Protein Alignment subdued and Ano5

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_006540885.4
• Gene: Ano5 / 233246
• MGIID: 3576659
• Length: 988
• Species: Mus musculus
• Alignment Length: 1084
• Identity: 389/1084 - (35%)
• Similarity: 586/1084 - (54%)
• Gaps: 167/1084 - (15%)

  Fly    19 PPFSKDESFQLLERSPHNPAISPTTTVPLEPPFTTPLAPFDMELMKRHNLHERLTGKESFWRGRD 83
            ||.|::....|...|...|.:||.:.|||         ...|.|..:.:  :.|..:.|.|
Mouse     3 PPGSQEFRSSLAPPSSQAPGLSPVSPVPL---------VLQMPLESQQS--DSLKNESSSW---- 52

  Fly    84 TSQRFLDQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAPLL 148
                 :.:.:|...|:::       ||            |..|::: :|.:....|..|..|.|
Mouse    53 -----IAEAELKTRRQTI-------RF------------SLRPKSS-RRLSQRSFNAFNELAKL- 91

  Fly   149 PMTDPDFVK-------------------GNVGGVYDDRECS--CPREF---YQRGE-INTSLFFE 188
              .|||.::                   .|:|    .:|.|  .|.:.   :||.| ...|:||.
Mouse    92 --GDPDLLEMVEQEGLTAKEIDYAFQQNENLG----SKETSFLIPEDLQSPFQRSEHSKDSVFFR 150

  Fly   189 DCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVE-----SSQKDQIWFVKIHAPLE 248
            |.:|.|||||:|..:..:..||: .|:||.||.||...||::|     :|:..:.:|||||||.|
Mouse   151 DGIRQIDFVLSYVEDLKKDGELK-AERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWE 214

  Fly   249 VLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQF 313
            ||..|||:|.::||:|.|                 .....|.|.:|.:..:.| :.||:|
Mouse   215 VLVTYAEVLGIKMPIKLS-----------------DIPRPKYPPLSYMLGAVK-LPSSVK----- 256

  Fly   314 FLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDC-FFTTAVRSRIVEFILDRQRFPAKNQHD 377
                       :|...: |||.:||.::.||.|..:. ||.::.|:|||.:||.|..|..: :..
Mouse   257 -----------YPTPEY-FTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPFGVE-EGK 308

  Fly   378 MAFGIERLIAEGVYSAAYPLHDGEI-----TETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGV 437
            ...|||||:....|.:|||||||:.     |.....|..|.|:||....:|:.||...|:.|||.
Mouse   309 KKIGIERLLNSNTYLSAYPLHDGQYWKPSKTTRPNERYNLCKNWARFSYFYKEQPFHLIRNYFGE 373

  Fly   438 KIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSG-NTNITMCPLCD-WCNFW 500
            |||:||.:|||||.|||.|::||:.||:|...|::|.....:||... ...:.|||||| .|::|
Mouse   374 KIGIYFVFLGYYTEMLLFAALVGLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYW 438

  Fly   501 DLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEE--HPRP 563
            .|..||.::|.::|.||.||||||:||..|.|||||.||:..|.:.:.|||..|:..::  ..||
Mouse   439 RLNTTCLHSKFSHLFDNESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRP 503

  Fly   564 QYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLA 628
            ::.|..:|   .:::.||...||.:|... ::|....|.:.|...:||...:::::::||:|:.|
Mouse   504 EFEAMCKH---KKMNPVTKEMEPHMPLCH-RIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFA 564

  Fly   629 ALKVGASPMTTSSAI---------VLATA-SAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQ 683
            ..   ||.|.:.:.:         .|||| |.:.:|..::.|||:.|..::.::|::|:.||..:
Mouse   565 TF---ASFMESEATLQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQE 626

  Fly   684 FDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAI 747
            ::.|||||::|.||||||:|.||:|||||||||:||.|..:|: :|.|||...|||.||..||.|
Mouse   627 YESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQLTI 691

  Fly   748 IMVGKQAFNTILEVYLPM---FWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGL 809
            ||:|||.|..|.|.:.|:   :||:..| :....:|::           ||.:|..|..:|.|||
Mouse   692 IMIGKQIFGNIHEAFQPLIFNWWRRRRA-RTHSEKLYS-----------RWEQDHDLQVYGHRGL 744

  Fly   810 FPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRIL 874
            |.||||.|:|:||.|:|||:|||||.|||:|||:.:|:||.||.|.::|||:.:...||||..||
Mouse   745 FYEYLETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDIL 809

  Fly   875 DCIGKLSVITNGFIIAFTSDMIPRLV--YRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDL 937
            ..:..:||.||.||::||||:|||||  |.:..|....|.||:|.:||.|.:.|.|. :::..:.
Mouse   810 FGMAIVSVATNAFIVSFTSDIIPRLVYFYAYSTNSTEPLSGYVNNSLSVFLIADFPN-HTVPMEK 873

  Fly   938 SNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRD 1002
            .:..||||.|:|.||...:||:.:..|:.:||.::.|::|.|:.|.|...|:.|.|||:..::.:
Mouse   874 KDFVTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFLLAWLIPDVPKDVVE 938

  Fly  1003 QIRREVYVTNEIIIDQEAHRAR----FERAKRSSSVLQTPVDQD 1042
            :|:||..:|.:||.|.|.::.:    .|......:||   ||:|
Mouse   939 KIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVL---VDED 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	88/252 (35%)
		Anoctamin	431..1007	CDD:461349	248/595 (42%)
Ano5	XP_006540885.4	Anoct_dimer	148..363	CDD:465044	87/251 (35%)
		Anoctamin	367..943	CDD:461349	248/595 (42%)