Protein Alignment subdued and Ano3

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_001417331.1
• Gene: Ano3 / 311287
• RGDID: 1308873
• Length: 981
• Species: Rattus norvegicus
• Alignment Length: 997
• Identity: 369/997 - (37%)
• Similarity: 532/997 - (53%)
• Gaps: 134/997 - (13%)

  Fly    84 TSQRFL--DQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAP 146
            ||..||  |:.:...|.||...:..:..||:.:...|.|.:..:.....:....:|:...|
  Rat    68 TSVTFLSADKPEHVTSEESRKDSTLKCSFADLSEFCLALGKDKDYMDESEHANYDRSRLLN---- 128

  Fly   147 LLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEIN----TSLFFEDCVRSIDFVLAYRINAHEP 207
                   |||      ..|..|   .:....:.::|    :.|.|:|..:.||::|.||     .
  Rat   129 -------DFV------TKDKPE---SKTKLSKNDMNYIASSGLLFKDGKKRIDYILVYR-----K 172

  Fly   208 TELENTEKRRVFEANLISQGLEVESS---QKDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCN 269
            |.:: .:||..||.||.::||.:|..   ....|.|:|:|.|.:.|.:|||.|.:|:|
  Rat   173 TNIQ-YDKRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLNIRVP------- 229

  Fly   270 LRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRN-IYVDEEIFP--KRAHR 331
                     .|...:|...|       |:|...|....|.:.::..:| :.:|:..||  :.:..
  Rat   230 ---------FRKKCYYTDQK-------NKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDC 278

  Fly   332 FTAIYSRDKEYLFDI-RQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMA-FGIERLIAEGVYSAA 394
            :|..:||.:.:.|.| .:|.||:.|.|||||..:|:|.::    ::.:: .||.:||..|.|.||
  Rat   279 YTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKY----ENGISKVGIRKLINNGSYIAA 339

  Fly   395 YPLHDG------EITETGTM--RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTY 451
            :|.|:|      .|...|..  |.|||:.||....||::||||.|:.|||.||||||||||:||.
  Rat   340 FPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTG 404

  Fly   452 MLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDW-CNFWDLKETCNYAKVTYLI 515
            ||:.|::||:..|.|...::......::||::  |.:.||||||. |:...|.::|.|||||||.
  Rat   405 MLIPAAVVGLCVFFYGLVTMNESQVSQEICKA--TEVFMCPLCDKNCSLQRLNDSCIYAKVTYLF 467

  Fly   516 DNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLA---RLEHIPPTRV 577
            ||..|||||:||:.|||:|||.|||..:.:|:.|||..::..||..|||:.|   |:|.|.|
  Rat   468 DNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEIINP--- 529

  Fly   578 DYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYR---MSMLAALKVGASPMTT 639
              :|...||..|. ..|:...:.|.|.:..:|:|...|:.||||||   |...|:.|........
  Rat   530 --ITGKPEPHQPS-SDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHW 591

  Fly   640 SSAIVLATASAAF-VNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYAS 703
            .    .||:.||. :|..::.:||..|..:|..||.||..||::::::|..||::|.||||..:|
  Rat   592 Q----FATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSS 652

  Fly   704 IFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMF- 766
            |||||||.|:||||||:|||||: :|.|||...|||.:||:|:.:||..||.:|..:|:..|:.
  Rat   653 IFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQ 717

  Fly   767 -WRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAF 830
             |.....|:.|:          ..|...:|..|:.|......||..||||||||:||.|||||||
  Rat   718 NWWSRHKIKRGI----------QDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAF 772

  Fly   831 PLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDM 895
            ||||..||||||:|:||||.|.:|..:||:..|..|||:|..||:.||.|:||||.|:||.|||.
  Rat   773 PLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDY 837

  Fly   896 IPRLVY--------RHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITT-----CRYTD 947
            |||.||        .|....:..|.||:|.:||.|             |||.:..     |||.|
  Rat   838 IPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFF-------------DLSELGIGKSGYCRYRD 889

  Fly   948 FRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTN 1012
            :|.||.|.:.|..:..::.|||.||.|::|||:.|..:...:.:.|||:...||::||||.|:..
  Rat   890 YRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQ 954

  Fly  1013 EIIIDQEAHRARFERAKRSSSV 1034
            |::.:.|....:.:|.|....:
  Rat   955 EMMYEAELEHLQQQRRKSGQPI 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	78/257 (30%)
		Anoctamin	431..1007	CDD:461349	260/599 (43%)
Ano3	NP_001417331.1	None