Protein Alignment subdued and Ano8

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_038950925.1
• Gene: Ano8 / 306340
• RGDID: 1563946
• Length: 1141
• Species: Rattus norvegicus
• Alignment Length: 1070
• Identity: 226/1070 - (21%)
• Similarity: 351/1070 - (32%)
• Gaps: 435/1070 - (40%)

  Fly   278 RLRNAAHYLTNKIPGMSVVNRSTKSVFSSL-----KHVFQFFLRNIYV--DEEIFPKRAHRFTAI 335
            ||..|..||.:....|..|......|..:.     .|...:.|.:|.|  .|.|...|.||.|..
  Rat    42 RLLQAGRYLVSHKAWMKTVPTEDCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRA 106

  Fly   336 Y-----------------------------------SRDKEYLFD-IRQDC-FFTTAVRSRIVEF 363
            |                                   |.::::::: :..:. |||:..|..|:.|
  Rat   107 YAFFVTATYESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVENELRFFTSQERQSIIRF 171

  Fly   364 ILDRQRFPAKN---QHDMAF-----GIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVP 420
            .|  |...||.   .|::.|     .|..|.|.|:....:|:|:..|...      |.|.|  |.
  Rat   172 WL--QNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNR------LMKSW--VQ 226

  Fly   421 KWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGN 485
            .....||||||.:||||||.:||||||:||..::..::.|.:  ||:
  Rat   227 AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSV--LYT------------------ 271

  Fly   486 TNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRW- 549
                         |.:..:|..         :.|.|.||:|...|:|||||.|||..||:.::|
  Rat   272 -------------FTEADQTSR---------DVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWG 314

  Fly   550 --DLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALA 612
              |..|..|  |.||||:.. :..|.|     :|..:|...|.|:..|...:.|..:.|..:...
  Rat   315 TLDSPGEAV--EEPRPQFRG-IRRISP-----ITRAEEFYYPPWKRLLFQLLVSLPLCLACLVCV 371

  Fly   613 FVALLAVVVYRMSMLAALKVGASPMTTS--SAIVLATASAAFVNLCLLYILNYMYNHLAEYLTEL 675
            ||.:|.  .:::..| .|.|...|....  ..::||         .|:.:....|..||.:|.::
  Rat   372 FVLMLG--CFQLQEL-VLSVKGLPRLVRFLPKVILA---------LLVSVSAEGYKKLAVWLNDM 424

  Fly   676 EMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQE-ECSSGGCLT 739
            |.:|.::.::..|.:|:.|.||||.|.|:|||.|:. |.:....|...|....|. |......|.
  Rat   425 ENYRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYL-KDMDRLKELLLLLSLTQSLERQLRAALV 488

  Fly   740 ELCI--------------------QLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNT 784
            .|..                    .||.:::.:|....:.||..|..:|::.:.::||..:....
  Rat   489 PLAALRFRLLLLSLRGLLLVARAKMLATLLITRQLLQNVREVLQPHLYRRLGSGELGLRTILELA 553

  Fly   785 -----------PNP--------------------------------------------------- 787
                       |:|
  Rat   554 RALLGLLNPLRPDPRRHLEAQADEGGAGSRRCLGGGCGAPEEEEEVAVERRPAGEGGEVPEGPRG 618

  Fly   788 -----------DKAKDERWM-RDFKLLDWGAR--------------------------------- 807
                       |:.:||.:. .:..|||.|.|
  Rat   619 GKEEDEEEDDDDEDEDEEYEGEEGSLLDCGLRLKKVSFAERGAGRRRPGPSPDGLLEEGSPTMVE 683

  Fly   808 -GL-------------------------------------------------------------- 809
             ||
  Rat   684 KGLEPGVFTLAEEDDEPEAPPSSPGPEPQTVLLRRAGGEGRDQGSDGDRDPETGSGDAAGRQKRH 748

  Fly   810 --------------------------------FPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNI 842
                                            |.:|.||.:|:|:|.:|.:|||||...||:||:
  Rat   749 NRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNL 813

  Fly   843 LEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK 907
            :|:|.||.||.|..:||..|||..||.|.::::.:|.|:::.|.::|
  Rat   814 IEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLI------------------ 860

  Fly   908 QGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRL 972
                                    ...|.|..:         .|..|||...:|
  Rat   861 ------------------------GQCGQLQRL---------FPWLSPEAAIVS----------- 881

  Fly   973 GFVVVFENFVALVMILVRWCIPDMSVELRDQI------RREVYVTNEIIIDQEAHRARF---ERA 1028
              |||.|:...||..|:...|||:...:.:::      |||.:..:|    ::|.: ||   :|.
  Rat   882 --VVVLEHLALLVKYLIHAAIPDIPGWVAEEMAKLEYQRREAFKRHE----RQAQQ-RFQQQQRR 939

  Fly  1029 KRSSSVLQTPVDQ----DMDAASIQEPNAK 1054
            :|.....|...:|    :.|....:|..|:
  Rat   940 RREEEERQRHAEQQARRERDTGGREEARAE 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	44/201 (22%)
		Anoctamin	431..1007	CDD:461349	165/809 (20%)
Ano8	XP_038950925.1	Anoctamin	237..>539	CDD:461349	97/364 (27%)
		Anoctamin	<744..913	CDD:461349	53/232 (23%)
		PRK12323	<961..>1139	CDD:481241	2/9 (22%)