQEDFRTP-EFEEFNGKPDS 82

  Fly   185 LFFEDCVRSIDFVLAY-----RINAHEPTELENTEKRRVFEANLISQGLEVESSQK---DQIWFV 241
            |||.|..|.|||||.|     :.|..:.|..:...||:.:|:||||.||::|:::.   |::.||
  Rat    83 LFFTDGQRRIDFVLVYEDESKKENNKKGTNEKQKRKRQAYESNLISHGLQLEATRSVSDDKLVFV 147

  Fly   242 KIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSS 306
            |:|||.|||..||||:.:::|:|           .|.|:                   |:|.|.:
  Rat   148 KVHAPWEVLCTYAEIMHIKLPLK-----------PNDLK-------------------TRSTFDT 182

  Fly   307 LKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKE---YLFDIRQDCFFTTAVRSRIVEFILDRQ 368
                |.:|.:.:.|:|.:.......|||.:.:.:.   |:.|  :|.||..|.|||||.|||.|.
  Rat   183 ----FNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILD--RDSFFNPATRSRIVYFILSRV 241

  Fly   369 RFPAKNQHDMAFGIERLIAEGVYSAAYPLHD------GEITETGTMRALLYKHWASVPKWYRYQP 427
            ::...|..: .|||.||::.|:|.||:||||      .|.....:.|.|||:.||.....|:.||
  Rat   242 KYQVMNNVN-KFGINRLVSSGIYKAAFPLHDCKFNYKSEDPNCPSERYLLYREWAHPRSIYKKQP 305

  Fly   428 LDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSG-NTNITMC 491
            ||.|::|:|.|||:|||||||||.|||||::|||.||||.:.:..|....|::|... ...|.||
  Rat   306 LDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCDPDIGGQILMC 370

  Fly   492 PLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFD 555
            |.|| .|.||.|..||..:|...:.|:..|:.|||||..|.|||||.|||..||:.:.||.....
  Rat   371 PQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQ 435

  Fly   556 VHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFW------RMKLPATVFSFSVVLLLIALAFV 614
             .||.|||:|.|:..|:.   ::.:|. :|..:||.      |:.|.|:...|.::|::     .
  Rat   436 -QEEQPRPEYEAQCNHVV---INEITQ-EEERIPFTTCGKCIRITLCASAVFFWILLII-----A 490

  Fly   615 ALLAVVVYRMSMLAALKV-------GASPMTTSSAIVLATA-SAAFVNLCLLYILNYMYNHLAEY 671
            :::.::|||:|:......       |..|:.......:||: :|:.::..::.|||.:|..:|..
  Rat   491 SVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIM 555

  Fly   672 LTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGE-YNKLFDYRQEECSSG 735
            :|..|:.||||.:::|||:|::|.||||||:|.||||||||||||:||: ...|..||.|||..|
  Rat   556 ITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 620

  Fly   736 GCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFK 800
            |||.||..||.|||.||..:|.|.||.||  |      .:.|...:......:|. ..||.:|:.
  Rat   621 GCLLELTTQLTIIMGGKAIWNNIQEVLLP--W------VMNLIGRYKRVSGSEKI-TPRWEQDYH 676

  Fly   801 LLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVR 865
            |...|..|||.|||||::|:||||:|||:|||||..||:|||||:|:||.||.|..:|.|.::.:
  Rat   677 LQPMGRLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQ 741

  Fly   866 DIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVY------------RHYVNKQGTLDGYLNFT 918
            |||.|..|:..|..|:|:||..||||||||||||||            .:|     |:|||:|.|
  Rat   742 DIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYY-----TMDGYINNT 801

  Fly   919 LSEFKVID-------SPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVV 976
            ||.|.:.|       :|.:     .|.|.|.|||.|||.||..|::|..:..::.::|.:|.|::
  Rat   802 LSVFNITDFKNTDKENPYI-----GLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFII 861

  Fly   977 VFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAH 1021
            |.|:.:..|...:.:.|||:|...:.:|:||.|:|.:::  .|:|
  Rat   862 VMEHVIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLL--HESH 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	88/258 (34%)
		Anoctamin	431..1007	CDD:461349	255/611 (42%)
Ano6	XP_008763957.1	Anoct_dimer	84..306	CDD:465044	88/258 (34%)
		Anoctamin	309..892	CDD:461349	255/611 (42%)