DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano4

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_017450215.2	Gene:	Ano4 / 299714	RGDID:	1310252	Length:	1154	Species:	Rattus norvegicus

Alignment Length:	1155	Identity:	401/1155 - (34%)
Similarity:	594/1155 - (51%)	Gaps:	183/1155 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NLGSAKVGALEEATSPPPFSKDESFQLLERSPH--NPAISPTTTVPLEPPF----TTPLAPFDME 61
            ||.||..|:.....|......|.:..:.....|  ||.:....|:|.:.|.    .|.:..:...
  Rat    50 NLSSATTGSYYSCVSQITIGYDVAGPVAIGLTHWKNPYVQGRPTLPSDLPLFLSKDTSIPVYHQS 114

  Fly    62 LMKRHNLHERL--------TGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRARFAE------ 112
            ..::.:|...|        |...|:   ..:||..|.|:....|. |:..|:||.:..:
  Rat   115 FTRKADLATPLSCPASLSITPVPSY---SSSSQETLSQDTTGLSL-SIHGAEKRLQIHQRRSVAS 175

  Fly   113 -------------SNAP----TLQLPESAEPRANGKRPTGNRTNPSNPAAPLL------------ 148
                         |:.|    ::::..|:....|||    |:...:.....|.
  Rat   176 RPGSRRRLPVVRHSSLPPGRRSIKMEASSSGITNGK----NKVFHAEGGVDLQNHQLDMQTLSDG 236

  Fly   149 PMTDPDF---------VKGNVGGVYDDRE-----CSCPREFYQRGEINTS--------------- 184
            |.:|.||         :..:|...:|:.|     |.........|.:.::
  Rat   237 PKSDVDFSEILNAIQEMAKDVNIFFDELEAVNSPCKDDDSLLHPGNLTSTSEDTSRLEAGGEKVR 301

  Fly   185 -------LFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQ---KDQIW 239
                   |:|.|....||::|.||.:..:      ||||.|||.|:.::||::|...   ...|.
  Rat   302 ERNKSNGLYFRDGKCRIDYILVYRKSNPQ------TEKREVFERNIRAEGLQMEKESSLINSDII 360

  Fly   240 FVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVF 304
            |||:|||.|||.||||.:.:|||.:..:                :||..:...||.:::....
  Rat   361 FVKLHAPWEVLGRYAEQMNVRMPFRRKI----------------YYLPRRYKFMSRIDKQISR-- 407

  Fly   305 SSLKHVFQFFL--RNIYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQDCFFTTAVRSRIVEFI 364
                  |:.:|  :.:.:|:|..|.....  :||.:|:.:.:.|.| .:|.||..|.|||||..|
  Rat   408 ------FRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHI 466

  Fly   365 LDRQRF-PAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTM--------RALLYKHWASVP 420
            |.|.:: ..||:    .|:.||:..|.|.||:|||:|......::        |.|||:.|||..
  Rat   467 LQRIKYEEGKNK----IGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWS 527

  Fly   421 KWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGN 485
            .||:|||||.::.|||.||||||||||:||.||..|:.:|:..|||...:|.:....|::||:
  Rat   528 VWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHCQVSKEVCQA-- 590

  Fly   486 TNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRW 549
            |:|.|||:|| :|.|..|.::|.|||||:|.||.:||||||||:.|||:|||.|||..|.|.:.|
  Rat   591 TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDW 655

  Fly   550 DLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFV 614
            ||..::..||..|||:.|:  :....|::.::...||...| ..|....:.|.|.:..:|.:...
  Rat   656 DLIDWEEEEEEIRPQFEAK--YSKKERMNPISGKPEPYQAF-TDKCSRLIVSASGIFFMICVVIA 717

  Fly   615 ALLAVVVYR---MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELE 676
            |:..:|:||   :|..||.|..   :..:::.|..|.:|..:|.|::.:||.:|..:|..||.||
  Rat   718 AVFGIVIYRVVTVSTFAAFKWA---LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLE 779

  Fly   677 MWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTE 740
            ..||::::::|.|||::|.||||..:|.||||||.|:|.||||.|.:|.: :|.|||...|||.:
  Rat   780 QPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLID 844

  Fly   741 LCIQLAIIMVGKQAFNTILEVYLPM---FW-RKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKL 801
            ||:|:.||||.||.:|..:|:..|:   :| |:.:..:.|..|         |....:|.:|:.|
  Rat   845 LCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGTER---------KINFPQWEKDYNL 900

  Fly   802 LDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRD 866
            ....|.|||.|||||:||:||.|||||||||||..||||||:|:||||.|.:|..:||::.|.:|
  Rat   901 QPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKD 965

  Fly   867 IGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK--------QGTLDGYLNFTLSEFK 923
            ||:||.||:.||.||||||.|:||.|||.||||||.:....        |..:.||:|.:||.|:
  Rat   966 IGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFR 1030

  Fly   924 VIDSPTLYSLAGDLSN-----ITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVA 983
            :.|.........|.|.     :..|||.|:|.||.|...|..:..|:.:||.||.|::|||:.|.
  Rat  1031 ISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVF 1095

  Fly   984 LVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSS 1033
            .:..|:.:.|||:..:|||::|||.|:..|::.:.|..|.:.||.:|..:
  Rat  1096 CIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKN 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	85/258 (33%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	259/597 (43%)
Ano4	XP_017450215.2	Anoct_dimer	310..535	CDD:406563	85/258 (33%)
Ano4	XP_017450215.2	Anoctamin	538..1119	CDD:398306	259/597 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5236
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830