Protein Alignment subdued and Ano4

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_017450215.2
• Gene: Ano4 / 299714
• RGDID: 1310252
• Length: 1154
• Species: Rattus norvegicus
• Alignment Length: 1155
• Identity: 401/1155 - (34%)
• Similarity: 594/1155 - (51%)
• Gaps: 183/1155 - (15%)

  Fly     3 NLGSAKVGALEEATSPPPFSKDESFQLLERSPH--NPAISPTTTVPLEPPF----TTPLAPFDME 61
            ||.||..|:.....|......|.:..:.....|  ||.:....|:|.:.|.    .|.:..:...
  Rat    50 NLSSATTGSYYSCVSQITIGYDVAGPVAIGLTHWKNPYVQGRPTLPSDLPLFLSKDTSIPVYHQS 114

  Fly    62 LMKRHNLHERL--------TGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRARFAE------ 112
            ..::.:|...|        |...|:   ..:||..|.|:....|. |:..|:||.:..:
  Rat   115 FTRKADLATPLSCPASLSITPVPSY---SSSSQETLSQDTTGLSL-SIHGAEKRLQIHQRRSVAS 175

  Fly   113 -------------SNAP----TLQLPESAEPRANGKRPTGNRTNPSNPAAPLL------------ 148
                         |:.|    ::::..|:....|||    |:...:.....|.
  Rat   176 RPGSRRRLPVVRHSSLPPGRRSIKMEASSSGITNGK----NKVFHAEGGVDLQNHQLDMQTLSDG 236

  Fly   149 PMTDPDF---------VKGNVGGVYDDRE-----CSCPREFYQRGEINTS--------------- 184
            |.:|.||         :..:|...:|:.|     |.........|.:.::
  Rat   237 PKSDVDFSEILNAIQEMAKDVNIFFDELEAVNSPCKDDDSLLHPGNLTSTSEDTSRLEAGGEKVR 301

  Fly   185 -------LFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQ---KDQIW 239
                   |:|.|....||::|.||.:..:      ||||.|||.|:.::||::|...   ...|.
  Rat   302 ERNKSNGLYFRDGKCRIDYILVYRKSNPQ------TEKREVFERNIRAEGLQMEKESSLINSDII 360

  Fly   240 FVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVF 304
            |||:|||.|||.||||.:.:|||.:..:                :||..:...||.:::....
  Rat   361 FVKLHAPWEVLGRYAEQMNVRMPFRRKI----------------YYLPRRYKFMSRIDKQISR-- 407

  Fly   305 SSLKHVFQFFL--RNIYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQDCFFTTAVRSRIVEFI 364
                  |:.:|  :.:.:|:|..|.....  :||.:|:.:.:.|.| .:|.||..|.|||||..|
  Rat   408 ------FRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHI 466

  Fly   365 LDRQRF-PAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTM--------RALLYKHWASVP 420
            |.|.:: ..||:    .|:.||:..|.|.||:|||:|......::        |.|||:.|||..
  Rat   467 LQRIKYEEGKNK----IGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWS 527

  Fly   421 KWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGN 485
            .||:|||||.::.|||.||||||||||:||.||..|:.:|:..|||...:|.:....|::||:
  Rat   528 VWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHCQVSKEVCQA-- 590

  Fly   486 TNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRW 549
            |:|.|||:|| :|.|..|.::|.|||||:|.||.:||||||||:.|||:|||.|||..|.|.:.|
  Rat   591 TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDW 655

  Fly   550 DLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFV 614
            ||..::..||..|||:.|:  :....|::.::...||...| ..|....:.|.|.:..:|.:...
  Rat   656 DLIDWEEEEEEIRPQFEAK--YSKKERMNPISGKPEPYQAF-TDKCSRLIVSASGIFFMICVVIA 717

  Fly   615 ALLAVVVYR---MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELE 676
            |:..:|:||   :|..||.|..   :..:::.|..|.:|..:|.|::.:||.:|..:|..||.||
  Rat   718 AVFGIVIYRVVTVSTFAAFKWA---LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLE 779

  Fly   677 MWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTE 740
            ..||::::::|.|||::|.||||..:|.||||||.|:|.||||.|.:|.: :|.|||...|||.:
  Rat   780 QPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLID 844

  Fly   741 LCIQLAIIMVGKQAFNTILEVYLPM---FW-RKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKL 801
            ||:|:.||||.||.:|..:|:..|:   :| |:.:..:.|..|         |....:|.:|:.|
  Rat   845 LCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGTER---------KINFPQWEKDYNL 900

  Fly   802 LDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRD 866
            ....|.|||.|||||:||:||.|||||||||||..||||||:|:||||.|.:|..:||::.|.:|
  Rat   901 QPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKD 965

  Fly   867 IGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK--------QGTLDGYLNFTLSEFK 923
            ||:||.||:.||.||||||.|:||.|||.||||||.:....        |..:.||:|.:||.|:
  Rat   966 IGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFR 1030

  Fly   924 VIDSPTLYSLAGDLSN-----ITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVA 983
            :.|.........|.|.     :..|||.|:|.||.|...|..:..|:.:||.||.|::|||:.|.
  Rat  1031 ISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVF 1095

  Fly   984 LVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSS 1033
            .:..|:.:.|||:..:|||::|||.|:..|::.:.|..|.:.||.:|..:
  Rat  1096 CIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKN 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	85/258 (33%)
		Anoctamin	431..1007	CDD:461349	259/597 (43%)
Ano4	XP_017450215.2	Anoct_dimer	310..535	CDD:465044	85/258 (33%)
		Anoctamin	538..1119	CDD:461349	259/597 (43%)