DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano3

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_038962388.1	Gene:	Ano3 / 311287	RGDID:	1308873	Length:	981	Species:	Rattus norvegicus

Alignment Length:	997	Identity:	369/997 - (37%)
Similarity:	532/997 - (53%)	Gaps:	134/997 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 TSQRFL--DQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAP 146
            ||..||  |:.:...|.||...:..:..||:.:...|.|.:..:.....:....:|:...|
  Rat    68 TSVTFLSADKPEHVTSEESRKDSTLKCSFADLSEFCLALGKDKDYMDESEHANYDRSRLLN---- 128

  Fly   147 LLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEIN----TSLFFEDCVRSIDFVLAYRINAHEP 207
                   |||      ..|..|   .:....:.::|    :.|.|:|..:.||::|.||     .
  Rat   129 -------DFV------TKDKPE---SKTKLSKNDMNYIASSGLLFKDGKKRIDYILVYR-----K 172

  Fly   208 TELENTEKRRVFEANLISQGLEVESS---QKDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCN 269
            |.:: .:||..||.||.::||.:|..   ....|.|:|:|.|.:.|.:|||.|.:|:|
  Rat   173 TNIQ-YDKRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLNIRVP------- 229

  Fly   270 LRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRN-IYVDEEIFP--KRAHR 331
                     .|...:|...|       |:|...|....|.:.::..:| :.:|:..||  :.:..
  Rat   230 ---------FRKKCYYTDQK-------NKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDC 278

  Fly   332 FTAIYSRDKEYLFDI-RQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMA-FGIERLIAEGVYSAA 394
            :|..:||.:.:.|.| .:|.||:.|.|||||..:|:|.::    ::.:: .||.:||..|.|.||
  Rat   279 YTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKY----ENGISKVGIRKLINNGSYIAA 339

  Fly   395 YPLHDG------EITETGTM--RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTY 451
            :|.|:|      .|...|..  |.|||:.||....||::||||.|:.|||.||||||||||:||.
  Rat   340 FPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTG 404

  Fly   452 MLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDW-CNFWDLKETCNYAKVTYLI 515
            ||:.|::||:..|.|...::......::||::  |.:.||||||. |:...|.::|.|||||||.
  Rat   405 MLIPAAVVGLCVFFYGLVTMNESQVSQEICKA--TEVFMCPLCDKNCSLQRLNDSCIYAKVTYLF 467

  Fly   516 DNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLA---RLEHIPPTRV 577
            ||..|||||:||:.|||:|||.|||..:.:|:.|||..::..||..|||:.|   |:|.|.|
  Rat   468 DNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEIINP--- 529

  Fly   578 DYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYR---MSMLAALKVGASPMTT 639
              :|...||..|. ..|:...:.|.|.:..:|:|...|:.||||||   |...|:.|........
  Rat   530 --ITGKPEPHQPS-SDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHW 591

  Fly   640 SSAIVLATASAAF-VNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYAS 703
            .    .||:.||. :|..::.:||..|..:|..||.||..||::::::|..||::|.||||..:|
  Rat   592 Q----FATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSS 652

  Fly   704 IFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMF- 766
            |||||||.|:||||||:|||||: :|.|||...|||.:||:|:.:||..||.:|..:|:..|:.
  Rat   653 IFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQ 717

  Fly   767 -WRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAF 830
             |.....|:.|:          ..|...:|..|:.|......||..||||||||:||.|||||||
  Rat   718 NWWSRHKIKRGI----------QDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAF 772

  Fly   831 PLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDM 895
            ||||..||||||:|:||||.|.:|..:||:..|..|||:|..||:.||.|:||||.|:||.|||.
  Rat   773 PLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDY 837

  Fly   896 IPRLVY--------RHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITT-----CRYTD 947
            |||.||        .|....:..|.||:|.:||.|             |||.:..     |||.|
  Rat   838 IPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFF-------------DLSELGIGKSGYCRYRD 889

  Fly   948 FRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTN 1012
            :|.||.|.:.|..:..::.|||.||.|::|||:.|..:...:.:.|||:...||::||||.|:..
  Rat   890 YRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQ 954

  Fly  1013 EIIIDQEAHRARFERAKRSSSV 1034
            |::.:.|....:.:|.|....:
  Rat   955 EMMYEAELEHLQQQRRKSGQPI 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	78/257 (30%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	260/599 (43%)
Ano3	XP_038962388.1	Anoct_dimer	157..381	CDD:406563	78/256 (30%)
Ano3	XP_038962388.1	Anoctamin	384..949	CDD:398306	260/599 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930