DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano6

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_008763957.1	Gene:	Ano6 / 315272	RGDID:	1304765	Length:	932	Species:	Rattus norvegicus

Alignment Length:	955	Identity:	366/955 - (38%)
Similarity:	524/955 - (54%)	Gaps:	130/955 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTS 184
            :|:|..|......|.        |:..:|...|...|....|.:....:...| ||.:......|
  Rat    27 VPDSRRPFLAPHTPL--------PSGLVLENFDQTIVCSTFGSLESQEDFRTP-EFEEFNGKPDS 82

  Fly   185 LFFEDCVRSIDFVLAY-----RINAHEPTELENTEKRRVFEANLISQGLEVESSQK---DQIWFV 241
            |||.|..|.|||||.|     :.|..:.|..:...||:.:|:||||.||::|:::.   |::.||
  Rat    83 LFFTDGQRRIDFVLVYEDESKKENNKKGTNEKQKRKRQAYESNLISHGLQLEATRSVSDDKLVFV 147

  Fly   242 KIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSS 306
            |:|||.|||..||||:.:::|:|           .|.|:                   |:|.|.:
  Rat   148 KVHAPWEVLCTYAEIMHIKLPLK-----------PNDLK-------------------TRSTFDT 182

  Fly   307 LKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKE---YLFDIRQDCFFTTAVRSRIVEFILDRQ 368
                |.:|.:.:.|:|.:.......|||.:.:.:.   |:.|  :|.||..|.|||||.|||.|.
  Rat   183 ----FNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILD--RDSFFNPATRSRIVYFILSRV 241

  Fly   369 RFPAKNQHDMAFGIERLIAEGVYSAAYPLHD------GEITETGTMRALLYKHWASVPKWYRYQP 427
            ::...|..: .|||.||::.|:|.||:||||      .|.....:.|.|||:.||.....|:.||
  Rat   242 KYQVMNNVN-KFGINRLVSSGIYKAAFPLHDCKFNYKSEDPNCPSERYLLYREWAHPRSIYKKQP 305

  Fly   428 LDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSG-NTNITMC 491
            ||.|::|:|.|||:|||||||||.|||||::|||.||||.:.:..|....|::|... ...|.||
  Rat   306 LDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCDPDIGGQILMC 370

  Fly   492 PLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFD 555
            |.|| .|.||.|..||..:|...:.|:..|:.|||||..|.|||||.|||..||:.:.||.....
  Rat   371 PQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQ 435

  Fly   556 VHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFW------RMKLPATVFSFSVVLLLIALAFV 614
             .||.|||:|.|:..|:.   ::.:|. :|..:||.      |:.|.|:...|.::|::     .
  Rat   436 -QEEQPRPEYEAQCNHVV---INEITQ-EEERIPFTTCGKCIRITLCASAVFFWILLII-----A 490

  Fly   615 ALLAVVVYRMSMLAALKV-------GASPMTTSSAIVLATA-SAAFVNLCLLYILNYMYNHLAEY 671
            :::.::|||:|:......       |..|:.......:||: :|:.::..::.|||.:|..:|..
  Rat   491 SVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIM 555

  Fly   672 LTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGE-YNKLFDYRQEECSSG 735
            :|..|:.||||.:::|||:|::|.||||||:|.||||||||||||:||: ...|..||.|||..|
  Rat   556 ITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 620

  Fly   736 GCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFK 800
            |||.||..||.|||.||..:|.|.||.||  |      .:.|...:......:|. ..||.:|:.
  Rat   621 GCLLELTTQLTIIMGGKAIWNNIQEVLLP--W------VMNLIGRYKRVSGSEKI-TPRWEQDYH 676

  Fly   801 LLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVR 865
            |...|..|||.|||||::|:||||:|||:|||||..||:|||||:|:||.||.|..:|.|.::.:
  Rat   677 LQPMGRLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQ 741

  Fly   866 DIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVY------------RHYVNKQGTLDGYLNFT 918
            |||.|..|:..|..|:|:||..||||||||||||||            .:|     |:|||:|.|
  Rat   742 DIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYY-----TMDGYINNT 801

  Fly   919 LSEFKVID-------SPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVV 976
            ||.|.:.|       :|.:     .|.|.|.|||.|||.||..|::|..:..::.::|.:|.|::
  Rat   802 LSVFNITDFKNTDKENPYI-----GLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFII 861

  Fly   977 VFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAH 1021
            |.|:.:..|...:.:.|||:|...:.:|:||.|:|.:::  .|:|
  Rat   862 VMEHVIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLL--HESH 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	88/258 (34%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	255/611 (42%)
Ano6	XP_008763957.1	Anoct_dimer	84..306	CDD:292796	88/258 (34%)
Ano6	XP_008763957.1	Anoctamin	309..893	CDD:282414	256/612 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5236
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.830